Stereoselective Synthesis of 2,6-cis- and 2,6-trans-Piperidines through Organocatalytic Aza-Michael Reactions: A Facile Synthesis of (+)-Myrtine and (−)-Epimyrtine
A series of newly prepared 3-((2,2,2-trifluoroethyl)amino)indolin-2-ones for the facile synthesis of chiral 3,2′-spirooxindole γ-lactam products containing trifluoroethyl groups have been developed.