Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c02019 ◽

2021 ◽

Author(s):

Kai Yuan ◽

Minghui Ji ◽

Shengnan Xie ◽

Zhixia Qiu ◽

Weijiao Chen ◽

...

Keyword(s):

Acute Myeloid Leukemia ◽

Myeloid Leukemia ◽

High Potency ◽

Novel Structure ◽

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Analysis of FLT3-ITD and FLT3-Asp835 Mutations in de novo Acute Myeloid Leukemia: Evaluation of Incidence, Distribution Pattern, Correlation with Cytogenetics and Characterization of Internal Tandem Duplication from Indian Population

Cancer Investigation ◽

10.1080/07357900903095649 ◽

2009 ◽

pp. 1-1

Author(s):

Firoz Ahmad ◽

Swarna Mandava ◽

Bibhu Ranjan Das

Keyword(s):

Acute Myeloid Leukemia ◽

Distribution Pattern ◽

Myeloid Leukemia ◽

Indian Population ◽

Tandem Duplication ◽

De Novo ◽

Internal Tandem Duplication ◽

Pattern Correlation ◽

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Review for "Expanded clinical‐grade membrane‐bound IL‐21/4‐1BBL NK cell products exhibit activity against acute myeloid leukemia in vivo"

10.1002/eji.201948375/v1/review1 ◽

2019 ◽

Author(s):

Nicolas Dulphy

Keyword(s):

Acute Myeloid Leukemia ◽

Myeloid Leukemia ◽

Nk Cell ◽

Clinical Grade ◽

Membrane Bound ◽

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Immunotoxin Therapy for Acute Myeloid Leukemia

PsycEXTRA Dataset ◽

10.1037/e311892005-005 ◽

2005 ◽

Author(s):

Keyword(s):

Acute Myeloid Leukemia ◽

Myeloid Leukemia ◽

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Decision letter for "Over expression of brain and acute leukemia, cytoplasmic and ETS-related gene is associated with poor outcome in acute myeloid leukemia"

10.1002/hon.2800/v3/decision1 ◽

2020 ◽

Keyword(s):

Acute Myeloid Leukemia ◽

Acute Leukemia ◽

Myeloid Leukemia ◽

Related Gene ◽

Over Expression ◽

Poor Outcome ◽

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Author response for "Over expression of brain and acute leukemia, cytoplasmic and ETS-related gene is associated with poor outcome in acute myeloid leukemia"

10.1002/hon.2800/v2/response1 ◽

2020 ◽

Author(s):

Hasan, Syed Khizer ◽

Patkar, Nikhil V. ◽

Rajamanickam, Deepan ◽

Gokarn, Anant ◽

Lucena-Araujo, Antonio R. ◽

...

Keyword(s):

Acute Myeloid Leukemia ◽

Acute Leukemia ◽

Myeloid Leukemia ◽

Author Response ◽

Related Gene ◽

Over Expression ◽

Poor Outcome ◽

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Review for "How to select older patients with acute myeloid leukemia fit for intensive treatment?"

10.1002/hon.2798/v1/review1 ◽

2020 ◽

Author(s):

Takaaki Konuma

Keyword(s):

Acute Myeloid Leukemia ◽

Older Patients ◽

Myeloid Leukemia ◽

Intensive Treatment ◽

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Decision letter for "How to select older patients with acute myeloid leukemia fit for intensive treatment?"

10.1002/hon.2798/v1/decision1 ◽

2020 ◽

Keyword(s):

Acute Myeloid Leukemia ◽

Older Patients ◽

Myeloid Leukemia ◽

Intensive Treatment ◽

Download Full-text

Review for "LncRNA LINP1 regulates acute myeloid leukemia progression via HNF4α/AMPK/WNT5A signaling pathway"

10.1002/hon.2651/v2/review1 ◽

2019 ◽

Keyword(s):

Acute Myeloid Leukemia ◽

Signaling Pathway ◽

Myeloid Leukemia ◽

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Decision letter for "LncRNA LINP1 regulates acute myeloid leukemia progression via HNF4α/AMPK/WNT5A signaling pathway"

10.1002/hon.2651/v2/decision1 ◽

2019 ◽

Keyword(s):

Acute Myeloid Leukemia ◽

Signaling Pathway ◽

Myeloid Leukemia ◽

Download Full-text

Decision letter for "LncRNA LINP1 regulates acute myeloid leukemia progression via HNF4α/AMPK/WNT5A signaling pathway"

10.1002/hon.2651/v1/decision1 ◽

2019 ◽

Keyword(s):

Acute Myeloid Leukemia ◽

Signaling Pathway ◽

Myeloid Leukemia ◽

Download Full-text