unsaturated ketones
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2022 ◽  
Vol 2022 (2) ◽  
Ping Jiang ◽  
Yaming Wang ◽  
Dengfeng Chen ◽  
Yu Zheng ◽  
Shenlin Huang

Synthesis ◽  
2022 ◽  
Kento Iwai ◽  
Haruka Yamauchi ◽  
Soichi Yokoyama ◽  
Nagatoshi Nishiwaki

Many biologically active nicotinonitriles have been reported to date. Consequently, the development of synthetic methods for multiply arylated/alkylated nicotinonitriles remains a sought-after field of research. In the present work, a new synthetic strategy for multi-substituted nicotinonitriles was provided. A FeCl3-promoted condensation-cyclization reaction of an enamino nitrile and α,β-unsaturated ketones efficiently proceeded with a wide range of substrates. It is noteworthy that this method facilitated the access to fully- and differently substituted nicotinonitriles including tetra-arylated nicotinonitriles in only three steps. Using the functionality of the cyano group, the copper-catalyzed annulation reaction of the nicotinonitrile was achieved to yield benzo[c][2,7]naphthyridin-5(6H)-one.

Ashwini Kadaji Nakate ◽  
Sagar Sudam Thorat ◽  
Shailja Jain ◽  
Rama Krishna Gamidi ◽  
Kumar Vanka ◽  

An unprecedented Ag(I)-catalyzed [3+3]-annulation of alkynyl alcohols (5-hexyn-1-ols) and α,β-unsaturated ketones is reported to construct simple to complex chromanes. This transformation begins with hydroalkoxylation of alkynol through C-C triple bond...

Kaixia Jian ◽  
Bingnan Li ◽  
Shuxian Zhu ◽  
Qingqing Xuan ◽  
Qiuling Song

Chemoselective reductions of α, β-unsaturated ketones to afford the corresponding allylic alcohols have always been challenging. Precious metals and ligands have always been employed in these transformations. Herein, we described...

2022 ◽  
Vol 1247 ◽  
pp. 131337
Maike Andresen ◽  
Martin Schwell ◽  
Ha Vinh Lam Nguyen

2022 ◽  
pp. 153627
Xiaolan Jiang ◽  
Xiaofeng Cui ◽  
Jinxun Chen ◽  
Qixing Liu ◽  
Yongsheng Chen ◽  

2021 ◽  
Xuemei Wang ◽  
Liang Zhou ◽  
Hongkui Zhang ◽  
Xiaoyu Ren ◽  
Guowei Gao ◽  
Ion Pair ◽  

Chaithra R. Shetty ◽  
L. Dikshith ◽  
Fathima Sible Dsouza ◽  
Fathimath Shahana ◽  
Fatima Nooha

Chalcone is a simple chemical structure which is present in most of the naturally occurring substances. Many chalcone derivatives are synthesized by Claisen-Schmidt condensation reaction. It is a subject of great research opportunity due to numerous biological activities and convenient synthesis of chalcones. This study aims on synthesizing different α, β unsaturated ketones (chalcones) containing thiophene from thiophene-2-carbaxldehyde and different substituted acetophenones, further evaluating antibacterial activity of synthesized compounds. The synthesized compounds are characterized for their spectral study. From the antibacterial study it was observed that the compounds bearing electron withdrawing group, electron releasing group exhibited excellent to moderate antibacterial activity respectively. These results showed that chalcones incorporated with thiophene have better scopes for further development of the antimicrobial agents.

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