Condensations Brought about by Bases. VIII. The Conversion of Ethyl Benzoyldimethylacetate to Ethyl Benzoate and Ethyl Isobutyryl-isobutyrate in the Presence of Sodium Ethoxide and Triphenylmethane. The Reversibility of the Claisen Type of Condensation1

1940 ◽  
Vol 62 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Charles R. Hauser ◽  
Boyd E. Hudson
Keyword(s):  
Sodium Ethoxide ◽  
Ethyl Benzoate

An immunocytochemical study of maternal immunoglobulin localization in the suckling pig intestine

1990 ◽  
Vol 48 (3) ◽  
pp. 922-923
Author(s):  
László G. Kömüves ◽  
Donna S. Turner ◽  
Kathy S. McKee ◽  
Buford L. Nichols ◽  
Julian P. Heath
Keyword(s):  
Sodium Ethoxide ◽  
Intracellular Localization ◽  
Protein A ◽  
Tween 20 ◽  
Intestinal Epithelial ◽  
Immunocytochemical Study ◽  
Fish Skin ◽  
Newborn Piglets ◽  
Rabbit Igg ◽  
Fish Skin Gelatin

In this study we used colloidal gold probes to detect the intracellular localization of colostral immunoglobulins in intestinal epithelial cells of newborn piglets.Tissues were obtained from non-suckled newborn and suckled piglets aged between 1 hour to 1 month. Samples were fixed in 2.5 % glutaraldehyde, osmicated and embedded into Spurr’s resin. Thin (80 nm) sections were etched with 5% sodium ethoxide for 5 min, washed and treated with 4 % sodium-m-periodate in distilled water for 30 min. The sections were then first incubated with blocking buffer (2 % BSA, 0.25 % fish skin gelatin, 0.5 % Tween 20 in 10 mM Trizma buffer, pH=7.4 containing 500 mM NaCl) for 30 min followed by the immunoreagents diluted in the same buffer, 1 hr each. For the detection of pig immunoglobulins a rabbit anti-pig IgG antiserum was used followed by goat anti-rabbit IgG-Au10 or protein A-Au15 probes.

XXXI.—Studies in the penthian series. Part I. The action of sodium ethoxide on ethyl β-thiodipropionate

1927 ◽  
Vol 0 (0) ◽  
pp. 194-200 ◽  
Author(s):  
George Macdonald Bennett ◽  
Leslie Vivian Donald Scorah
Keyword(s):  
Sodium Ethoxide

Reactions of 1,1-diaryl-2-halogenoethylenes with sodium ethoxide. Part V. Reactivity of pp′-dinitro-derivatives

1967 ◽  
Vol 0 (0) ◽  
pp. 1103-1108 ◽  
Author(s):  
P. Beltrame ◽  
P. L. Beltrame ◽  
O. Sighinolfi ◽  
M. Simonetta
Keyword(s):  
Sodium Ethoxide

Investigation on the Isobaric Vapor–Liquid Equilibrium for the Binary Systems of Ethyl Benzoate with Xylene Isomers and Ethylbenzene

2021 ◽  
Author(s):  
Jiahai Ding ◽  
Wei Guan ◽  
Leiyu Zhang ◽  
Xiudong Zhang ◽  
Chundong Zhang ◽  
...  
Keyword(s):  
Binary Systems ◽  
Ethyl Benzoate ◽  
Liquid Equilibrium ◽  
Vapor Liquid Equilibrium ◽  
Xylene Isomers ◽  
Vapor Liquid

ChemInform Abstract: KINETIC STUDY OF E2 ELIMINATIONS FROM 2-THIENYLETHYL BROMIDES AND TOLUENE-P-SULPHONATES PROMOTED BY SODIUM ETHOXIDE IN ETHANOL

1975 ◽  
Vol 6 (38) ◽  
pp. no-no
Author(s):  
ENRICO BACIOCCHI ◽  
VITTORIO MANCINI ◽  
PIERO PERUCCI
Keyword(s):  
Kinetic Study ◽  
Sodium Ethoxide

scholarly journals catena-Poly[[trimethyltin(IV)]-μ-methylphenylphosphinato-κ2O:O′]

IUCrData ◽  
2017 ◽  
Vol 2 (10) ◽  
Author(s):  
Chunhua Fu ◽  
Rufen Zhang ◽  
Shaoliang Zhang
Keyword(s):  
Solid State ◽  
Coordination Polymer ◽  
Title Compound ◽  
Sodium Ethoxide ◽  
Chain Structure ◽  
Polymeric Chain ◽  
One Dimensional ◽  
Trigonal Bipyramidal ◽  
Trimethyltin Chloride ◽  
Distorted Trigonal Bipyramidal

A new trimethyltin(IV) coordination polymer, [Sn(CH3)3(C7H8O2P)], has been prepared by treatment of methylphenylphosphinic acid and trimethyltin chloride with sodium ethoxide in methanol. In the solid state, the title compound adopts an infinite one-dimensional polymeric chain structure with each SnIVatom adopting a distorted trigonal–bipyramidal geometry.

scholarly journals Crystal structures of salts of bedaquiline

2020 ◽  
Vol 76 (11) ◽  
pp. 1010-1023
Author(s):  
Mercy Okezue ◽  
Daniel Smith ◽  
Matthias Zeller ◽  
Stephen R. Byrn ◽  
Pamela Smith ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Water Molecule ◽  
Salt Water ◽  
Sodium Ethoxide ◽  
New Drugs ◽  
Free Base ◽  
Dimethylamino Group ◽  
Patent Literature ◽  
Independent Molecules ◽  
Hydrogen Bonded

Bedaquiline [systematic name: 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol, C32H31BrN2O2] is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). It is marketed in the US as its fumarate salt {systematic name: [4-(6-bromo-2-methoxyquinolin-3-yl)-3-hydroxy-3-(naphthalen-1-yl)-4-phenylbutyl]dimethylazanium 3-carboxyprop-2-enoate, C32H32BrN2O2 +·C4H3O4 −}, and about a dozen other salts of bedaquiline have been described in patent literature, but none have so far been structurally described. In a first communication, we present the crystal structure of bedaquilinium fumarate and of two new benzoate salts, as well as that of a degradation product of the reaction of bedaquilinium fumarate with sodium ethoxide, 3-benzyl-6-bromo-2-methoxyquinoline, C17H14BrNO. The fumarate and benzoate salts both feature cations monoprotonated at the dimethylamino group. The much less basic quinoline N atom remains unprotonated. Both salts feature a 1:1 cation-to-anion ratio, with the fumarate being present as monoanionic hydrofumarate. The conformations of the cations are compared to that of free base bedaquiline and with each other. The flexible backbone of the bedaquiline structure leads to a landscape of conformations with little commonalities between the bedaquiline entities in the various structures. The conformations are distinctively different for the two independent molecules of the free base, the two independent molecules of the hydrofumarate salt, and the one unique cation of the benzoate salt. Packing of the salts is dominated by hydrogen bonding. Hydrogen-bonding motifs, as well as the larger hydrogen-bonded entities within the salts, are quite similar for the salts, despite the vastly differing conformations of the cations, and both the hydrofumarate and the benzoate structure feature chains of hydrogen-bonded anions that are surrounded by and hydrogen bonded to the larger bedaquilinium cations, leading to infinite broad ribbons of anions, cations, and (for the benzoate salt) water molecules. The benzoate salt was isolated in two forms: as a 1.17-hydrate (C32H32BrN2O2 +·C7H5O2 −·1.166H2O), obtained from acetone or propanol solution, with one fully occupied water molecule tightly integrated into the hydrogen-bonding network of anions and cations, and one partially occupied water molecule [refined occupancy 16.6 (7)%], only loosely hydrogen bonded to the quinoline N atom. The second form is an acetonitrile solvate (C32H32BrN2O2 +·C7H5O2 −·0.742CH3CN·H2O), in which the partially occupied water molecule is replaced by a 74.2 (7)%-occupied acetonitrile molecule. The partial occupancy induces disorder for the benzoate phenyl ring. The acetonitrile solvate is unstable in atmosphere and converts into a form not distinguishable by powder XRD from the 1.17-hydrate.

Mechanism of the expulsion of oh from the [M  C2H4]+˙ ion from ethyl benzoate

1970 ◽  
Vol 3 (10) ◽  
pp. 1333-1340 ◽  
Author(s):  
Robert H. Shapiro ◽  
Kenneth B. Tomer ◽  
Richard M. Caprioli ◽  
John H. Beynon
Keyword(s):  
Ethyl Benzoate
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