14.alpha.-Ethyl-5.alpha.-cholest-7-ene-3.beta.,15.alpha.-diol, an extraordinarily potent inhibitor of sterol biosynthesis in animal cells

1977 ◽  
Vol 99 (16) ◽  
pp. 5494-5496 ◽  
Author(s):  
G. J. Schroepfer ◽  
E. J. Parish ◽  
A. A. Kandutsch
Keyword(s):  
Potent Inhibitor ◽  
Sterol Biosynthesis ◽  
Animal Cells

scholarly journals Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-substituted 15-oxygenated sterols.

1979 ◽  
Vol 20 (8) ◽  
pp. 994-998
Author(s):  
G J Schroepfer ◽  
E J Parish ◽  
M Tsuda ◽  
D L Raulston ◽  
A A Kandutsch
Keyword(s):  
Sterol Biosynthesis ◽  
Animal Cells

scholarly journals Inhibition of sterol biosynthesis in animal cells by 14 alpha-hydroxymethyl sterols.

1980 ◽  
Vol 21 (5) ◽  
pp. 571-584
Author(s):  
G J Schroepfer ◽  
E J Parish ◽  
R A Pascal ◽  
A A Kandutsch
Keyword(s):  
Sterol Biosynthesis ◽  
Animal Cells

7-Oxo-24ξ(28)-dihydrocycloeucalenol, a potent inhibitor of plant sterol biosynthesis

1982 ◽  
Vol 21 (8) ◽  
pp. 1969-1974 ◽  
Author(s):  
Alain Rahier ◽  
Paulette Schmitt ◽  
Pierre Benveniste
Keyword(s):  
Plant Sterol ◽  
Potent Inhibitor ◽  
Sterol Biosynthesis

7α,15β-Dichloro-5α-cholest-8(14)-en-3β-ol, a novel inhibitor of sterol biosynthesis in animal cells

1978 ◽  
Vol 84 (3) ◽  
pp. 823-829 ◽  
Author(s):  
George J. Schroepfer ◽  
Edward J. Parish ◽  
Gary L. Gilliland ◽  
Marcia E. Newcomer ◽  
Laura L. Sommerville ◽  
...  
Keyword(s):  
Sterol Biosynthesis ◽  
Animal Cells

Further studies on the inhibition of sterol biosynthesis in animal cells by 15-oxygenated sterols

1979 ◽  
Vol 25 (3) ◽  
pp. 265-285 ◽  
Author(s):  
George J. Schroepfer ◽  
Edward J. Parish ◽  
Andrew A. Kandutsch
Keyword(s):  
Sterol Biosynthesis ◽  
Animal Cells

Surface Structure of Nucleated Animal Cells: Carbon Replicas

1967 ◽  
Vol 25 ◽  
pp. 120-121
Author(s):  
Robert M. Glaeser ◽  
Thea B. Scott
Keyword(s):  
Cell Surface ◽  
Surface Structure ◽  
Particle Diameter ◽  
Cellular Functions ◽  
Animal Cells ◽  
Replica Technique ◽  
Carbon Replica ◽  
Characteristic Particle ◽  
Cell Surface Structure ◽  
Carbon Replicas

The carbon-replica technique can be used to obtain information about cell-surface structure that cannot ordinarily be obtained by thin-section techniques. Mammalian erythrocytes have been studied by the replica technique and they appear to be characterized by a pebbly or “plaqued“ surface texture. The characteristic “particle” diameter is about 200 Å to 400 Å. We have now extended our observations on cell-surface structure to chicken and frog erythrocytes, which possess a broad range of cellular functions, and to normal rat lymphocytes and mouse ascites tumor cells, which are capable of cell division. In these experiments fresh cells were washed in Eagle's Minimum Essential Medium Salt Solution (for suspension cultures) and one volume of a 10% cell suspension was added to one volume of 2% OsO4 or 5% gluteraldehyde in 0.067 M phosphate buffer, pH 7.3. Carbon replicas were obtained by a technique similar to that employed by Glaeser et al. Figure 1 shows an electron micrograph of a carbon replica made from a chicken erythrocyte, and Figure 2 shows an enlarged portion of the same cell.

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