scholarly journals Unwinding Dynamics of a Helically Wrapped Polymer

2014 ◽  
Vol 47 (14) ◽  
pp. 4840-4846 ◽  
Author(s):  
J.-C. Walter ◽  
M. Baiesi ◽  
E. Carlon ◽  
H. Schiessel
Keyword(s):  
Unwinding Dynamics

scholarly journals DNA-Unwinding Dynamics of Escherichia coli UvrD Lacking the C-Terminal 40 Amino Acids

2020 ◽  
Vol 118 (7) ◽  
pp. 1634-1648
Author(s):  
Hiroaki Yokota
Keyword(s):  
Escherichia Coli ◽  
Amino Acids ◽  
Dna Unwinding ◽  
Unwinding Dynamics

scholarly journals Active DNA unwinding dynamics during processive DNA replication

2012 ◽  
Vol 109 (21) ◽  
pp. 8115-8120 ◽  
Author(s):  
J. A. Morin ◽  
F. J. Cao ◽  
J. M. Lazaro ◽  
J. R. Arias-Gonzalez ◽  
J. M. Valpuesta ◽  
...  
Keyword(s):  
Dna Replication ◽  
Dna Unwinding ◽  
Unwinding Dynamics

scholarly journals Unwinding dynamics of double-stranded polymers

2010 ◽  
Vol 133 (15) ◽  
pp. 154907 ◽  
Author(s):  
M. Baiesi ◽  
G. T. Barkema ◽  
E. Carlon ◽  
D. Panja
Keyword(s):  
Unwinding Dynamics

scholarly journals MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jiaquan Liu ◽  
Ryanggeun Lee ◽  
Brooke M. Britton ◽  
James A. London ◽  
Keunsang Yang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Mismatch Repair ◽  
Single Molecule ◽  
Single Stranded Dna ◽  
Mismatched Dna ◽  
Sliding Clamps ◽  
Unwinding Dynamics ◽  
Exonuclease Digestion

AbstractA shared paradigm of mismatch repair (MMR) across biology depicts extensive exonuclease-driven strand-specific excision that begins at a distant single-stranded DNA (ssDNA) break and proceeds back past the mismatched nucleotides. Historical reconstitution studies concluded that Escherichia coli (Ec) MMR employed EcMutS, EcMutL, EcMutH, EcUvrD, EcSSB and one of four ssDNA exonucleases to accomplish excision. Recent single-molecule images demonstrated that EcMutS and EcMutL formed cascading sliding clamps on a mismatched DNA that together assisted EcMutH in introducing ssDNA breaks at distant newly replicated GATC sites. Here we visualize the complete strand-specific excision process and find that long-lived EcMutL sliding clamps capture EcUvrD helicase near the ssDNA break, significantly increasing its unwinding processivity. EcSSB modulates the EcMutL–EcUvrD unwinding dynamics, which is rarely accompanied by extensive ssDNA exonuclease digestion. Together these observations are consistent with an exonuclease-independent MMR strand excision mechanism that relies on EcMutL–EcUvrD helicase-driven displacement of ssDNA segments between adjacent EcMutH–GATC incisions.

scholarly journals Dna Unwinding Dynamics of a Processive DNA Polymerase

2011 ◽  
Vol 100 (3) ◽  
pp. 239a
Author(s):  
Borja Ibarra ◽  
Jose Morin ◽  
Francisco Cao ◽  
Margarita Salas ◽  
Jose M. Valpuesta ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Dna Unwinding ◽  
Unwinding Dynamics

Supercoiled pseudocircular domains in single twisted DNAs under tension. Elastic constants and unwinding dynamics in complexes with Topo I

Biopolymers ◽  
2013 ◽  
pp. n/a-n/a
Author(s):  
J. Michael Schurr ◽  
Bryant S. Fujimoto
Keyword(s):  
Elastic Constants ◽  
Unwinding Dynamics

scholarly journals DNA-Unwinding Dynamics of Escherichia Coli UvrD Lacking the C-Terminal 40 Amino Acids

2021 ◽  
Vol 120 (3) ◽  
pp. 35a
Author(s):  
Hiroaki Yokota
Keyword(s):  
Escherichia Coli ◽  
Amino Acids ◽  
Dna Unwinding ◽  
Unwinding Dynamics
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