scholarly journals A Solid-Phase, Library Synthesis of Natural-Product-Like Derivatives from an Enantiomerically Pure Tetrahydroquinoline Scaffold

2004 ◽  
Vol 6 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Samuel Couve-Bonnaire ◽  
Doug T. H. Chou ◽  
Zhonghong Gan ◽  
Prabhat Arya
Keyword(s):  
Natural Product ◽  
Solid Phase ◽  
Library Synthesis ◽  
Enantiomerically Pure

Microwave-Assisted Solid-Phase Synthesis (MASS): Parallel and Combinatorial Chemical Library Synthesis

ChemInform ◽  
2004 ◽  
Vol 35 (7) ◽  
Author(s):  
Fahad Al-Obeidi ◽  
Richard E. Austin ◽  
John F. Okonya ◽  
Daniel R. S. Bond
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Library Synthesis ◽  
Chemical Library ◽  
Phase Synthesis ◽  
Microwave Assisted

Advances in Solution- and Solid-Phase Synthesis toward the Generation of Natural Product-like Libraries

2009 ◽  
Vol 109 (5) ◽  
pp. 1999-2060 ◽  
Author(s):  
Jyoti P. Nandy ◽  
Michael Prakesch ◽  
Shahriar Khadem ◽  
P. Thirupathi Reddy ◽  
Utpal Sharma ◽  
...  
Keyword(s):  
Natural Product ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Use of in situ solid-phase adsorption in microbial natural product fermentation development

2013 ◽  
Vol 40 (5) ◽  
pp. 411-425 ◽  
Author(s):  
Thomas Phillips ◽  
Matthew Chase ◽  
Stephanie Wagner ◽  
Chris Renzi ◽  
Marcella Powell ◽  
...  
Keyword(s):  
Natural Product ◽  
Solid Phase ◽  
Solid Phase Adsorption

Studies Toward the Total Synthesis and Stereochemical Assignment of Microspinosamide

2015 ◽  
Vol 68 (12) ◽  
pp. 1885 ◽  
Author(s):  
Gajan Santhakumar ◽  
Richard J. Payne
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Chemical Ligation ◽  
Stereochemical Assignment ◽  
Linear Peptide ◽  
Cyclic Depsipeptide ◽  
Peptide Thioester ◽  
Structural Differences

Efforts toward the total synthesis and stereochemical assignment of the cyclic depsipeptide natural product microspinosamide are described. A single diastereoisomer was targeted corresponding to the predicted structure of the natural product incorporating a (2S, 3R)-β-hydroxy-p-bromophenylalanine residue. Assembly was achieved through the initial synthesis of a cyclic depsipeptide and a linear peptide thioester fragment by solid-phase peptide synthesis, followed by fusion of the two fragments through a native chemical ligation–oxidation protocol. Extensive spectroscopic analysis showed structural differences to the isolated natural product, suggesting that a diastereoisomer of microspinosamide had been synthesised. This work lays the foundation for the future synthesis of the correct diastereoisomer.

Solution- and Solid-Phase Synthesis of Natural Product-Like Tetrahydroquinoline-Based Polycyclics Having a Medium Size Ring

2004 ◽  
Vol 6 (5) ◽  
pp. 735-745 ◽  
Author(s):  
Prabhat Arya ◽  
Samuel Couve-Bonnaire ◽  
Patricia Durieux ◽  
Daisy Laforce ◽  
Rohtash Kumar ◽  
...  
Keyword(s):  
Natural Product ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Medium Size ◽  
Phase Synthesis
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