In the Mindset of Opportunity: Proactive Mindset, Perceived Opportunities, and Role Attitudes

Perceiving roles as fulfilling goals offers motivational benefits to students, and yet the features of individuals or contexts that align with seeing such role opportunities have not been studied systematically. The current research investigated how these goal affordances are related to proactive mindset, or a person’s belief that they can shape their contexts. Three studies examined how variation in proactivity aligns with perceiving more communal and agentic goal opportunities in roles. Study 1 found that highly proactive college students (vs. less proactive students) tended to perceive their future careers as fulfilling communal and agentic goals, which predicted positive career attitudes. Study 2 replicated this association, while ruling out behavioral flexibility as accounting for the proactivity-positivity relationship. Study 3 experimentally tested whether growth-oriented contexts foster proactivity. Proactive mindset aligns with more expansive views of roles as fulfilling fundamental motives. These views, in turn, carry positive implications for one’s future career attitudes.

Design, Synthesis, and Structure–Activity Relationship Study of Potent MAPK11 Inhibitors

Huntington’s disease (HD) is a rare single-gene neurodegenerative disease, which can only be treated symptomatically. Currently, there are no approved drugs for HD on the market. Studies have found that MAPK11 can serve as a potential therapeutic target for HD. Regrettably, no MAPK11 small molecule inhibitors have been approved at present. This paper presents three series of compounds that were designed and synthesized based on the structure of skepinone-L, a known MAPK14 inhibitor. Among the synthesized compounds, 13a and 13b, with IC50 values of 6.40 nM and 4.20 nM, respectively, displayed the best inhibitory activities against MAPK11. Furthermore, the structure–activity relationship (SAR) is discussed in detail, which is constructive in optimizing the MAPK11 inhibitors for better activity and effect against HD.

Characterization of intron 7 to exon 8 of heat shock protein 90-aa1 (hsp90aa1) gene in dominant brown layer chicken using some bioinformatic tools

HSP90AA1, an isoform of HSP90 has been characterized to indicate it plays important roles in basic cellular events. It is activated in chicken in response to heat stress. This study was aimed at the computational analysis of the biochemical cum structural features and an evolutionary relationship study on the HSP90AA1 gene in Dominant brown layers (DBL) and some selected avian species using bioinformatics tools. ProtParam for physicochemical properties. Scanprosite for post-translational modification sites, Netphos-3.1 for phosphorylation sites, BDM-PUB program for Ubiquitination sites, PDBSUM for Secondary structure and homology modelling with SWISS-model. The findings revealed that intron 7 and exon 8 of HSP90AA1 protein in DBL had a molecular weight of 24681.19Da and an instability index of 27.60, contains N-myristoylation, Protein-kinase-C-phosphorylation and Tyrosine-kinase-phosphorylation site-2 post-translational modification sites, 4-serine and 2-threonine phosphorylation sites and 12-ubiquitination sites. The evolutionary relationship study found Japanese quail to be in a sister branch close to DBL and chicken. Motifs detected in the avian species revealed the gene to be highly conserved. The secondary structure consisted of 16-helices, 3-sheets and 14-strands. The homology modelling was 87.25% sequence identity with human MC-HSP90-alpha. The study elucidates the components and characteristics of HSP90AA1 in DBL in response to heat stress.

Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists

An expansion of the structure–activity relationship study of CXCR4 antagonists led to the synthesis of a series of isoquinolines, bearing a tetrahydroquinoline or a 3-methylpyridinyl moiety as head group. All compounds were investigated for CXCR4 affinity and antagonism in competition binding and calcium mobilization assays, respectively. In addition, the anti-HIV activity of all analogues was determined. All compounds showed excellent activity, with compound 24c being the most promising one, since it displayed consistently low nanomolar activity in the various assays.

In the Mindset of Opportunity: Proactive Mindset, Perceived Opportunities, and Role Attitudes

Perceiving roles as fulfilling goals offers motivational benefits to students, and yet the features of individuals or contexts that align with seeing such role opportunities have not been studied systematically. The current research investigated how these goal affordances are related to proactive mindset or a person’s belief that they can shape their contexts. Three studies examined how variation in proactivity aligns with perceiving more communal and agentic goal opportunities in roles. Study 1 found that highly proactive college students (vs. less proactive students) tended to perceive their future careers as fulfilling communal and agentic goals, which predicted positive career attitudes. Study 2 replicated this association, while ruling out behavioral flexibility as accounting for the proactivity–positivity relationship. Study 3 experimentally tested whether growth-oriented contexts foster proactivity. Proactive mindset aligns with more expansive views of roles as fulfilling fundamental motives. These views, in turn, carry positive implications for one’s future career attitudes.