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Author(s):  
Mahmoud Abbas El-Dabah ◽  
Ragab Abdelaziz El-Sehiemy ◽  
Mohamed Ahmed Ebrahim ◽  
Zuhair Alaas ◽  
Mohamed Mostafa Ramadan

This paper proposes the application of a novel metaphor-free population optimization based on the mathematics of the Runge Kutta method (RUN) for parameter extraction of a double-diode model of the unknown solar cell and photovoltaic (PV) module parameters. The RUN optimizer is employed to determine the seven unknown parameters of the two-diode model. Fitting the experimental data is the main objective of the extracted unknown parameters to develop a generic PV model. Consequently, the root means squared error (RMSE) between the measured and estimated data is considered as the primary objective function. The suggested objective function achieves the closeness degree between the estimated and experimental data. For getting the generic model, applications of the proposed RUN are carried out on two different commercial PV cells. To assess the proposed algorithm, a comprehensive comparison study is employed and compared with several well-matured optimization algorithms reported in the literature. Numerical simulations prove the high precision and fast response of the proposed RUN algorithm for solving multiple PV models. Added to that, the RUN can be considered as a good alternative optimization method for solving power systems optimization problems.


Author(s):  
Jéssica L. O. Brasileiro ◽  
Rossana M. F. de Figueirêdo ◽  
Alexandre J. de M. Queiroz ◽  
Regilane M. Feitosa

ABSTRACT Fruit pulps undergo temperature variations during processing, leading to viscosity changes. This study aimed to analyse the rheological behaviour of macaíba pulp at different temperatures (10 to 50 ºC, with 5 ºC increments) and speeds (2.5 to 200 rpm, totalling 17 speeds). Experimental measurements were performed in a Brookfield viscometer, fitting the Ostwald-de-Waele, Mizrahi-Berk, Herschel-Bulkley, and Casson models to the experimental data of shear stress as a function of shear rate. Among the models used, the Mizrahi-Berk model (R² > 0.9656 and average percentage deviation - P ≤ 4.1%) was found to best fit the rheogram data. Macaíba pulp exhibited a non-newtonian behaviour and was characterised as pseudoplastic. It showed fluid behaviour indexes below unity under the studied conditions, with decreases in apparent viscosity as temperature and shear rate increased. Such behaviour could be described by the Arrhenius equation. The Mizrahi-Berk and Falguera-Ibarz models (R² > 0.99 and P ≤ 10%) best fitted the data and were used to represent the viscosity behaviour of macaíba pulp. The activation energy values of macaíba pulp ranged between 17.53 and 25.37 kJ mol-1, showing a rheological behaviour like other fruit pulps.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Ming Cai ◽  
Limin Gao ◽  
Haoxue Li ◽  
Yangbo Ou

Abstract To obtain reliable and accurate experimental data in cascade testing, the influencing factors and the improving method of the flow quality of a highly-loaded compressor cascade under high incidence were investigated through a series of numerical simulations and experiments. The numerical method was validated by experimental data and agreed well at both incidence angles of 0° and 6°. Under the original upper end wall, both experimental and numerical results indicated an unsatisfactory flow quality of the cascade with an obvious nonuniformity of inlet Mach number, and the incidence of the central blade is 3.6° larger than the theoretical value. Using a small curved upper wall can reduce the severe flow separation on the upper wall and achieve a maximum improvement in flow quality under the critical installation angle, where the incidence deviation of the central blade was reduced to 2.1°. Using the combination of adjustable tailboards and a small curved upper end wall can further improve the cascade flow quality. Under the optimal angle of the tailboards, both the inflow uniformity and the outflow periodicity of the three middle blade passages the test requirements, and the incidence deviation of the central blade is reduced to 0.2°.


2022 ◽  
Vol 9 (1) ◽  
Author(s):  
Sergey Danilin ◽  
João Barbosa ◽  
Michael Farage ◽  
Zimo Zhao ◽  
Xiaobang Shang ◽  
...  

AbstractElectromagnetic filtering is essential for the coherent control, operation and readout of superconducting quantum circuits at milliKelvin temperatures. The suppression of spurious modes around transition frequencies of a few GHz is well understood and mainly achieved by on-chip and package considerations. Noise photons of higher frequencies – beyond the pair-breaking energies – cause decoherence and require spectral engineering before reaching the packaged quantum chip. The external wires that pass into the refrigerator and go down to the quantum circuit provide a direct path for these photons. This article contains quantitative analysis and experimental data for the noise photon flux through coaxial, filtered wiring. The attenuation of the coaxial cable at room temperature and the noise photon flux estimates for typical wiring configurations are provided. Compact cryogenic microwave low-pass filters with CR-110 and Esorb-230 absorptive dielectric fillings are presented along with experimental data at room and cryogenic temperatures up to 70 GHz. Filter cut-off frequencies between 1 to 10 GHz are set by the filter length, and the roll-off is material dependent. The relative dielectric permittivity and magnetic permeability for the Esorb-230 material in the pair-breaking frequency range of 75 to 110 GHz are measured, and the filter properties in this frequency range are calculated. The estimated dramatic suppression of the noise photon flux due to the filter proves its usefulness for experiments with superconducting quantum systems.


2022 ◽  
Author(s):  
Eitan Margulis ◽  
Yuli Slavutsky ◽  
Tatjana Lang ◽  
Mike Behrens ◽  
Yuval Benjamini ◽  
...  

Bitterness is an aversive cue elicited by thousands of chemically diverse compounds. Bitter taste may prevent consumption of foods and jeopardize drug compliance. The G protein-coupled receptors for bitter taste, TAS2Rs, have species-dependent number of subtypes and varying expression levels in extraoral tissues. Molecular recognition by TAS2R subtypes is physiologically important, and presents a challenging case study for ligand-receptor matchmaking. Inspired by hybrid recommendation systems, we developed a new set of similarity features, and created the BitterMatch algorithm that predicts associations of ligands to receptors with ~80% precision at ~50% recall. Associations for several compounds were tested in-vitro, resulting in 80% precision and 42% recall. The encouraging performance was achieved by including receptor properties and integrating experimentally determined ligand-receptor associations with chemical ligand-to-ligand similarities. BitterMatch can predict off-targets for bitter drugs, identify novel ligands and guide flavor design. Inclusion of neighbor-informed similarities improves as experimental data mounts, and provides a generalizable framework for molecule-biotarget matching.


2022 ◽  
Vol 8 ◽  
Author(s):  
Stefania De Simone ◽  
Elena Giacani ◽  
Maria Antonella Bosco ◽  
Simona Vittorio ◽  
Michela Ferrara ◽  
...  

Background:The timing of wounds production is a significant issue in forensic pathology. Although various methods have been evaluated, obtaining an accurate dating of lesions is still a challenge. The pathologist uses many parameters to value wound age, such as histological and immunohistochemical. In recent years, there have been many studies regarding the use of miRNAs in wound-age estimation; indeed, miRNAs have multiple potential uses in forensic pathology.Scope:This review aims to verify the efficacy and feasibility of miRNAs as a tool for determining the timing of lesions.Materials and Methods:The authors conducted the systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. PubMed was used as a search engine to find articles published between January, 1st 2016 and October, 1st 2021, to evaluate the current state of the art regarding wound-age estimation.Results:A total of 256 articles were collected; after screening according to PRISMA guidelines, the systematic review included 8 articles. The studies included in this review were all Original articles evaluating the use of biomarkers for wound-age determination.Discussion and Conclusion:The literature review showed that analysis of miRNA is an innovative field of study with significant potentiality in forensic pathology. There are few studies, and almost all of them are at an early stage. The challenge is to understand how to standardize the samples' selection to obtain reliable experimental data. This observation represents a necessary prerequisite to planning further clinical trials.


2022 ◽  
Author(s):  
Rong An ◽  
Shisheng Zhang ◽  
Li-Sheng Geng ◽  
Feng-Shou 张丰收 Zhang

Abstract We apply the recently proposed RMF(BCS)* ansatz to study the charge radii of the potassium isotopic chain up to $^{52}$K. It is shown that the experimental data can be reproduced rather well, qualitatively similar to the Fayans nuclear density functional theory, but with a slightly better description of the odd-even staggerings (OES). Nonetheless, both methods fail for $^{50}$K and to a lesser extent for $^{48,52}$K. It is shown that if these nuclei are deformed with a $\beta_{20}\approx-0.2$, then one can obtain results consistent with experiments for both charge radii and spin-parities. We argue that beyond mean field studies are needed to properly describe the charge radii of these three nuclei, particularly for $^{50}$K.


2022 ◽  
Vol 4 (1) ◽  
Author(s):  
Pavel P Kuksa ◽  
Yuk Yee Leung ◽  
Prabhakaran Gangadharan ◽  
Zivadin Katanic ◽  
Lauren Kleidermacher ◽  
...  

ABSTRACT Querying massive functional genomic and annotation data collections, linking and summarizing the query results across data sources/data types are important steps in high-throughput genomic and genetic analytical workflows. However, these steps are made difficult by the heterogeneity and breadth of data sources, experimental assays, biological conditions/tissues/cell types and file formats. FILER (FunctIonaL gEnomics Repository) is a framework for querying large-scale genomics knowledge with a large, curated integrated catalog of harmonized functional genomic and annotation data coupled with a scalable genomic search and querying interface. FILER uniquely provides: (i) streamlined access to >50 000 harmonized, annotated genomic datasets across >20 integrated data sources, >1100 tissues/cell types and >20 experimental assays; (ii) a scalable genomic querying interface; and (iii) ability to analyze and annotate user’s experimental data. This rich resource spans >17 billion GRCh37/hg19 and GRCh38/hg38 genomic records. Our benchmark querying 7 × 109 hg19 FILER records shows FILER is highly scalable, with a sub-linear 32-fold increase in querying time when increasing the number of queries 1000-fold from 1000 to 1 000 000 intervals. Together, these features facilitate reproducible research and streamline integrating/querying large-scale genomic data within analyses/workflows. FILER can be deployed on cloud or local servers (https://bitbucket.org/wanglab-upenn/FILER) for integration with custom pipelines and is freely available (https://lisanwanglab.org/FILER).


ADMET & DMPK ◽  
2022 ◽  
Author(s):  
Svetlana A. Berns ◽  
Julia A. Isakova ◽  
Polina Pekhtereva

Tuberculosis is one of the critical health problems worldwide. The search for ways to improve the results of tuberculosis treatment and overcome drug resistance lies in understanding the pathogenesis of the development of the infectious process. The interferon system, particularly the role of interferon-gamma, has been identified as the main link in the immune response in tuberculosis. The clinical efficacy of interferon-gamma has been studied and evaluated in clinical trials since the end of the last century. There was obtained evidence of the clinical efficacy of interferon-gamma as part of complex therapy. Recent experimental data make it possible to consider interferon-gamma as a promising therapeutic option for the treatment of multidrug-resistant tuberculosis as part of complex therapy worthy of further studies.  


Author(s):  
Ivan P Nevirkovets ◽  
Mikhail A Belogolovskii ◽  
John B Ketterson

Abstract We have fabricated and characterized all-MoGe Josephson junctions with a very thin Al/AlOx/(Al) barrier, where the amorphous MoGe films exhibit superconducting transition temperatures up to 7 K. Due to the uniformity of the surface morphology of the MoGe films, the junctions demonstrate high uniformity of their tunneling properties. The experimental data on the temperature dependence of the subgap current agree well with theoretical calculations. The results obtained imply that Josephson tunnel junctions based on amorphous superconductors are promising candidates for use in superconducting electronics, especially in applications requiring multiple stacked junctions or the creation of a nonequilibrium quasiparticle distribution.


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