Directive effects in electrophilic aromatic substitution. An organic chemistry experiment

1972 ◽  
Vol 49 (2) ◽  
pp. 128 ◽  
Author(s):  
Robert R. Beishline
Keyword(s):  
Organic Chemistry ◽  
Electrophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Chemistry Experiment

scholarly journals An analysis of Electrophilic Aromatic Substitution: A “complex approach”

2020 ◽  
Author(s):  
Nikola Stamenković ◽  
N. P. Ulrih ◽  
Janez Cerkovnik
Keyword(s):  
Organic Chemistry ◽  
Electrophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Synthetic Organic Chemistry ◽  
Complex Approach

Electrophilic aromatic substitution (EAS) is one of the most widely researched transforms in synthetic organic chemistry. Numerous studies have been carried out to provide an understanding of the nature of...

Synthesis of new 5-bromo derivatives of indole and spiroindole phytoalexins

2015 ◽  
Vol 0 (0) ◽  
Author(s):  
Lucia Očenášová ◽  
Peter Kutschy ◽  
Jozef Gonda ◽  
Martina Pilátová ◽  
Gabriela Gönciová ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Cell Lines ◽  
Electrophilic Substitution ◽  
Electrophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Human Tumour ◽  
Leukaemia Cell ◽  
Tumour Cell Lines ◽  
Derivatives Of ◽  
Human Tumour Cell Lines

AbstractElectrophilic aromatic substitution is one of the most thoroughly studied reactions in organic chemistry. In the present paper, the 5-brominated spirobrassinol methyl ethers VII, VIII were obtained by electrophilic substitution of the aromatic core of indoline at the C-5 position in the presence of various brominating agents. The same products were also prepared from 5-bromoindole (IX ) following the sequence for the synthesis 1-methoxyspirobrassinol methyl ether (V) from indoline. In addition, the new related 5-bromospiroindoline derivatives XX-XXIII were synthesised and their biological activity on human tumour cell lines was examined. The presence of bromine in the indole or indoline skeleton at the C-5 position resulted in the partial increase in anticancer activity on leukaemia cell lines (Jurkat, CEM). The structures of the newly prepared products were determined by

Reactivity and selectivity of the methoxycarbonyl cation in gas-phase electrophilic aromatic substitution

1993 ◽  
Vol 97 (17) ◽  
pp. 4421-4426 ◽  
Author(s):  
Pierluigi Giacomello ◽  
Federico Pepi
Keyword(s):  
Gas Phase ◽  
Electrophilic Aromatic Substitution ◽  
Aromatic Substitution
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