Enzyme-substrate binding interactions of NADPH-cytochrome P-450 oxidoreductase characterized with pH and alternate substrate/inhibitor studies

Biochemistry ◽

10.1021/bi00094a010 ◽

1993 ◽

Vol 32 (43) ◽

pp. 11539-11547 ◽

Author(s):

Daniel S. Sem ◽

Charles B. Kasper

Keyword(s):

Substrate Binding ◽

Binding Interactions ◽

Nadph Cytochrome ◽

Enzyme Substrate ◽

Alternate Substrate ◽

Substrate Inhibitor ◽

Cytochrome P 450

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Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)83274-4 ◽

1989 ◽

Vol 264 (13) ◽

pp. 7584-7589 ◽

Author(s):

A L Shen ◽

T D Porter ◽

T E Wilson ◽

C B Kasper

Keyword(s):

Structural Analysis ◽

Binding Domain ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Nadph Cytochrome ◽

Cytochrome P 450

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Preparation and characterization of FAD-dependent NADPH-cytochrome P-450 reductase.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)57476-2 ◽

1986 ◽

Vol 261 (17) ◽

pp. 7824-7830

Author(s):

G P Kurzban ◽

H W Strobel

Keyword(s):

Nadph Cytochrome ◽

Cytochrome P 450

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Transcriptional regulation of rat liver epoxide hydratase, NADPH-Cytochrome P-450 oxidoreductase, and cytochrome P-450b genes by phenobarbital.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(20)82030-4 ◽

1983 ◽

Vol 258 (13) ◽

pp. 8081-8085 ◽

Author(s):

J P Hardwick ◽

F J Gonzalez ◽

C B Kasper

Keyword(s):

Transcriptional Regulation ◽

Rat Liver ◽

Nadph Cytochrome ◽

Epoxide Hydratase ◽

Cytochrome P 450

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Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)89763-0 ◽

1985 ◽

Vol 260 (1) ◽

pp. 515-521 ◽

Author(s):

D L Simmons ◽

P A Lalley ◽

C B Kasper

Keyword(s):

Gene Families ◽

Mixed Function Oxidase ◽

Oxidase System ◽

Nadph Cytochrome ◽

Genetic Localization ◽

Epoxide Hydratase ◽

Mixed Function Oxidase System ◽

Cytochrome P 450

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Structural analysis of NADPH-cytochrome P-450 reductase from porcine hepatic microsomes. Sequences of proteolytic fragments, cysteine-containing peptides, and a NADPH-protected cysteine peptide.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)89802-7 ◽

1984 ◽

Vol 259 (22) ◽

pp. 13703-13711

Author(s):

M Haniu ◽

T Iyanagi ◽

K Legesse ◽

J E Shively

Keyword(s):

Structural Analysis ◽

Nadph Cytochrome ◽

Hepatic Microsomes ◽

Cytochrome P 450

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Studies on the association of cytochrome P-450 and NADPH-cytochrome c reductase during catalysis in a reconstituted hydroxylating system.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)50470-1 ◽

1979 ◽

Vol 254 (13) ◽

pp. 5695-5700 ◽

Author(s):

G T Miwa ◽

S B West ◽

M T Huang ◽

A Y Lu

Keyword(s):

Cytochrome C ◽

Cytochrome C Reductase ◽

Nadph Cytochrome ◽

Cytochrome P 450 ◽

Nadph Cytochrome C Reductase

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Localization of cytochrome c-binding domain on NADPH-cytochrome P-450 reductase.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)67009-7 ◽

1986 ◽

Vol 261 (30) ◽

pp. 14232-14239

Author(s):

Y Nisimoto

Keyword(s):

Cytochrome C ◽

Binding Domain ◽

Nadph Cytochrome ◽

Cytochrome P 450

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Azaperone and the Hepatic Microsomes : Effects on Cytochrome P-450 Concentration and on NADPH-Cytochrome c-Reductase Activity

Acta Pharmacologica et Toxicologica ◽

10.1111/j.1600-0773.1973.tb01472.x ◽

2009 ◽

Vol 32 (3-4) ◽

pp. 285-288

Author(s):

Tho J. Pekkanen ◽

Kalevi Salminen

Keyword(s):

Cytochrome C ◽

Reductase Activity ◽

Cytochrome C Reductase ◽

Nadph Cytochrome ◽

Hepatic Microsomes ◽

Cytochrome P 450 ◽

Nadph Cytochrome C Reductase

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Methene bridge carbon atom elimination in oxidative heme degradation catalyzed by heme oxygenase and NADPH-cytochrome P-450 reductase

Archives of Biochemistry and Biophysics ◽

10.1016/0003-9861(84)90241-8 ◽

1984 ◽

Vol 235 (2) ◽

pp. 657-664 ◽

Author(s):

John C. Docherty ◽

Gay D. Firneisz ◽

Brent A. Schacter

Keyword(s):

Carbon Atom ◽

Heme Oxygenase ◽

Nadph Cytochrome ◽

Heme Degradation ◽

Bridge Carbon ◽

Cytochrome P 450

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Interaction of liver microsomal cytochrome P-450 and NADPH-cytochrome P-450 reductase in the presence and absence of lipid.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)39710-7 ◽

1984 ◽

Vol 259 (13) ◽

pp. 8174-8182 ◽

Author(s):

D Müller-Enoch ◽

P Churchill ◽

S Fleischer ◽

F P Guengerich

Keyword(s):

Microsomal Cytochrome ◽

Nadph Cytochrome ◽

Presence And Absence ◽

Cytochrome P 450

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