One-Pot Chemoenzymatic Conversion of Alkynes to Chiral Amines

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We present a concurrent chemo/biocatalytic one pot reaction cascade by combining a metal (Pd/Cu) assisted Liebeskind–Srogl coupling with an enantioselective enzymatic reduction for the production of chiral amines and alcohols.


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Vijay N. Wakchaure ◽  
Rashmi R. Mohanty ◽  
Ahson J. Shaikh ◽  
Thomas C. Nugent
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