Nanofibrous Nerve Conduits with Nerve Growth Factors and Bone Marrow Stromal Cells Pre-Cultured in Bioreactors for Peripheral Nerve Regeneration

2020 ◽  
Vol 12 (14) ◽  
pp. 16168-16177 ◽  
Author(s):  
Gan Zhou ◽  
Wei Chang ◽  
Xiaqing Zhou ◽  
Yifan Chen ◽  
Futao Dai ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Growth Factors ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Peripheral Nerve Regeneration ◽  
Marrow Stromal Cells ◽  
Nerve Conduits ◽  
Nerve Growth Factors

Peripheral nerve regeneration by bone marrow stromal cells

2002 ◽  
Vol 24 (7) ◽  
pp. 634-638 ◽  
Author(s):  
Pedro Cuevas ◽  
Fernando Carceller ◽  
Manuel Dujovny ◽  
Ignacio Garcia-Gómez ◽  
Begona A Cuevas ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Peripheral Nerve Regeneration ◽  
Marrow Stromal Cells

scholarly journals Peripheral Nerve Regeneration Using a Bio 3D ConduitFfrom Undifferentiated Bone Marrow Stromal Cells

2018 ◽  
Vol 43 (9) ◽  
pp. S33-S34
Author(s):  
Hirofumi Yurie ◽  
Ryosuke Ikeguchi ◽  
Soichi Ohta ◽  
Hiroki Oda ◽  
Hisataka Takeuchi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Peripheral Nerve Regeneration ◽  
Marrow Stromal Cells

scholarly journals Bio 3D Conduits Derived from Bone Marrow Stromal Cells Promote Peripheral Nerve Regeneration

2020 ◽  
Vol 29 ◽  
pp. 096368972095155
Author(s):  
Hirofumi Yurie ◽  
Ryosuke Ikeguchi ◽  
Tomoki Aoyama ◽  
Mai Tanaka ◽  
Hiroki Oda ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Peripheral Nerve Regeneration ◽  
Cell Trafficking ◽  
Nerve Conduits ◽  
S 100 ◽  
Nerve Model

We previously reported that a nerve conduit created from fibroblasts promotes nerve regeneration in a rat sciatic nerve model. This study aims to determine whether a nerve conduit created from bone marrow stromal cells (BMSCs) can promote nerve regeneration. Primary BMSCs were isolated from femur bone marrow of two Lewis rats, and cells at passages 4–7 were used. We created seven Bio 3D nerve conduits from BMSCs using a Bio-3D Printer. The conduits were transplanted to other Lewis rats to bridge 5-mm right sciatic nerve gaps (Bio 3D group, n = 7). We created two control groups: a silicone group (S group, n = 5) in which the same nerve gap was bridged with a silicone tube, and a silicone cell group (SC group, n = 5) in which the gap was bridged with a BMSC injection. Twelve weeks after transplantation, nerve regeneration was evaluated functionally and morphologically. In addition, PKH26-labeled BMSCs were used to fabricate a Bio 3D conduit that was transplanted for cell trafficking analysis. Electrophysiological study, kinematic analysis, wet muscle weight, and morphological parameters showed significantly better nerve regeneration in the Bio 3D group than in the S group or SC group. In immunohistochemical studies, sections from the Bio 3D group contained abundant S-100-positive cells. In cell trafficking analysis, PKH26-positive cells stained positive for the Schwann cell markers S-100, p75NTR, and GFAP. Bio 3D nerve conduits created from BMSCs can promote peripheral nerve regeneration in a rat sciatic nerve model through BMSC differentiation into Schwann-like cells.

Tissue-engineered peripheral nerve grafting by differentiated bone marrow stromal cells

Neuroscience ◽  
2006 ◽  
Vol 140 (1) ◽  
pp. 101-110 ◽  
Author(s):  
S.-Y. Hou ◽  
H.-Y. Zhang ◽  
D.-P. Quan ◽  
X.-L. Liu ◽  
J.-K. Zhu
Keyword(s):  
Bone Marrow ◽  
Peripheral Nerve ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Nerve Grafting ◽  
Peripheral Nerve Grafting

Bone marrow stromal cells and resorbable collagen guidance tubes enhance sciatic nerve regeneration in mice

2006 ◽  
Vol 198 (2) ◽  
pp. 457-468 ◽  
Author(s):  
Fátima Rosalina Pereira Lopes ◽  
Lenira Camargo de Moura Campos ◽  
José Dias Corrêa ◽  
Alex Balduino ◽  
Silvano Lora ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Sciatic Nerve Regeneration
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