Tissue-engineered peripheral nerve grafting by differentiated bone marrow stromal cells

Neuroscience ◽  
2006 ◽  
Vol 140 (1) ◽  
pp. 101-110 ◽  
Author(s):  
S.-Y. Hou ◽  
H.-Y. Zhang ◽  
D.-P. Quan ◽  
X.-L. Liu ◽  
J.-K. Zhu
2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Vinnitsa Buzoianu-Anguiano ◽  
Sandra Orozco-Suárez ◽  
Elisa García-Vences ◽  
Sara Caballero-Chacón ◽  
Gabriel Guizar-Sahagún ◽  
...  

Functional recovery following spinal cord injury (SCI) is limited by poor axonal and cellular regeneration as well as the failure to replace damaged myelin. Employed separately, both the transplantation of the predegenerated peripheral nerve (PPN) and the transplantation of bone marrow stromal cells (BMSCs) have been shown to promote the regrowth and remyelination of the damaged central axons in SCI models of hemisection, transection, and contusion injury. With the aim to test the effects of the combined transplantation of PPN and BMSC on regrowth, remyelination, and locomotor function in an adult rat model of spinal cord (SC) transection, 39 Fischer 344 rats underwent SC transection at T9 level. Four weeks later they were randomly assigned to traumatic spinal cord injury (TSCI) without treatment, TSCI + Fibrin Glue (FG), TSCI + FG + PPN, and TSCI + FG + PPN + BMSCs. Eight weeks after, transplantation was carried out on immunofluorescence and electron microscope studies. The results showed greater axonal regrowth and remyelination in experimental groups TSCI + FG + PPN and TSCI + FG + PPN + BMSCs analyzed with GAP-43, neuritin, and myelin basic protein. It is concluded that the combined treatment of PPN and BMSCs is a favorable strategy for axonal regrowth and remyelination in a chronic SC transection model.


2007 ◽  
Vol 204 (1) ◽  
pp. 443-453 ◽  
Author(s):  
Chun-Jung Chen ◽  
Yen-Chuan Ou ◽  
Su-Lan Liao ◽  
Wen-Ying Chen ◽  
Shih-Yun Chen ◽  
...  

2005 ◽  
Vol 21 (08) ◽  
pp. 565-572 ◽  
Author(s):  
Peixun Zhang ◽  
Xiangjun He ◽  
Fuqiang Zhao ◽  
Dianying Zhang ◽  
Zhongguo Fu ◽  
...  

2011 ◽  
Vol 67 (1) ◽  
pp. 73-84 ◽  
Author(s):  
Maria Siemionow ◽  
William Duggan ◽  
Grzegorz Brzezicki ◽  
Aleksandra Klimczak ◽  
Christopher Grykien ◽  
...  

2002 ◽  
Vol 24 (7) ◽  
pp. 634-638 ◽  
Author(s):  
Pedro Cuevas ◽  
Fernando Carceller ◽  
Manuel Dujovny ◽  
Ignacio Garcia-Gómez ◽  
Begona A Cuevas ◽  
...  

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