Design, Synthesis, and Structure–Activity Relationships of Novel Pyrazolo[5,1-b]thiazole Derivatives as Potent and Orally Active Corticotropin-Releasing Factor 1 Receptor Antagonists

Yoshinori Takahashi; Minako Hashizume; Kogyoku Shin; Taro Terauchi; Kunitoshi Takeda; Shigeki Hibi; Kaoru Murata-Tai; Masae Fujisawa; Kodo Shikata; Ryota Taguchi; Mitsuhiro Ino; Hisashi Shibata; Masahiro Yonaga

doi:10.1021/jm300864p

Design, Synthesis, and Structure–Activity Relationships of Novel Pyrazolo[5,1-b]thiazole Derivatives as Potent and Orally Active Corticotropin-Releasing Factor 1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm300864p ◽

2012 ◽

Vol 55 (19) ◽

pp. 8450-8463 ◽

Cited By ~ 9

Author(s):

Yoshinori Takahashi ◽

Minako Hashizume ◽

Kogyoku Shin ◽

Taro Terauchi ◽

Kunitoshi Takeda ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Thiazole Derivatives ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm040058e ◽

2004 ◽

Vol 47 (19) ◽

pp. 4787-4798 ◽

Cited By ~ 91

Author(s):

Chen ◽

Keith M. Wilcoxen ◽

Charles Q. Huang ◽

Yun-Feng Xie ◽

James R. McCarthy ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Corrigendum to “Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists” [Bioorg. Med. Chem. 22 (2014) 6071–6088]

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.04.042 ◽

2015 ◽

Vol 23 (13) ◽

pp. 3870

Author(s):

Yu Yoshida ◽

Taro Terauchi ◽

Yoshimitsu Naoe ◽

Yuji Kazuta ◽

Fumihiro Ozaki ◽

...

Keyword(s):

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Rational Design, Synthesis, and Structure−Activity Relationships of Aryltriazoles as Novel Corticotropin-Releasing Factor-1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm049339c ◽

2005 ◽

Vol 48 (5) ◽

pp. 1540-1549 ◽

Cited By ~ 16

Author(s):

Richard F. Lowe ◽

Jodene Nelson ◽

Trunghau N. Dang ◽

Paul D. Crowe ◽

Anil Pahuja ◽

...

Keyword(s):

Rational Design ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.08.034 ◽

2014 ◽

Vol 22 (21) ◽

pp. 6071-6088 ◽

Cited By ~ 12

Author(s):

Yu Yoshida ◽

Taro Terauchi ◽

Yoshimitsu Naoe ◽

Yuji Kazuta ◽

Fumihiro Ozaki ◽

...

Keyword(s):

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Synthesis and structure–activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.09.028 ◽

2012 ◽

Vol 20 (22) ◽

pp. 6559-6578 ◽

Cited By ~ 7

Author(s):

Kunitoshi Takeda ◽

Taro Terauchi ◽

Minako Hashizume ◽

Kohdoh Shikata ◽

Ryota Taguchi ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Design, Synthesis, and Structure−Activity Relationships of Thieno[2,3-b]pyridin-4-one Derivatives as a Novel Class of Potent, Orally Active, Non-Peptide Luteinizing Hormone-Releasing Hormone Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm0512894 ◽

2006 ◽

Vol 49 (13) ◽

pp. 3809-3825 ◽

Cited By ~ 13

Author(s):

Takashi Imada ◽

Nobuo Cho ◽

Toshihiro Imaeda ◽

Yoji Hayase ◽

Satoshi Sasaki ◽

...

Keyword(s):

Luteinizing Hormone ◽

Hormone Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Luteinizing Hormone Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Synthesis, structure–activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.05.117 ◽

2005 ◽

Vol 15 (17) ◽

pp. 3870-3873 ◽

Cited By ~ 14

Author(s):

Xiaojun Han ◽

Jodi A. Michne ◽

Sokhom S. Pin ◽

Kevin D. Burris ◽

Lynn A. Balanda ◽

...

Keyword(s):

Anxiolytic Activity ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-l-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid (CI-996)

Journal of Medicinal Chemistry ◽

10.1021/jm00068a002 ◽

1993 ◽

Vol 36 (16) ◽

pp. 2253-2265 ◽

Cited By ~ 9

Author(s):

Ila Sircar ◽

John C. Hodges ◽

John Quin ◽

Amy M. Bunker ◽

R. Thomas Winters ◽

...

Keyword(s):

Angiotensin Ii ◽

Carboxylic Acid ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity

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Design, synthesis and structure–Activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00371-2 ◽

2002 ◽

Vol 12 (16) ◽

pp. 2185-2187 ◽

Cited By ~ 16

Author(s):

Timothy D. Gross ◽

Yun-Fei Zhu ◽

John Saunders ◽

Keith M. Wilcoxen ◽

Yinghong Gao ◽

...

Keyword(s):

Gnrh Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure−Activity Relationships and Computational Modeling

Journal of Medicinal Chemistry ◽

10.1021/jm0611410 ◽

2007 ◽

Vol 50 (9) ◽

pp. 2269-2272 ◽

Cited By ~ 4

Author(s):

Carolyn D. Dzierba ◽

Andrew J. Tebben ◽

Richard G. Wilde ◽

Amy G. Takvorian ◽

Maria Rafalski ◽

...

Keyword(s):

Computational Modeling ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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