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2022 ◽  
Vol 5 (1) ◽  
Author(s):  
Matthew Feeback ◽  
Bailey Reitsma

Introduction: To further understand the effects of L-arginine on both its ability to enhance lactate clearance and increase overall blood flow before, during, and after exhaustive anaerobic exercise. Methods:  Twelve healthy male subjects between the ages of 18-25 first completed an initial visit where baseline data was recorded. Subjects completed three additional visits, in which they ingested either a placebo, two-gram or four-gram dose of L-arginine. Blood flow (BF) and lactate were recorded before ingestion of the treatment, 5 and 15-minutes post-ingestion prior to performing a push-up test to volitional fatigue.  Immediately following the push-up test, BF and lactate were assessed and again 15-minutes post exercise. Results: Blood lactate did not differ across condition (p=0.569).  Lactate clearance was not influenced by L-arginine when analyzing the Area Under Curve.  Blood flow increased with ingestion of the four-gram dose while at rest (the 15-minute mark).  Blood flow was also enhanced in the four-gram dose immediately after exercise at the 25-minute mark.  Conclusions: The data suggests that a four-gram dose of L-arginine plays a more significant role in blood flow than the clearance of lactate after exercise compared to a two-gram dose or placebo.


2022 ◽  
Vol 27 (1) ◽  
Author(s):  
Xiaoqin Wu ◽  
Yuchuan Ding ◽  
Xunming Ji ◽  
Ran Meng

Abstract Purpose Unilateral jugular stenosis is easily mistaken as jugular hypoplasia for their similar jugular appearances. This study aimed to propose a scheme to differentiate acquired internal jugular vein stenosis (IJVS) from congenital jugular variation through two case examples. Methods We presented a dynamic evolution process of the IJVS formation, through a case of a 17-year-old female with paroxysmal nocturnal hemoglobinuria (PNH)-associated right internal jugular venous thrombosis (IJVT), which resulted in post-thrombotic IJVS in the rare context of rapid recanalization. Meanwhile, we compared her images with images of a 39-year-old healthy male with hypoplastic IJV to determine the differences between the acquired IJVS and congenital dysplasia. Results Based on the first case, we noticed the whole formative process of acquired IJVS from nothing to something. Meantime, we found that acquired IJVS was surrounded by abnormal corkscrew collaterals as imaged on contrast-enhanced magnetic resonance venography (CE-MRV), and the ipsilateral jugular foramen (JF) was normal-sized as displayed on computer tomography (CT). Conversely, jugular hypoplasia was with ipsilateral stenotic JF and without serpentine collaterals. Conclusion JF morphology and venous collaterals may be deemed as surrogate identifiers to distinguish acquired unilateral IJVS from jugular hypoplasia.


Author(s):  
Mary Beth Wire ◽  
Soo Youn Jun ◽  
In-Jin Jang ◽  
Seung-Hwan Lee ◽  
Jun Gi Hwang ◽  
...  

Thirty-two healthy male subjects (8 per cohort) were randomized 6:2 to active:placebo. LSVT-1701, an anti-staphylococcal lysin, was administered intravenously as a 6 mg/kg single dose and as 1.5, 3, and 4.5 mg/kg twice daily for 4 days. LSVT-1701 exposure increased in a greater than dose proportional manner and did not accumulate. Treatment-emergent adverse events (TEAEs) were predominantly of mild intensity. The most common TEAEs were chills, pyrexia, headache, infusion site events, cough, rhinorrhea, and increases in C-reactive protein.


Cosmetics ◽  
2022 ◽  
Vol 9 (1) ◽  
pp. 9
Author(s):  
Ana Lucía Morocho-Jácome ◽  
Bruna Bertoloni dos Santos ◽  
João Carlos Monteiro de Carvalho ◽  
Tânia Santos de Almeida ◽  
Patrícia Rijo ◽  
...  

“Vegan” and “sustainable” characteristics are strong claim trends behind the development of innovative skincare, fragrances, and makeup products. This created a need in the market for compliant ingredients. To date, there have been no records evidencing the use of the microalgae Neochloris oleoabundans (NA) in dermocosmetics. Therefore, we studied the applicability of such a natural compound in this context. NA was cultivated, and the scavenging activity (SA) of the NA extracts was evaluated. The highest SA was from the aqueous extract (54.8% ± 2.1%), being higher than that of the positive control. Two hydrogels were prepared with 1.0% ammonium acryloyldimethyltaurate/VP copolymer: (1) control gel; and (2) gel with a 1.0% NA aqueous extract. In vivo experiments were performed in healthy male and female volunteers with skin phototypes of II–IV. The stratum corneum (SC) hydration and the transepidermal water loss (TEWL) were measured in the forearm of participants to determine their biocompatibility. This parameter was determined by skin bioengineering measurements, confirming that SC hydration and TEWL were not affected by the samples. The laser Doppler measurements results showed a delayed erythema onset in the sites, where the NA hydrogel was applied. The results confirmed the biocompatibility and the anti-inflammatory activity of an innovative ingredient derived from microalgae suitable for a natural and vegan lifestyle.


2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Chao-Fang Bai ◽  
Guang-Hui Shen ◽  
Ying Yang ◽  
Ke Yang ◽  
Melvin R Hayden ◽  
...  

Abstract Background Subacute thyroiditis (SAT) is rarely diagnosed in pregnant women, and only 7 cases have been reported to date. Thyroid dysfunction, especially hyperthyroidism, during pregnancy has been associated with both maternal and neonatal complications. Thus, the early diagnosis and treatment of SAT during pregnancy may be beneficial. We present a case report and literature review to complement the diagnostic evaluation and management of SAT during pregnancy. Case presentation A 27-year-old woman presented in gestational week 17 of her first pregnancy and had a negative prior medical history. She presented to the Endocrinology Department complaining of neck pain for one month that had intensified in the last five days. Physical examination revealed a diffusely enlarged thyroid gland that was firm and tender on palpation. The patient also had an elevated temperature and heart rate. The increasing and long-lasting pain coupled with a decreased level of thyroid-stimulating hormone indicated hyperthyroidism. Ultrasound findings were indicative of SAT. Importantly, the pain was so severe that 10 mg of oral prednisone per day was administered in gestational week 18, which was increased to 15 mg/d after 10 days that was discontinued in week 28. Levothyroxine was started in gestational week 24 and administered throughout the pregnancy. The patient responded well to the treatments, and her neck pain disappeared in gestational week 21. She gave birth to a healthy male in gestational week 41. Conclusion SAT can be diagnosed and effectively managed during pregnancy, thus benefiting mothers and infants.


2022 ◽  
Vol 2022 ◽  
pp. 1-7
Author(s):  
Qian-nan Guo ◽  
Jing Wang ◽  
Hong-yan Liu ◽  
Dong Wu ◽  
Shi-xiu Liao

Around the whole world, smoking is considered harmful to human health, such as increasing the risk of cardiovascular disease (CVD, such as coronary heart disease and stroke) and lung cancer. The purpose of this study was to explore whether nicotine, the main component of tobacco, has adverse effects on heart rate variability (HRV) in adolescents, so as to remind adolescents not to smoke and not to take pleasure in abusing nicotine. In this study, 40 male and 40 female young healthy nonsmoking subjects were selected to analyze the changes of HRV after taking 4 mg nicotine orally. We found that nicotine reduced HRV in young healthy male and female subjects, and there was no gender difference in this effect ( P > 0.05 ). In conclusion, smoking is harmful to the cardiac system of young people, especially when nicotine content ≥4 mg dosage.


2022 ◽  
Vol 15 (01) ◽  
pp. 26-35
Author(s):  
Grace Umahi-Ottah ◽  
Babatunde Ishola Gabriel Adejumo ◽  
Elvis Osamede Godwins ◽  
Uchechukwu Dimkpa ◽  
Simon Uzor ◽  
...  

2022 ◽  
pp. 102662
Author(s):  
M. Dreßen ◽  
T. Luzius ◽  
H. Lahm ◽  
I. Neb ◽  
S.A. Doppler ◽  
...  

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