Discovery of 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an Active Metabolite. A Novel, Potent and Selective Cannabinoid-1 Receptor Inverse Agonist with High Antiobesity Efficacy in DIO Mice

2009 ◽  
Vol 52 (14) ◽  
pp. 4496-4510 ◽  
Author(s):  
Chien-Huang Wu ◽  
Ming-Shiu Hung ◽  
Jen-Shin Song ◽  
Teng-Kuang Yeh ◽  
Ming-Chen Chou ◽  
...  
Keyword(s):  
Active Metabolite ◽  
Inverse Agonist ◽  
Cannabinoid 1 Receptor ◽  
Receptor Inverse Agonist

In vitroandin vivometabolism of a novel cannabinoid-1 receptor inverse agonist, taranabant, in rats and monkeys

Xenobiotica ◽  
2010 ◽  
Vol 40 (9) ◽  
pp. 650-662 ◽  
Author(s):  
V.B.G. Reddy ◽  
G.A. Doss ◽  
B.V. Karanam ◽  
K. Samuel ◽  
T.J. Lanza Jr ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Cannabinoid 1 Receptor ◽  
Receptor Inverse Agonist

Influence of taranabant, a cannabinoid-1 receptor inverse agonist, on pharmacokinetics and pharmacodynamics of warfarin

2008 ◽  
Vol 25 (11) ◽  
pp. 1175-1190 ◽  
Author(s):  
Jules I. Schwartz ◽  
Stephanie Dunbar ◽  
Jinyu Yuan ◽  
Susie Li ◽  
Adrianna Gipson ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Cannabinoid 1 Receptor ◽  
Receptor Inverse Agonist

Human Abuse Potential and Cognitive Effects of Taranabant, a Cannabinoid 1 Receptor Inverse Agonist

2012 ◽  
Vol 32 (4) ◽  
pp. 492-502 ◽  
Author(s):  
Kerri A. Schoedel ◽  
Carol Addy ◽  
Bijan Chakraborty ◽  
Kim Rosko ◽  
Stephanie Dunbar ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Abuse Potential ◽  
Cognitive Effects ◽  
Cannabinoid 1 Receptor ◽  
Receptor Inverse Agonist
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