Fermented Antrodia cinnamomea Extract Protects Rat PC12 Cells from Serum Deprivation-Induced Apoptosis: The Role of the MAPK Family†

2008 ◽  
Vol 56 (3) ◽  
pp. 865-874 ◽  
Author(s):  
Mei-Kuang Lu ◽  
Jing-Jy Cheng ◽  
Wen-Lin Lai ◽  
Yen-Ju Lin ◽  
Nai-Kuei Huang
Keyword(s):  
Pc12 Cells ◽  
Serum Deprivation ◽  
Antrodia Cinnamomea ◽  
Induced Apoptosis

Flow cytometric analysis of serum deprivation-induced apoptosis of PC12 cells, with special reference to role of bcl-2

1995 ◽  
Vol 201 (2) ◽  
pp. 119-122 ◽  
Author(s):  
Takumi Satoh ◽  
Naoto Sakai ◽  
Takekazu Kubo ◽  
Yasushi Enokido ◽  
Yasuo Uchiyama ◽  
...  
Keyword(s):  
Special Reference ◽  
Pc12 Cells ◽  
Flow Cytometric Analysis ◽  
Serum Deprivation ◽  
Flow Cytometric ◽  
Induced Apoptosis

scholarly journals Nitric Oxide Protects PC12 Cells from Serum Deprivation-Induced Apoptosis by cGMP-Dependent Inhibition of Caspase Signaling

1999 ◽  
Vol 19 (16) ◽  
pp. 6740-6747 ◽  
Author(s):  
Young-Myeong Kim ◽  
Hun-Taeg Chung ◽  
Sung-Soo Kim ◽  
Jeong-A Han ◽  
Yeong-Min Yoo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pc12 Cells ◽  
Serum Deprivation ◽  
Dependent Inhibition ◽  
Induced Apoptosis

scholarly journals Role of Apoptosis Signal-Regulating Kinase in Regulation of the c-Jun N-Terminal Kinase Pathway and Apoptosis in Sympathetic Neurons

2000 ◽  
Vol 20 (1) ◽  
pp. 196-204 ◽  
Author(s):  
Takashi Kanamoto ◽  
Monica Mota ◽  
Kohsuke Takeda ◽  
Lee L. Rubin ◽  
Kohei Miyazono ◽  
...  
Keyword(s):  
Map Kinase ◽  
Pc12 Cells ◽  
Neuronal Apoptosis ◽  
Sympathetic Neurons ◽  
Active Form ◽  
P38 Map Kinase ◽  
Differentiated Pc12 Cells ◽  
Mitogen Activated Protein ◽  
Induced Apoptosis

ABSTRACT We have previously shown that nerve growth factor (NGF) withdrawal-induced death requires the activity of the small GTP-binding protein Cdc42 and that overexpression of an active form of Cdc42 is sufficient to mediate neuronal apoptosis via activation of the c-Jun pathway. Recently, a new mitogen-activated protein (MAP) kinase kinase kinase, apoptosis signal-regulating kinase 1 (ASK1) which activates both the c-Jun N-terminal kinase (JNK) and p38 MAP kinase pathways and plays pivotal roles in tumor necrosis factor- and Fas-induced apoptosis, has been identified. Therefore, we investigated the role of ASK1 in neuronal apoptosis by using rat pheochromocytoma (PC12) neuronal cells and primary rat sympathetic neurons (SCGs). Overexpression of ASK1-ΔN, a constitutively active mutant of ASK1, activated JNK and induced apoptosis in differentiated PC12 cells and SCG neurons. Moreover, in differentiated PC12 cells, NGF withdrawal induced a four- to fivefold increase in the activity of endogenous ASK1. Finally, expression of a kinase-inactive ASK1 significantly blocked both NGF withdrawal- and Cdc42-induced death and activation of c-jun. Taken together, these results demonstrate that ASK1 is a crucial element of NGF withdrawal-induced activation of the Cdc42–c-Jun pathway and neuronal apoptosis.

Role of the mitochondrial pathway in serum deprivation-induced apoptosis of rat endplate cells

2014 ◽  
Vol 452 (3) ◽  
pp. 354-360 ◽  
Author(s):  
Defang Li ◽  
Bin Zhu ◽  
Lei Ding ◽  
Wei Lu ◽  
Guoxiong Xu ◽  
...  
Keyword(s):  
Mitochondrial Pathway ◽  
Serum Deprivation ◽  
Induced Apoptosis

28 The role of c-Jun N-terminal kinase activation in ceramide-induced apoptosis in PC12 cells

1998 ◽  
Vol 26 (4) ◽  
pp. S327-S327 ◽  
Author(s):  
Perry J. Hartfield ◽  
Andrea J. Bilney ◽  
Andrew W. Murray
Keyword(s):  
Pc12 Cells ◽  
Kinase Activation ◽  
Induced Apoptosis

Role of hsp105 in Protection against Stress-Induced Apoptosis in Neuronal PC12 Cells

2001 ◽  
Vol 288 (3) ◽  
pp. 528-534 ◽  
Author(s):  
Takumi Hatayama ◽  
Nobuyuki Yamagishi ◽  
Etsuko Minobe ◽  
Kayo Sakai
Keyword(s):  
Pc12 Cells ◽  
Neuronal Pc12 Cells ◽  
Induced Apoptosis
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