Structure−Activity Relationships in a Series of 2(1H)-Quinolones Bearing Different Acidic Function in the 3-Position:  6,7-Dichloro-2(1H)-oxoquinoline-3-phosphonic Acid, a New Potent and Selective AMPA/Kainate Antagonist with Neuroprotective Properties

1996 ◽  
Vol 39 (1) ◽  
pp. 197-206 ◽  
Author(s):  
Patrice Desos ◽  
Jean M. Lepagnol ◽  
Philippe Morain ◽  
Pierre Lestage ◽  
Alex A. Cordi
Keyword(s):  
Phosphonic Acid ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Acidic Function

scholarly journals Chemical Structure-Activity Relationships: Peroxisome Proliferation and Lipid Regulation in Rats

1992 ◽  
Vol 11 (3) ◽  
pp. 353-361 ◽  
Author(s):  
Edward J. Mcguire ◽  
Robert H. Gray ◽  
Felix A. De La Iglesia
Keyword(s):  
Plasma Cholesterol ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Peroxisome Proliferation ◽  
Structure Activity Relationships ◽  
Hypolipidemic Agents ◽  
Cholesterol Levels ◽  
Structure Activity ◽  
Plasma High Density ◽  
Acidic Function

Studies described here address structure-activity relationships of novel hypolipidemic agents that induce peroxisome proliferation. Male rats were given equivalent doses of three well-studied fibrates, fibrate amides, and structurally dissimilar agents. Aryloxyalkanoic acids, amide analogs, and thio, benzimidazole, phenylpiperazine, and oxazole derivatives induced peroxisome proliferation and decreased plasma cholesterol and triglyceride levels. These compounds contain an acidic function or appear to be readily metabolized to a derivative with an acidic function. Substitution of this substituent with an adamantyloxy eliminated peroxisome proliferation and induced contrasting effects on the lipid profile, substantially increasing triglycerides. A direct correlation was established between hepatocellular peroxisome proliferation and plasma high-density lipoprotein (HDD-cholesterol levels.

Structure-Activity Relationships of MDMA-Like Substances

1989 ◽  
Author(s):  
David E. Nichols ◽  
◽  
Robert Oberlender
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity

Structure-Activity Relationships in Cannabinoids: An Overview

1987 ◽  
Author(s):  
Raj K. Razdan ◽  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity

Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
Q Do ◽  
H Doan Thi Mai ◽  
T Gaslonde ◽  
B Pfeiffer ◽  
S Léonce ◽  
...  
Keyword(s):  
Pyran Ring ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure activity-relationships of P-Glycoprotein modulation using a small library of macrocyclic lathyrane diterpenes

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Reis ◽  
RJ Ferreira ◽  
MMM Santos ◽  
DJVA dos Santos ◽  
J Molnár ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
P Glycoprotein
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