active component
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2022 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Chirato Godana Korra

Purpose This paper aims to prevent cotton textiles from fungi damage using eco-friendly aloe vera leaf extract, which was applied at a minimum amount, and cost-effective material. Design/methodology/approach Batch extraction method using methanol solvent; phytochemical analysis was investigated and three-level factorial design of experiment and analysis of variance (ANOVA) was used for the optimization of 27 test runs. The finish was applied by pad-dry-cue at distinct concentrations, and the chemical property after treatment was studied. Colorfastness and coordinates are analyzed. Cotton fabrics were cultured with Fusarium oxysporum fungi and the anti-fungal property was examined and reported according to AATCC 30–2004 standard. Findings The maximum yield of extract was at an optimum volume of 200 ml, 65 °C for 120 min. The effective antifungal fabric was achieved with minimum concentrations. There was significant strength loss in warp and weft direction. The treatment results in yellow-colored cotton fabric with fastness grade 3. The antifungal effect is durable until fifteen washes as the tensile strength losses were less than 1%. Research limitations/implications The findings of this work were based on samples considered in the laboratory. However, it can be reproducible at the factory production scale the treatment has the potential of yielding yellow dyed cotton fabric with multifunctional finishing. Practical implications The treated fabric is against Fusarium oxysporum Fungi which is one of the vital antimicrobial properties of textile apparel products for various areas of application. Social implications The natural extract material applied to a textile material is eco-friendly effective against microbes of cotton seeds during cultivation and apparel end-uses. Originality/value The work application of fungi resistance on cotton fabric using aloe vera active component was original; this work provides extraction of the active agent from aloe vera leaf, which is optimized statically and successfully applied for anti-fungal activity on cotton fabric.


2022 ◽  
Vol 7 (1) ◽  
pp. 17-22
Author(s):  
Alena Luptáková

The sulphate-reducing bacteria represent the part of the biosphere, the active component in the cycle of elements in the biosphere and as shown by the existing knowledge they are becoming also the part of the environmental industrial technologies. The objective of this work was to give principal information concerning characteristics, the occurrence and the importance of sulphate-reducing bacteria in environment.


2022 ◽  
Author(s):  
Zaid Abdul Khalik ◽  
Zeyad Saleh ◽  
Mazin Ali

Abstract In this research paper, a method built on UV/VIS spectrofluorophotometer and spectrophotometer by finding the fluorescence of glycyrrhizic acid in licorice root. Glycyrrhizic acid is an imperative active component present in licorice (Glycyrrhiza uralensis Fisch). Solvent effect had been studied in different solvents like deionized water and methanol. The differences between them were explored by the glycyrrhizic acid absorption and emission spectra. Under work conditions, i.e. 100% methanol solvent, a liquid ratio concentration 10−2 to 10−5 g /mL and second solvent with same conditions 100% deionized water in the same concentrations ,was done. The effect of the solvent was significant by change the value for λmax. The result was validated for parameters confines for Ex (λ Excitation) in different solvents. The results of absorption spectra obey Beer-Lambert's law. Because of the same property of these solvents (protic), the absence of a significant difference in the absorption spectra are shown. From florescence spectra, the spectrum at concentration 10−4 is the best for both solvents..


Electronics ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 161
Author(s):  
Predrag B. Petrović

New current mode grounded memcapacitor emulator circuits are reported in this paper, based on a single voltage differencing transconductance amplifier-VDTA and two grounded capacitors. The proposed circuits possess a single active component matching constraint, while the MOS-capacitance can be used instead of classical capacitance in a situation involving the simulator working within a high frequency range of up to 50 MHz, thereby offering obvious benefits in terms of realization utilising an IC-integrated circuit. The proposed emulator offers a variable switching mechanism—soft and hard—as well as the possibility of generating a negative memcapacitance characteristic, depending on the value of the frequency of the input current signal and the applied capacitance. The influence of possible non-ideality and parasitic effects was analysed, in order to reduce their side effects and bring the outcome to acceptable limits through the selection of passive elements. For the verification purposes, a PSPICE simulation environment with CMOS 0.18 μm TSMC technology parameters was selected. An experimental check was performed with off-the-shelf components-IC MAX435, showing satisfactory agreement with theoretical assumptions and conclusions.


Chemosensors ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Sarizhat D. Tataeva ◽  
Kurban E. Magomedov ◽  
Ruslan Z. Zeynalov ◽  
Naida D. Baygishieva ◽  
Viktorya S. Magomedova ◽  
...  

The technology for manufacturing a film membrane of the metamizole-selective electrode containing ion associate metamizole-octadecylammonium ODAH+MT− as an electrode active component (EAC) has been proposed. The main potentiometric characteristics of the metamizole-selective electrode have been determined. The expediency of the proposed design of the metamizole selective electrode for the determination of metamizole in dosage forms has been substantiated. The best composition of the membrane (wt.%) of the metamizole-selective electrode has corresponded to: ODAH+MT−—5.3; 2-nitrophenyloctylether—63.1; poly(vinyl chloride)—31.6. Electrode-active component in the membrane phase functions as an ion associate ODAH+MT−. Potentiometric characteristics of metamizole-selective electrode have been determined, which corresponded to: linear range 1 × 10−2–1 × 10−4 with limit of detection 4.58 × 10−5 M, electrode function slope −48.5 mV/dec., working interval pH 4.5–7.3, response time 60 s. The potentiometric coefficients of selectivity of the metamizole-selective electrode with respect to various ions have been determined. The possibility of determining metamizole in a medicinal product has been tested. The results of the analyses show good agreement between the two methods (relative error less than 7.0%) with coefficients of variation less than 5% for MT-SE and iodometric methods.


Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 29
Author(s):  
Jie Xu ◽  
Ke Cao ◽  
Xuyun Liu ◽  
Lin Zhao ◽  
Zhihui Feng ◽  
...  

Inflammation is a complex biological defense system associated with a series of chronic diseases such as cancer, arthritis, diabetes, cardiovascular and neurodegenerative diseases. The extracts of pomegranate fruit and peel have been reported to possess health-beneficial properties in inflammation-associated chronic diseases. Punicalagin is considered to be the major active component of pomegranate extracts. In this review we have focused on recent studies into the therapeutic effects of punicalagin on inflammation-associated chronic diseases and the regulatory roles in NF-κB, MAPK, IL-6/JAK/STAT3 and PI3K/Akt/mTOR signaling pathways. We have concluded that punicalagin may be a promising therapeutic compound in preventing and treating inflammation-associated chronic diseases, although further clinical studies are required.


Author(s):  
E. Leterme ◽  
W. De Troyer ◽  
L. Renier

Scopolamine as a component of a magistral preparation causing visual hallucinations A 40-year-old patient had a first episode of visual hallucinations caused by the abuse of a magistral preparation containing scopolamine as an active component. The pharmacist used the outdated medicine as an over-the-counter (OTC) product. The patient was not aware of the potential risks in case of overuse. The overdose caused an isolated hallucinosis instead of hallucinations as a consequence of an anticholinergic syndrome. Firstly, it is important that the patient is sufficiently informed by the pharmacist concerning the delivered medication. Secondly, the doctor should actively inquire if the patient uses any OTC or magistral medicines. By doing this, rare clinical diseases caused by misuse of medication can be identified.


2021 ◽  
Vol 12 ◽  
Author(s):  
Dan He ◽  
Qiang Li ◽  
Guangli Du ◽  
Guofeng Meng ◽  
Jijia Sun ◽  
...  

Background: Guizhi has the pharmacological activity of anti-inflammatory. However, the effect mechanism of Guizhi against nephrotic syndrome (NS) remains unclear. A network pharmacological approach with experimental verification in vitro and in vivo was performed to investigate the potential mechanisms of Guizhi to treat NS.Methods: Active compounds and potential targets of Guizhi, as well as the related targets of NS were obtained from the public databases. The intersecting targets of Guizhi and NS were obtained through Venny 2.1.0. The key targets and signaling pathways were determined by protein-protein interaction (PPI), genes ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) analysis. And the overall network was constructed with Cytoscape. Molecular docking verification was carried out by AutoDock Vina. Finally, in vitro and in vivo experiments were performed to verify the mechanism of Guizhi to treat NS.Results: 63 intersecting targets were obtained, and the top five key targets mainly involed in NF- Kappa B and MAPK signaling pathway. In the overall network, cinnamaldehyde (CA) was the top one active compound with the highest degree value. The molecular docking showed that the top five key targets were of good binding activity with the active components of Guizhi. To in vitro experiment, CA, the main active component of Guizhi, inhibited the secretion of IL-1β, IL-6, TNF-α in LPS challenged RAW264.7 cells, and down regulated the protein expression of p-NF-κB p65 and p-p38 MAPK in LPS challenged RAW264.7 cells. In vitro experiment showed that, 24 urinary protein and renal function were increased in ADR group. To western blot, CA down regulated the protein expression of p-p38 MAPK in rats of adriamycin-induced nephropathy.Conclusion: CA might be the main active component of Guizhi to treat NS, and the underlying mechanism might mainly be achieved by inhibiting MAPK signaling pathway.


2021 ◽  
Vol 111 (12) ◽  
pp. 2194-2201
Author(s):  
John M. Young ◽  
Shauna L. Stahlman ◽  
Shawn S. Clausen ◽  
Mark L. Bova ◽  
James D. Mancuso

Objectives. To assess COVID-19 disparities in the active component US military with an emphasis on race and ethnicity. Methods. In this retrospective cohort study, we calculated the incidence of COVID-19 testing, infection, and hospitalization in the active component US military in calendar year 2020. Results. Overall, 61.3 per 100 population per year were tested for COVID-19, 10.4% of tests were positive, and 1.1% of infected individuals were hospitalized. Non-Hispanic Blacks and Hispanics had a rate of testing for COVID-19 similar to that of Whites but had a higher risk of infection (adjusted risk ratio [ARR] = 1.25 and 1.26, respectively) and hospitalization (ARR = 1.28 and 1.21, respectively). Conclusions. Although of lower magnitude than seen in civilian populations, racial and ethnic disparities in COVID-19 infection and hospitalizations exist in the US military despite universal eligibility for health care, similar rate of testing, and adjustment for comorbidities and other factors. Simply making health care coverage available may be insufficient to ensure health equity. Interventions to mitigate disparities in the US military should target the patient, provider, health care system, and society at large. (Am J Public Health. 2021;111(12):2194–2201. https://doi.org/10.2105/AJPH.2021.306527 )


Author(s):  
R. Alrouhayya ◽  
T.F. Sheshko ◽  
E.B. Markova ◽  
V.S. Boldyrev ◽  
A.A. Razvodova ◽  
...  

The low solubility of a biologically active substance in an aqueous medium is often the main reason for the reduced therapeutic effect of drugs. The most common approach to solve this problem is to obtain a watersoluble salt of the active substance and an appropriate preparatory formulation based on it. In this case, the solubility of the obtained compound in hydrophobic systems decreases dramatically, which decreases the rate of transmembrane transport and changes the pharmacokinetic laws of the process. In practice, not only the dependence of the therapeutic effect on the salt compound properties, but also a complete loss of the drug active ingredient activity can be observed. The use of biologically active compound solid dispersions in watersoluble polymers is the most promising approach to increase the therapeutic effect of drugs while maintaining the hydrophobic nature of the active component, to reduce the dose load on the patient’s body and obtain prolonged action. In experiments we obtained solid dispersions of mefenamic acid in polyvinylpyrrolidone and studied kinetic regularities of solubility of this promising drug form in aqueous solution of phosphate buffer. By means of mathematical modelling it was found that the phenomenon under study is well described by Ritger --- Peppas model, which considers diffusion of biologically active component into solution according to Fick's law with possible influence on mass transfer at swelling and degradation of polymer matrix


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