Evidence for a cellular ribonucleic acid synthesis inhibitor from poliovirus-infected HeLa cells

Biochemistry ◽  
1971 ◽  
Vol 10 (20) ◽  
pp. 3646-3651 ◽  
Author(s):  
Peter P. K. Ho ◽  
Anna L. Washington
Nature ◽  
1965 ◽  
Vol 207 (5000) ◽  
pp. 974-975 ◽  
Author(s):  
J. H. KIM ◽  
A. G. PEREZ

1991 ◽  
Vol 74 (6) ◽  
pp. 940-943 ◽  
Author(s):  
Taku Shigeno ◽  
Tatsuo Mima ◽  
Masashi Yanagisawa ◽  
Akira Saito ◽  
Katsutoshi Goto ◽  
...  

✓ The role of endothelin, a newly found vasoconstrictor peptide, is examined in the pathogenesis of cerebral vasospasm after experimental subarachnoid hemorrhage (SAH) in the dog. Endothelin immunoreactivity was overexpressed in the endothelium of the vasospastic basilar artery. Because endothelin synthesis is regulated at the messenger ribonucleic acid transcription level, the effect of actinomycin D, a ribonucleic acid synthesis inhibitor, was studied as a means of preventing vasospasm. It was found that treatment with intravenous actinomycin D for 5 days beginning on the day of SAH completely inhibited the development of vasospasm. This novel experimental therapy may lead not only to the elucidation of the pathogenesis of cerebral vasospasm but also to the availability of a prophylactic adjuvant therapy for patients with SAH.


1988 ◽  
Vol 158 (4) ◽  
pp. 762-767 ◽  
Author(s):  
Vicki V. Baker ◽  
Hugh M. Shingleton ◽  
Kenneth D. Hatch ◽  
Donald M. Miller

1970 ◽  
Vol 245 (10) ◽  
pp. 2679-2692
Author(s):  
David A. Sirbasku ◽  
John M. Buchanan

1970 ◽  
Vol 245 (9) ◽  
pp. 2309-2318 ◽  
Author(s):  
Michael Cashel ◽  
Barbara Kalbacher

1974 ◽  
Vol 249 (6) ◽  
pp. 1787-1791
Author(s):  
S.P. Mahadik ◽  
B. Dharmgrongartama ◽  
P.R. Srinivasan

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