Palladium-Catalyzed Asymmetric (2+3) Annulation of p-Quinone Methides with Trimethylenemethanes: Enantioselective Synthesis of Functionalized Chiral Spirocyclopentyl p-Dienones

2020 ◽  
Vol 22 (11) ◽  
pp. 4171-4175 ◽  
Author(s):  
Zhi-Long Jia ◽  
Xian-Tao An ◽  
Yu-Hua Deng ◽  
Hui-Bin Wang ◽  
Kang-Ji Gan ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Quinone Methides ◽  
Palladium Catalyzed

Novel Chiral Ligands for Palladium-catalyzed Asymmetric Allylic Alkylation/ Asymmetric Tsuji-Trost Reaction: A Review

2019 ◽  
Vol 23 (11) ◽  
pp. 1168-1213 ◽  
Author(s):  
Samar Noreen ◽  
Ameer Fawad Zahoor ◽  
Sajjad Ahmad ◽  
Irum Shahzadi ◽  
Ali Irfan ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Enantioselective Synthesis ◽  
Chiral Ligands ◽  
Allylic Alkylation ◽  
Research Groups ◽  
Asymmetric Allylic Alkylation ◽  
Catalytic Potential ◽  
Long Time ◽  
Palladium Catalyzed ◽  
Alkylation Reactions

Background: Asymmetric catalysis holds a prestigious role in organic syntheses since a long time and chiral inductors such as ligands have been used to achieve the utmost desired results at this pitch. The asymmetric version of Tsuji-Trost allylation has played a crucial role in enantioselective synthesis. Various chiral ligands have been known for Pdcatalyzed Asymmetric Allylic Alkylation (AAA) reactions and exhibited excellent catalytic potential. The use of chiral ligands as asymmetric inductors has widened the scope of Tsuji-Trost allylic alkylation reactions. Conclusion: Therefore, in this review article, a variety of chiral inductors or ligands have been focused for palladium catalyzed asymmetric allylic alkylation (Tsuji-Trost allylation) and in this regard, recently reported literature (2013-2017) has been described. The use of ligands causes the induction of enantiodiscrimination to the allylated products, therefore, the syntheses of various kinds of ligands have been targeted by many research groups to employ in Pd-catalyzed AAA reactions.

Palladium-Catalyzed Generation of ortho-Quinone Methides. A Three-Component Synthesis of L-Shaped Dimeric Steroidal Scaffolds

2021 ◽  
Vol 86 (5) ◽  
pp. 4112-4120
Author(s):  
Martha C. Mayorquín-Torres ◽  
Armando Navarro-Huerta ◽  
Mauricio Maldonado-Domínguez ◽  
Marcos Flores-Álamo ◽  
Braulio Rodríguez-Molina ◽  
...  
Keyword(s):  
Quinone Methides ◽  
Palladium Catalyzed

scholarly journals Catalytic enantioselective synthesis of macrodiolides and their application in chiral recognition

2021 ◽  
Author(s):  
Wanlong Xiao ◽  
Yuhao Mo ◽  
Jing Guo ◽  
Zhishan Su ◽  
Shunxi Dong ◽  
...  
Keyword(s):  
Chiral Recognition ◽  
Enantioselective Synthesis ◽  
Quinone Methides ◽  
New Type

A new type of C2-symmetric chiral macrodiolides are readily obtained via chiral N,Nʹ-dioxide-scandium(III) complex-promoted asymmetric tandem Friedel-Crafts alkylation/intermolecular macrolactonization of ortho-quinone methides with C3-substituted indoles. This protocol provides an array...

Palladium-Catalyzed Enantioselective Synthesis of Cyclic Sulfamidates and Application to a Synthesis of Verubecestat

2018 ◽  
Vol 20 (5) ◽  
pp. 1265-1268 ◽  
Author(s):  
Wenyong Chen ◽  
Dongfang Meng ◽  
Blaise N’Zemba ◽  
William J. Morris
Keyword(s):  
Enantioselective Synthesis ◽  
Palladium Catalyzed
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