Tissue-engineered peripheral nerve grafting by differentiated bone marrow stromal cells

Neuroscience ◽  
2006 ◽  
Vol 140 (1) ◽  
pp. 101-110 ◽  
Author(s):  
S.-Y. Hou ◽  
H.-Y. Zhang ◽  
D.-P. Quan ◽  
X.-L. Liu ◽  
J.-K. Zhu
Keyword(s):  
Bone Marrow ◽  
Peripheral Nerve ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Nerve Grafting ◽  
Peripheral Nerve Grafting

scholarly journals The Morphofunctional Effect of the Transplantation of Bone Marrow Stromal Cells and Predegenerated Peripheral Nerve in Chronic Paraplegic Rat Model via Spinal Cord Transection

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Vinnitsa Buzoianu-Anguiano ◽  
Sandra Orozco-Suárez ◽  
Elisa García-Vences ◽  
Sara Caballero-Chacón ◽  
Gabriel Guizar-Sahagún ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Peripheral Nerve ◽  
Rat Model ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Axonal Regrowth ◽  
Cord Injury

Functional recovery following spinal cord injury (SCI) is limited by poor axonal and cellular regeneration as well as the failure to replace damaged myelin. Employed separately, both the transplantation of the predegenerated peripheral nerve (PPN) and the transplantation of bone marrow stromal cells (BMSCs) have been shown to promote the regrowth and remyelination of the damaged central axons in SCI models of hemisection, transection, and contusion injury. With the aim to test the effects of the combined transplantation of PPN and BMSC on regrowth, remyelination, and locomotor function in an adult rat model of spinal cord (SC) transection, 39 Fischer 344 rats underwent SC transection at T9 level. Four weeks later they were randomly assigned to traumatic spinal cord injury (TSCI) without treatment, TSCI + Fibrin Glue (FG), TSCI + FG + PPN, and TSCI + FG + PPN + BMSCs. Eight weeks after, transplantation was carried out on immunofluorescence and electron microscope studies. The results showed greater axonal regrowth and remyelination in experimental groups TSCI + FG + PPN and TSCI + FG + PPN + BMSCs analyzed with GAP-43, neuritin, and myelin basic protein. It is concluded that the combined treatment of PPN and BMSCs is a favorable strategy for axonal regrowth and remyelination in a chronic SC transection model.

Transplantation of bone marrow stromal cells for peripheral nerve repair

2007 ◽  
Vol 204 (1) ◽  
pp. 443-453 ◽  
Author(s):  
Chun-Jung Chen ◽  
Yen-Chuan Ou ◽  
Su-Lan Liao ◽  
Wen-Ying Chen ◽  
Shih-Yun Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Nerve ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Nerve Repair ◽  
Marrow Stromal Cells ◽  
Peripheral Nerve Repair

Bridging Small-Gap Peripheral Nerve Defects Using Biodegradable Chitin Conduits with Cultured Schwann and Bone Marrow Stromal Cells in Rats

2005 ◽  
Vol 21 (08) ◽  
pp. 565-572 ◽  
Author(s):  
Peixun Zhang ◽  
Xiangjun He ◽  
Fuqiang Zhao ◽  
Dianying Zhang ◽  
Zhongguo Fu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Nerve ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells

Peripheral Nerve Defect Repair With Epineural Tubes Supported With Bone Marrow Stromal Cells

2011 ◽  
Vol 67 (1) ◽  
pp. 73-84 ◽  
Author(s):  
Maria Siemionow ◽  
William Duggan ◽  
Grzegorz Brzezicki ◽  
Aleksandra Klimczak ◽  
Christopher Grykien ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Nerve ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Defect Repair

Peripheral nerve regeneration by bone marrow stromal cells

2002 ◽  
Vol 24 (7) ◽  
pp. 634-638 ◽  
Author(s):  
Pedro Cuevas ◽  
Fernando Carceller ◽  
Manuel Dujovny ◽  
Ignacio Garcia-Gómez ◽  
Begona A Cuevas ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Peripheral Nerve Regeneration ◽  
Marrow Stromal Cells
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