Paired-Cysteine Scanning Reveals Conformationally Sensitive Proximity between the TM4b-4c Loop and TM8 of the Glutamate Transporter EAAT1

Shaogang Qu; Wenlong Zhang; Suifen He; Xiuping Zhang

doi:10.1021/acschemneuro.9b00048

Paired-Cysteine Scanning Reveals Conformationally Sensitive Proximity between the TM4b-4c Loop and TM8 of the Glutamate Transporter EAAT1

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.9b00048 ◽

2019 ◽

Vol 10 (5) ◽

pp. 2541-2550 ◽

Cited By ~ 1

Author(s):

Shaogang Qu ◽

Wenlong Zhang ◽

Suifen He ◽

Xiuping Zhang

Keyword(s):

Glutamate Transporter ◽

Cysteine Scanning

Download Full-text

Cysteine-scanning Mutagenesis Reveals a Highly Amphipathic, Pore-lining Membrane-spanning Helix in the Glutamate Transporter GltT

Journal of Biological Chemistry ◽

10.1074/jbc.m011064200 ◽

2001 ◽

Vol 276 (14) ◽

pp. 10775-10781 ◽

Cited By ~ 36

Author(s):

Dirk Jan Slotboom ◽

Wil N. Konings ◽

Juke S. Lolkema

Keyword(s):

Glutamate Transporter ◽

Cysteine Scanning ◽

Cysteine Scanning Mutagenesis ◽

Membrane Spanning ◽

Pore Lining

Download Full-text

Cysteine-scanning Mutagenesis Reveals a Conformationally Sensitive Reentrant Pore-Loop in the Glutamate Transporter GLT-1

Journal of Biological Chemistry ◽

10.1074/jbc.m202248200 ◽

2002 ◽

Vol 277 (29) ◽

pp. 26074-26080 ◽

Cited By ~ 52

Author(s):

Myriam Grunewald ◽

David Menaker ◽

Baruch I. Kanner

Keyword(s):

Glutamate Transporter ◽

Cysteine Scanning ◽

Cysteine Scanning Mutagenesis

Download Full-text

Cysteine Scanning of the Surroundings of an Alkali-Ion Binding Site of the Glutamate Transporter GLT-1 Reveals a Conformationally Sensitive Residue

Journal of Biological Chemistry ◽

10.1074/jbc.273.23.14231 ◽

1998 ◽

Vol 273 (23) ◽

pp. 14231-14237 ◽

Cited By ~ 59

Author(s):

Ruth Zarbiv ◽

Myriam Grunewald ◽

Michael P. Kavanaugh ◽

Baruch I. Kanner

Keyword(s):

Binding Site ◽

Glutamate Transporter ◽

Ion Binding ◽

Cysteine Scanning ◽

Alkali Ion

Download Full-text

Cysteine Scanning Mutagenesis of TM4b-4c Loop of Glutamate Transporter EAAT1 Reveals Three Conformationally Sensitive Residues

Molecular Pharmacology ◽

10.1124/mol.117.111245 ◽

2018 ◽

Vol 94 (1) ◽

pp. 713-721 ◽

Cited By ~ 4

Author(s):

Wenlong Zhang ◽

Xiuping Zhang ◽

Shaogang Qu

Keyword(s):

Glutamate Transporter ◽

Cysteine Scanning ◽

Cysteine Scanning Mutagenesis

Download Full-text

Cysteine Scanning Mutagenesis of Transmembrane Helix 3 of a Brain Glutamate Transporter Reveals Two Conformationally Sensitive Positions

Journal of Biological Chemistry ◽

10.1074/jbc.m112.403576 ◽

2012 ◽

Vol 288 (2) ◽

pp. 964-973 ◽

Cited By ~ 8

Author(s):

Nechama Silverstein ◽

Thomas J. Crisman ◽

Lucy R. Forrest ◽

Baruch I. Kanner

Keyword(s):

Transmembrane Helix ◽

Glutamate Transporter ◽

Cysteine Scanning ◽

Cysteine Scanning Mutagenesis

Download Full-text

Antisense knockdown of the glial glutamate transporter GLT-1 exacerbates hippocampal neuronal damage following traumatic injury to rat brain

European Journal of Neuroscience ◽

10.1046/j.1460-9568.2001.01367.x ◽

2001 ◽

Vol 13 (1) ◽

pp. 119-128 ◽

Cited By ~ 42

Author(s):

Vemuganti L. Raghavendra Rao ◽

Aclan Dogan ◽

Kellie K. Bowen ◽

Kathryn G. Todd ◽

Robert J. Dempsey

Keyword(s):

Rat Brain ◽

Neuronal Damage ◽

Traumatic Injury ◽

Glutamate Transporter ◽

Glial Glutamate Transporter ◽

Antisense Knockdown

Download Full-text

Faculty Opinions recommendation of Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1019587.222445 ◽

2004 ◽

Author(s):

Venkatesh Murthy

Keyword(s):

Glutamate Transporter ◽

Retrograde Signaling ◽

Inhibitory Synapses ◽

Vesicular Glutamate Transporter ◽

Layer 2

Download Full-text

Faculty Opinions recommendation of Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023260.266688 ◽

2005 ◽

Author(s):

Gerald Pier

Keyword(s):

Glutamate Transporter ◽

Beta Lactam ◽

Beta Lactam Antibiotics ◽

Transporter Expression

Download Full-text

Faculty Opinions recommendation of Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022585.258639 ◽

2004 ◽

Author(s):

Nils Brose

Keyword(s):

Glutamate Release ◽

Glutamate Transporter ◽

Quantal Content ◽

Vesicular Glutamate Transporter

Download Full-text

Faculty Opinions recommendation of Opposite movement of the external gate of a glutamate transporter homolog upon binding cotransported sodium compared with substrate.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10313956.14779167 ◽

2011 ◽

Author(s):

Gary Rudnick

Keyword(s):

Glutamate Transporter

Download Full-text