Background:
Asymmetric catalysis holds a prestigious role in organic syntheses since a long
time and chiral inductors such as ligands have been used to achieve the utmost desired results
at this pitch. The asymmetric version of Tsuji-Trost allylation has played a crucial
role in enantioselective synthesis. Various chiral ligands have been known for Pdcatalyzed
Asymmetric Allylic Alkylation (AAA) reactions and exhibited excellent catalytic
potential. The use of chiral ligands as asymmetric inductors has widened the scope of
Tsuji-Trost allylic alkylation reactions.
Conclusion:
Therefore, in this review article, a variety of chiral inductors or ligands have been focused
for palladium catalyzed asymmetric allylic alkylation (Tsuji-Trost allylation) and in this
regard, recently reported literature (2013-2017) has been described. The use of ligands
causes the induction of enantiodiscrimination to the allylated products, therefore, the syntheses of various kinds
of ligands have been targeted by many research groups to employ in Pd-catalyzed AAA reactions.
Enantioselective Synthesis of α-Tertiary Hydroxyaldehydes by Palladium-Catalyzed Asymmetric Allylic Alkylation of Enolates