Titanium-Catalyzed Enantioselective Additions of Alkyl Groups to Aldehydes:  Mechanistic Studies and New Concepts in Asymmetric Catalysis

2003 ◽  
Vol 36 (10) ◽  
pp. 739-749 ◽  
Author(s):  
Patrick J. Walsh
Keyword(s):  
Asymmetric Catalysis ◽  
Mechanistic Studies ◽  
Alkyl Groups ◽  
New Concepts

Mechanistic Studies on a Facile Ring-Flipping Process in Planar Chiral Ferrocenes under Ambient and High Pressure and Its Relevance to Asymmetric Catalysis

2004 ◽  
Vol 23 (4) ◽  
pp. 906-912 ◽  
Author(s):  
Owen J. Curnow ◽  
Glen M. Fern ◽  
Michelle L. Hamilton ◽  
Achim Zahl ◽  
Rudi van Eldik
Keyword(s):  
High Pressure ◽  
Asymmetric Catalysis ◽  
Mechanistic Studies

scholarly journals Photoenzymatic Synthesis of 𝜶-Tertiary Amines By Engineered Flavin-Dependent ‘Ene’-Reductases

2021 ◽  
Author(s):  
Xin Gao ◽  
Joshua Turek-Herman ◽  
Young Joo Choi ◽  
Ryan Cohen ◽  
Todd Hyster
Keyword(s):  
Asymmetric Catalysis ◽  
Tertiary Amines ◽  
Mechanistic Studies ◽  
Common Motif ◽  
Ct Complex

𝛼-tertiary amines are a common motif in pharmaceutically important molecules but are challenging to prepare using asymmetric catalysis. Here, we demonstrate engineered flavin-dependent ‘ene’-reductases (EREDs) can catalyze radical additions into oximes to prepare this motif. Two different EREDs were evolved into competent catalysts for this transformation with high levels of stereoselectivity. Mechanistic studies indicate that the oxime contributes to the enzyme templated CT-complex formed between the substrate and cofactor. These products can be further deri-vatized to prepare a variety of motifs, highlighting the ver-satility of ERED photoenzymatic catalysis for organic syn-thesis.

scholarly journals Asymmetric Catalysis Special Feature Part I: Mechanistic studies of the molybdenum-catalyzed asymmetric alkylation reaction

2004 ◽  
Vol 101 (15) ◽  
pp. 5379-5384 ◽  
Author(s):  
D. L. Hughes ◽  
G. C. Lloyd-Jones ◽  
S. W. Krska ◽  
L. Gouriou ◽  
V. D. Bonnet ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Alkylation Reaction ◽  
Mechanistic Studies ◽  
Asymmetric Alkylation
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