In Silico Identification and Experimental Validation of Peptide-Based Inhibitors Targeting Clostridium difficile Toxin A

ACS Chemical Biology ◽

10.1021/acschembio.1c00743 ◽

2021 ◽

Author(s):

Xingqing Xiao ◽

Sudeep Sarma ◽

Stefano Menegatti ◽

Nathan Crook ◽

Scott T. Magness ◽

...

Keyword(s):

Clostridium Difficile ◽

In Silico ◽

Experimental Validation ◽

Toxin A ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A ◽

In Silico Identification

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Mitochondrial generation of reactive oxygen species (ROS) is necessary for IL-8 release from colonocytes exposed to Clostridium difficile toxin A

Gastroenterology ◽

10.1016/s0016-5085(01)81607-3 ◽

2001 ◽

Vol 120 (5) ◽

pp. A323-A323

Author(s):

D HE ◽

C POTHOULAKIS ◽

S HAGEN ◽

J LAMONT

Keyword(s):

Reactive Oxygen Species ◽

Clostridium Difficile ◽

Reactive Oxygen ◽

Oxygen Species ◽

Toxin A ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A

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Faculty Opinions recommendation of Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022843.262681 ◽

2004 ◽

Author(s):

Klaus Aktories

Keyword(s):

Clostridium Difficile ◽

Gene Product ◽

Early Gene ◽

Toxin A ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A

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Faculty Opinions recommendation of Carbohydrate recognition by Clostridium difficile toxin A.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1032155.373806 ◽

2006 ◽

Author(s):

Nicola Pohl

Keyword(s):

Clostridium Difficile ◽

Carbohydrate Recognition ◽

Toxin A ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A

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Genetic Engineering of Clostridium Difficile Toxin a Vaccine

10.21236/ada230411 ◽

1990 ◽

Author(s):

Lycurgus L. Muldrow ◽

Joe Johnson

Keyword(s):

Clostridium Difficile ◽

Genetic Engineering ◽

Toxin A ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A

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Analysis of latex agglutination test for Clostridium difficile toxin A (D-1) and differentiation between C difficile toxins A and B and latex reactive protein.

Journal of Clinical Pathology ◽

10.1136/jcp.40.5.573 ◽

1987 ◽

Vol 40 (5) ◽

pp. 573-580 ◽

Cited By ~ 16

Author(s):

S P Borriello ◽

F E Barclay ◽

P J Reed ◽

A R Welch ◽

J D Brown ◽

...

Keyword(s):

Clostridium Difficile ◽

Latex Agglutination ◽

Agglutination Test ◽

Latex Agglutination Test ◽

Toxin A ◽

Reactive Protein ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A

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Enhancement of cell-mediated cytotoxicity by Clostridium difficile toxin A: An in vitro study

Toxicon ◽

10.1016/0041-0101(91)90016-k ◽

1991 ◽

Vol 29 (4-5) ◽

pp. 417-428 ◽

Cited By ~ 9

Author(s):

W. Malorni ◽

S. Paradisi ◽

M.L. Dupuis ◽

C. Fiorentini ◽

C. Ramoni

Keyword(s):

Clostridium Difficile ◽

In Vitro Study ◽

Vitro Study ◽

Toxin A ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A

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Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats

Neuroscience Letters ◽

10.1016/s0304-3940(00)01451-8 ◽

2000 ◽

Vol 292 (2) ◽

pp. 95-98 ◽

Cited By ~ 11

Author(s):

Christopher R Mantyh ◽

Douglas C McVey ◽

Steven R Vigna

Keyword(s):

Clostridium Difficile ◽

Toxin A ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A

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Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis

PLoS Pathogens ◽

10.1371/journal.ppat.1006070 ◽

2016 ◽

Vol 12 (12) ◽

pp. e1006070 ◽

Cited By ~ 17

Author(s):

Ramyavardhanee Chandrasekaran ◽

Anne K. Kenworthy ◽

D. Borden Lacy

Keyword(s):

Clostridium Difficile ◽

Toxin A ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A

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Extrinsic denervation inhibits clostridium difficile toxin A-induced enteritis

Gastroenterology ◽

10.1016/s0016-5085(00)85666-8 ◽

2000 ◽

Vol 118 (4) ◽

pp. A882

Author(s):

Christopher R. Mantyh ◽

Douglas C. McVey ◽

Steven R. Vigna

Keyword(s):

Clostridium Difficile ◽

Extrinsic Denervation ◽

Toxin A ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A

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Inhibition of Clostridium difficile Toxin A?Induced Colitis in Rats by APAZA

Digestive Diseases and Sciences ◽

10.1007/s10620-005-2476-1 ◽

2005 ◽

Vol 50 (3) ◽

pp. 565-573 ◽

Cited By ~ 6

Author(s):

Douglas C. Mcvey ◽

Rodger A. Liddle ◽

Jennifer y ◽

Nnochiri Ekwuribe ◽

Steven R. Vigna

Keyword(s):

Clostridium Difficile ◽

Toxin A ◽

Clostridium Difficile Toxin ◽

Clostridium Difficile Toxin A

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