Rational Design, Synthesis, and Structure−Activity Relationships of Aryltriazoles as Novel Corticotropin-Releasing Factor-1 Receptor Antagonists

Richard F. Lowe; Jodene Nelson; Trunghau N. Dang; Paul D. Crowe; Anil Pahuja; James R. McCarthy; Dimitri E. Grigoriadis; Paul Conlon; John Saunders;  Chen; Thomas Szabo; Ta Kung Chen; Haig Bozigian

doi:10.1021/jm049339c

Rational Design, Synthesis, and Structure−Activity Relationships of Aryltriazoles as Novel Corticotropin-Releasing Factor-1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm049339c ◽

2005 ◽

Vol 48 (5) ◽

pp. 1540-1549 ◽

Cited By ~ 16

Author(s):

Richard F. Lowe ◽

Jodene Nelson ◽

Trunghau N. Dang ◽

Paul D. Crowe ◽

Anil Pahuja ◽

...

Keyword(s):

Rational Design ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Design, Synthesis, and Structure–Activity Relationships of Novel Pyrazolo[5,1-b]thiazole Derivatives as Potent and Orally Active Corticotropin-Releasing Factor 1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm300864p ◽

2012 ◽

Vol 55 (19) ◽

pp. 8450-8463 ◽

Cited By ~ 9

Author(s):

Yoshinori Takahashi ◽

Minako Hashizume ◽

Kogyoku Shin ◽

Taro Terauchi ◽

Kunitoshi Takeda ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Thiazole Derivatives ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm040058e ◽

2004 ◽

Vol 47 (19) ◽

pp. 4787-4798 ◽

Cited By ~ 91

Author(s):

Chen ◽

Keith M. Wilcoxen ◽

Charles Q. Huang ◽

Yun-Feng Xie ◽

James R. McCarthy ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Synthesis, structure–activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.05.117 ◽

2005 ◽

Vol 15 (17) ◽

pp. 3870-3873 ◽

Cited By ~ 14

Author(s):

Xiaojun Han ◽

Jodi A. Michne ◽

Sokhom S. Pin ◽

Kevin D. Burris ◽

Lynn A. Balanda ◽

...

Keyword(s):

Anxiolytic Activity ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-l-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid (CI-996)

Journal of Medicinal Chemistry ◽

10.1021/jm00068a002 ◽

1993 ◽

Vol 36 (16) ◽

pp. 2253-2265 ◽

Cited By ~ 9

Author(s):

Ila Sircar ◽

John C. Hodges ◽

John Quin ◽

Amy M. Bunker ◽

R. Thomas Winters ◽

...

Keyword(s):

Angiotensin Ii ◽

Carboxylic Acid ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity

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Corrigendum to “Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists” [Bioorg. Med. Chem. 22 (2014) 6071–6088]

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.04.042 ◽

2015 ◽

Vol 23 (13) ◽

pp. 3870

Author(s):

Yu Yoshida ◽

Taro Terauchi ◽

Yoshimitsu Naoe ◽

Yuji Kazuta ◽

Fumihiro Ozaki ◽

...

Keyword(s):

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Design, synthesis and structure–Activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00371-2 ◽

2002 ◽

Vol 12 (16) ◽

pp. 2185-2187 ◽

Cited By ~ 16

Author(s):

Timothy D. Gross ◽

Yun-Fei Zhu ◽

John Saunders ◽

Keith M. Wilcoxen ◽

Yinghong Gao ◽

...

Keyword(s):

Gnrh Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure−Activity Relationships and Computational Modeling

Journal of Medicinal Chemistry ◽

10.1021/jm0611410 ◽

2007 ◽

Vol 50 (9) ◽

pp. 2269-2272 ◽

Cited By ~ 4

Author(s):

Carolyn D. Dzierba ◽

Andrew J. Tebben ◽

Richard G. Wilde ◽

Amy G. Takvorian ◽

Maria Rafalski ◽

...

Keyword(s):

Computational Modeling ◽

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: Design, Synthesis, and Structure-Activity Relationships of Phthalimide-Phenylpiperazines: A Novel Series of Potent and Selective α1a-Adrenergic Receptor Antagonists.

ChemInform ◽

10.1002/chin.200037167 ◽

2000 ◽

Vol 31 (37) ◽

pp. no-no

Author(s):

Gee-Hong Kuo ◽

Catherine Prouty ◽

William V. Murray ◽

Virginia Pulito ◽

Linda Jolliffe ◽

...

Keyword(s):

Adrenergic Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Rational Design, Synthesis and Structure—Activity Relationships of a Cyclic Succinate Series of TNF-α Converting Enzyme Inhibitors. Part 1. Lead Identification.

ChemInform ◽

10.1002/chin.200414160 ◽

2004 ◽

Vol 35 (14) ◽

Author(s):

Chu-Biao Xue ◽

et al. et al.

Keyword(s):

Rational Design ◽

Enzyme Inhibitors ◽

Converting Enzyme ◽

Converting Enzyme Inhibitors ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Tnf Α ◽

Lead Identification

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Synthesis and structure–activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.01.129 ◽

2010 ◽

Vol 20 (6) ◽

pp. 1890-1894 ◽

Cited By ~ 15

Author(s):

Richard A. Hartz ◽

Vijay T. Ahuja ◽

William D. Schmitz ◽

Thaddeus F. Molski ◽

Gail K. Mattson ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Crf1 Receptor ◽

Structure Activity

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