Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.1c00505 ◽

2021 ◽

Author(s):

Lan Xie ◽

Masuo Goto ◽

Xiaoyan Chen ◽

Susan L. Morris-Natschke ◽

Kuo-Hsiung Lee

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Lead Optimization ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and Biological Evaluation of 3-Chloro-4-(indol-3-yl)-2,5- pyrroledione Derivatives as Antitumor Agents

Letters in Drug Design & Discovery ◽

10.2174/1570180811310050003 ◽

2013 ◽

Vol 10 (5) ◽

pp. 382-389 ◽

Author(s):

Yuchen Lin ◽

Jing Chen

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and Biological Evaluation of Diaryl Ether Linked DC-81 Conjugates as Potential Antitumor Agents

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520613666131125122408 ◽

2013 ◽

Vol 13 (10) ◽

pp. 1590-1600 ◽

Author(s):

Ahmed Kamal ◽

A. Viswanath ◽

M. Ramaiah ◽

J. Murty ◽

Farheen Sultana ◽

...

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Diaryl Ether ◽

Synthesis And Biological Evaluation ◽

Potential Antitumor

Download Full-text

Design, synthesis, and biological evaluation of 3-(1-benzotriazole)-nor-β-lapachones as NQO1-directed antitumor agents

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104995 ◽

2021 ◽

pp. 104995

Author(s):

Li-Qiang Wu ◽

Xin Ma ◽

Zhao-Peng Liu

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

Download Full-text

Oxo-heterocyclic fused naphthalimides as antitumor agents: Synthesis and biological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2012.12.039 ◽

2013 ◽

Vol 62 ◽

pp. 130-138 ◽

Author(s):

Shaoying Tan ◽

Hong Yin ◽

Zhuo Chen ◽

Xuhong Qian ◽

Yufang Xu

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2011.10.009 ◽

2011 ◽

Vol 46 (12) ◽

pp. 5970-5977 ◽

Author(s):

Hongbin Zou ◽

Liang Zhang ◽

Jingfeng Ouyang ◽

Marc A. Giulianotti ◽

Yongping Yu

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation ◽

Potential Antitumor

Download Full-text

Synthesis and biological evaluation of a new series of benzimidazole derivatives as antimicrobial, antiquorum-sensing and antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.03.018 ◽

2017 ◽

Vol 131 ◽

pp. 255-262 ◽

Author(s):

N.S. El-Gohary ◽

M.I. Shaaban

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Benzimidazole Derivatives ◽

Synthesis And Biological Evaluation

Download Full-text

ChemInform Abstract: Antitumor Agents. Part 202. Novel 2′-Amino Chalcones: Design, Synthesis, and Biological Evaluation.

10.1002/chin.200029085 ◽

2010 ◽

Vol 31 (29) ◽

pp. no-no

Author(s):

Yi Xia ◽

Zheng-Yu Yang ◽

Peng Xia ◽

Kenneth F. Bastow ◽

Yuka Nakanishi ◽

...

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and Biological Evaluation of Novel Phenothiazine Derivatives as Potential Antitumor Agents

Polycyclic Aromatic Compounds ◽

10.1080/10406638.2021.2021254 ◽

2022 ◽

pp. 1-10

Author(s):

K. Venkatesan ◽

V. S. V. Satyanarayana ◽

A. Sivakumar

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Phenothiazine Derivatives ◽

Synthesis And Biological Evaluation ◽

Potential Antitumor

Download Full-text

Design, synthesis and biological evaluation of novel 7-amino-[1,2,4]triazolo[4,3-f]pteridinone, and 7-aminotetrazolo[1,5-f]pteridinone derivative as potent antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.12.009 ◽

2019 ◽

Vol 163 ◽

pp. 690-709 ◽

Author(s):

Yunlei Hou ◽

Liangyu Zhu ◽

Zhiwei Li ◽

Qi Shen ◽

Qiaoling Xu ◽

...

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

Download Full-text

Design, synthesis and biological evaluation of thiourea and nicotinamide-containing sorafenib analogs as antitumor agents

MedChemComm ◽

10.1039/c4md00536h ◽

2015 ◽

Vol 6 (5) ◽

pp. 867-870 ◽

Author(s):

Xiangkai Kong ◽

Zeyu Yao ◽

Zuopeng He ◽

Wenfang Xu ◽

Jianwen Yao

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

Thiourea and nicotinamide-containing sorafenib analogs with better antiproliferative and anti-angiogenic activities than sorafenib were well designed and synthesized.

Download Full-text