Hepatic Clearance Binding Terms of Hydrophobic Organic Chemicals in Rainbow Trout: Application of a Streamlined Sorbent-Phase Dosing Method

2020 ◽  
Vol 7 (9) ◽  
pp. 672-676
Author(s):  
Leslie J. Saunders ◽  
Gabrielle Diaz-Blanco ◽  
Yung-Shan Lee ◽  
S. Victoria Otton ◽  
Frank A. P. C. Gobas
Keyword(s):  
Rainbow Trout ◽  
Hepatic Clearance ◽  
Organic Chemicals ◽  
Hydrophobic Organic Chemicals ◽  
Sorbent Phase ◽  
Dosing Method

Factors Affecting Bioconcentration of Trace Organic Contamination in Waters

1989 ◽  
Vol 21 (2) ◽  
pp. 147-150 ◽  
Author(s):  
D. W. Hawker ◽  
D. W. Connell
Keyword(s):  
Molecular Weight ◽  
Bioconcentration Factor ◽  
Aqueous Solubility ◽  
Organic Chemicals ◽  
Organic Contamination ◽  
Hydrophobic Organic Chemicals ◽  
Factors Affecting ◽  
Water Partition Coefficient ◽  
Physicochemical Factors ◽  
Trace Organic

The influence of some important biological and physicochemical factors on the bioconcentration of hydrophobic organic chemicals is outlined. For non-ionizable, persistent compounds the bioconcentration factor can be related to a compound's octanol/water partition coefficient, aqueous solubility and molecular weight, while the lipid content of an organism also affects the bioconcentration potential of these compounds. The effect of ionization and biodegradation of organic chemicals on bioconcentration is also discussed.

QSARs for estimating intrinsic hepatic clearance of organic chemicals in humans

2016 ◽  
Vol 42 ◽  
pp. 190-197 ◽  
Author(s):  
Alessandra Pirovano ◽  
Stefan Brandmaier ◽  
Mark A.J. Huijbregts ◽  
Ad M.J. Ragas ◽  
Karin Veltman ◽  
...  
Keyword(s):  
Hepatic Clearance ◽  
Organic Chemicals

A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel ( Anguilla anguilla )

2015 ◽  
Vol 536 ◽  
pp. 279-287 ◽  
Author(s):  
Markus Brinkmann ◽  
Marko Freese ◽  
Jan-Dag Pohlmann ◽  
Ulrike Kammann ◽  
Thomas G. Preuss ◽  
...  
Keyword(s):  
Anguilla Anguilla ◽  
European Eel ◽  
Organic Chemicals ◽  
Hydrophobic Organic Chemicals ◽  
Physiologically Based
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