Diarylheptanoids and Flavonoids from Viscum album Inhibit LPS-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells

2013 ◽  
Vol 76 (4) ◽  
pp. 495-502 ◽  
Author(s):  
Nguyen X. Nhiem ◽  
Phan V. Kiem ◽  
Chau V. Minh ◽  
Nanyoung Kim ◽  
SeonJu Park ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Inflammatory Cytokines ◽  
Viscum Album ◽  
Pro Inflammatory Cytokines

scholarly journals Bioactive Compounds from Polygala tenuifolia and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Pro-inflammatory Cytokine Production in Bone Marrow-Derived Dendritic Cells

Plants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1240
Author(s):  
Le Ba Vinh ◽  
Myungsook Heo ◽  
Nguyen Viet Phong ◽  
Irshad Ali ◽  
Young Sang Koh ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Inflammatory Cytokines ◽  
2D Nmr ◽  
Inhibitory Effects ◽  
Triterpenoid Saponins ◽  
Traditional Chinese Herbal Medicine ◽  
Polygala Tenuifolia ◽  
Anti Inflammatory ◽  
Pro Inflammatory Cytokines

The roots of Polygala tenuifolia Wild (Polygalaceae), which is among the most important components of traditional Chinese herbal medicine, have been widely used for over 1000 years to treat a variety of diseases. In the current investigation of secondary metabolites with anti-inflammatory properties from Korean medicinal plants, a phytochemical constituent study led to the isolation of 15 compounds (1–15) from the roots of P. tenuifolia via a combination of chromatographic methods. Their structures were determined by means of spectroscopic data such as nuclear magnetic resonance (NMR), 1D- and 2D-NMR, and liquid chromatography-mass spectrometry (LC-MS). As the obtained results, the isolated compounds were divided into two groups—phenolic glycosides (1–9) and triterpenoid saponins (10–15). The anti-inflammatory effects of crude extracts, fractions, and isolated compounds were investigated on the production of the pro-inflammatory cytokines interleukin (IL)-12 p40, IL-6, and tumour necrosis factor-α in lipopolysaccharide-stimulated bone marrow-derived dendritic cells. The IC50 values, ranging from 0.08 ± 0.01 to 21.05 ± 0.40 μM, indicated potent inhibitory effects of the isolated compounds on the production of all three pro-inflammatory cytokines. In particular, compounds 3–12, 14, and 15 showed promising anti-inflammatory activity. These results suggest that phenolic and triterpenoid saponins from P. tenuifolia may be excellent anti-inflammatory agents.

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