Discovery of (−)-7-Methyl-2-exo-[3′-(6-[18F]fluoropyridin-2-yl)-5′-pyridinyl]-7-azabicyclo[2.2.1]heptane, a Radiolabeled Antagonist for Cerebral Nicotinic Acetylcholine Receptor (α4β2-nAChR) with Optimal Positron Emission Tomography Imaging Properties

Yongjun Gao; Hiroto Kuwabara; Charles E. Spivak; Yingxian Xiao; Kenneth Kellar; Hayden T. Ravert; Anil Kumar; Mohab Alexander; John Hilton; Dean F. Wong; Robert F. Dannals; Andrew G. Horti

doi:10.1021/jm800323d

Discovery of (−)-7-Methyl-2-exo-[3′-(6-[18F]fluoropyridin-2-yl)-5′-pyridinyl]-7-azabicyclo[2.2.1]heptane, a Radiolabeled Antagonist for Cerebral Nicotinic Acetylcholine Receptor (α4β2-nAChR) with Optimal Positron Emission Tomography Imaging Properties

Journal of Medicinal Chemistry ◽

10.1021/jm800323d ◽

2008 ◽

Vol 51 (15) ◽

pp. 4751-4764 ◽

Cited By ~ 17

Author(s):

Yongjun Gao ◽

Hiroto Kuwabara ◽

Charles E. Spivak ◽

Yingxian Xiao ◽

Kenneth Kellar ◽

...

Keyword(s):

Positron Emission Tomography ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Imaging Properties

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Synthesis and Evaluation of a Novel Series of 2-Chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine Analogues as Potential Positron Emission Tomography Imaging Agents for Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm010550n ◽

2002 ◽

Vol 45 (13) ◽

pp. 2841-2849 ◽

Cited By ~ 18

Author(s):

LaVerne L. Brown ◽

Santosh Kulkarni ◽

Olga A. Pavlova ◽

Andrei O. Koren ◽

Alexey G. Mukhin ◽

...

Keyword(s):

Positron Emission Tomography ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Imaging Agents ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Vinyl Pyridine

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ChemInform Abstract: Synthesis and Nicotinic Acetylcholine Receptor Binding Properties of exo-2-(2′-Fluoro-5′-pyridinyl)-7-azabicyclo(2.2.1)heptane: A New Positron Emission Tomography Ligand for Nicotinic Receptors.

ChemInform ◽

10.1002/chin.199745246 ◽

2010 ◽

Vol 28 (45) ◽

pp. no-no

Author(s):

F. LIANG ◽

H. A. NAVARRO ◽

P. ABRAHAM ◽

P. KOTIAN ◽

Y.-S. DING ◽

...

Keyword(s):

Positron Emission Tomography ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Nicotinic Receptors ◽

Emission Tomography ◽

Binding Properties ◽

Nicotinic Acetylcholine ◽

Positron Emission ◽

Positron Emission Tomography Ligand

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Synthesis and Nicotinic Acetylcholine Receptor Binding Properties ofexo-2-(2‘-Fluoro-5‘-pyridinyl)-7-azabicyclo- [2.2.1]heptane: A New Positron Emission Tomography Ligand for Nicotinic Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm970187d ◽

1997 ◽

Vol 40 (15) ◽

pp. 2293-2295 ◽

Cited By ~ 41

Author(s):

Feng Liang ◽

Hernán A. Navarro ◽

Philip Abraham ◽

Pravin Kotian ◽

Yu-Shin Ding ◽

...

Keyword(s):

Positron Emission Tomography ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Binding ◽

Nicotinic Receptors ◽

Emission Tomography ◽

Binding Properties ◽

Nicotinic Acetylcholine ◽

Positron Emission ◽

Positron Emission Tomography Ligand

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P2-390: Evaluating a novel alpha7 nicotinic acetylcholine receptor ligand [11C]CHIBA1001 for positron emission tomography

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.05.1442 ◽

2010 ◽

Vol 6 ◽

pp. S431-S431

Author(s):

Masatomo Ishikawa ◽

Kenji Ishii ◽

Jun Toyohara ◽

Muneyuki Sakata ◽

Keiichi Oda ◽

...

Keyword(s):

Positron Emission Tomography ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Emission Tomography ◽

Receptor Ligand ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Positron Emission

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Synthesis and Nicotinic Acetylcholine Receptor in Vivo Binding Properties of 2-Fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: A New Positron Emission Tomography Ligand for Nicotinic Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm9910223 ◽

1999 ◽

Vol 42 (12) ◽

pp. 2251-2259 ◽

Cited By ~ 97

Author(s):

Frédéric Dollé ◽

Lilian Dolci ◽

Héric Valette ◽

Françoise Hinnen ◽

Françoise Vaufrey ◽

...

Keyword(s):

Positron Emission Tomography ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Receptors ◽

Emission Tomography ◽

Binding Properties ◽

Nicotinic Acetylcholine ◽

Positron Emission ◽

Positron Emission Tomography Ligand

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5-Substituted Derivatives of 6-Halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-Halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with Low Picomolar Affinity for α4β2 Nicotinic Acetylcholine Receptor and Wide Range of Lipophilicity: Potential Probes for Imaging with Positron Emission Tomography

Journal of Medicinal Chemistry ◽

10.1021/jm030432v ◽

2004 ◽

Vol 47 (10) ◽

pp. 2453-2465 ◽

Cited By ~ 45

Author(s):

Yi Zhang ◽

Olga A. Pavlova ◽

Svetlana I. Chefer ◽

Andrew W. Hall ◽

Varughese Kurian ◽

...

Keyword(s):

Positron Emission Tomography ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Positron Emission ◽

Wide Range ◽

Lipophilicity Potential ◽

Derivatives Of

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Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer’s disease assessed with positron emission tomography

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-010-1644-5 ◽

2010 ◽

Vol 38 (3) ◽

pp. 515-525 ◽

Cited By ~ 78

Author(s):

Kai Kendziorra ◽

Henrike Wolf ◽

Philipp Mael Meyer ◽

Henryk Barthel ◽

Swen Hesse ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Positron Emission Tomography ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Positron Emission

Download Full-text

Derivatives of Dibenzothiophene for Positron Emission Tomography Imaging of α7-Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm401184f ◽

2013 ◽

Vol 56 (19) ◽

pp. 7574-7589 ◽

Cited By ~ 36

Author(s):

Yongjun Gao ◽

Kenneth J. Kellar ◽

Robert P. Yasuda ◽

Thao Tran ◽

Yingxian Xiao ◽

...

Keyword(s):

Positron Emission Tomography ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Derivatives Of

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6-Chloro-3-(((1-[11C]methyl)-2-(S)-pyrrolidinyl)methoxy)-5-(2-fluoropyridin-4-yl)pyridine ([11C]JHU85270), a potent ligand for nicotinic acetylcholine receptor imaging by positron emission tomography

Applied Radiation and Isotopes ◽

10.1016/j.apradiso.2007.04.013 ◽

2007 ◽

Vol 65 (8) ◽

pp. 947-951 ◽

Cited By ~ 6

Author(s):

Yongjun Gao ◽

Hayden T. Ravert ◽

Daniel Holt ◽

Robert F. Dannals ◽

Andrew G. Horti

Keyword(s):

Positron Emission Tomography ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Emission Tomography ◽

Receptor Imaging ◽

Nicotinic Acetylcholine ◽

Positron Emission

Download Full-text

Derivatives of (−)-7-Methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2.1]heptane Are Potential Ligands for Positron Emission Tomography Imaging of Extrathalamic Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm070224t ◽

2007 ◽

Vol 50 (16) ◽

pp. 3814-3824 ◽

Cited By ~ 8

Author(s):

Yongjun Gao ◽

Andrew G. Horti ◽

Hiroto Kuwabara ◽

Hayden T. Ravert ◽

John Hilton ◽

...

Keyword(s):

Positron Emission Tomography ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Derivatives Of

Download Full-text