Steric Bulkiness-Dependent Structural Diversity in Nickel(II) Complexes of N-Heterocyclic Carbenes: Synthesis and Structural Characterization of Tetra-, Penta-, and Hexacoordinate Nickel Complexes

2009 ◽  
Vol 28 (5) ◽  
pp. 1336-1349 ◽  
Author(s):  
Xiaoming Zhang ◽  
Bin Liu ◽  
Ailing Liu ◽  
Weilong Xie ◽  
Wanzhi Chen
Keyword(s):  
Structural Characterization ◽  
Nickel Complexes ◽  
Structural Diversity ◽  
Heterocyclic Carbenes

Synthesis and Structural Characterization of Tin Analogues ofN-Heterocyclic Carbenes

2008 ◽  
Vol 47 (23) ◽  
pp. 11367-11375 ◽  
Author(s):  
Stephen M. Mansell ◽  
Christopher A. Russell ◽  
Duncan F. Wass
Keyword(s):  
Structural Characterization ◽  
Heterocyclic Carbenes

scholarly journals Kinetic and Structural Characterization of the First B3 Metallo-β-Lactamase with an Active Site Glutamic Acid

2021 ◽  
Author(s):  
Liam A. Wilson ◽  
Esmée G. Knaven ◽  
Marc T. Morris ◽  
Marcelo Monteiro Pedroso ◽  
Christopher J. Schofield ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Structural Characterization ◽  
Active Site ◽  
Structural Diversity ◽  
Kinetic Properties ◽  
Design Studies ◽  
Degrading Bacterium ◽  
Active Site Motif ◽  
Wide Range

The structural diversity in metallo-β-lactamases (MBLs), especially in the vicinity of the active site, has been a major hurdle in the development of clinically effective inhibitors. Representatives from three variants of the B3 MBL subclass, containing either the canonical HHH/DHH active site motif (present in the majority of MBLs in this subclass) or the QHH/DHH (B3-Q) or HRH/DQK (B3-RQK) variations were reported previously. Here, we describe the structure and kinetic properties of the first example (SIE-1) of a fourth variant containing the EHH/DHH active site motif (B3-E). SIE-1 was identified in the hexachlorocyclohexane-degrading bacterium Sphingobium indicum , and kinetic analyses demonstrate that although it is active against a wide range of antibiotics its efficiency is lower than that of other B3 MBLs, but with improved efficiency towards cephalosporins relative to other β-lactam substrates. The overall fold of SIE-1 is characteristic of the MBLs; the notable variation is observed in the Zn1 site due to the replacement of the canonical His116 by a glutamate. The unusual preference of SIE-1 for cephalosporins and its occurrence in a widespread environmental organism suggests scope for increased MBL-mediated β-lactam resistance. It is thus relevant to include SIE-1 into MBL inhibitor design studies to widen the therapeutic scope of much needed anti-resistance drugs.

Structural characterization of the first linearly arranged Ag3 complexes supported by naphthyridine-functionalized N-heterocyclic carbenes

2008 ◽  
Vol 11 (4) ◽  
pp. 404-408 ◽  
Author(s):  
Jiansheng Ye ◽  
Shouwen Jin ◽  
Wanzhi Chen ◽  
Huayu Qiu
Keyword(s):  
Structural Characterization ◽  
Heterocyclic Carbenes

Synthesis and Structural Characterization of Nickel Complexes Possessing P-Stereogenic Pincer Scaffolds and Their Application in Asymmetric Aza-Michael Reactions

2015 ◽  
Vol 34 (7) ◽  
pp. 1228-1237 ◽  
Author(s):  
Zehua Yang ◽  
Delong Liu ◽  
Yangang Liu ◽  
Masashi Sugiya ◽  
Tsuneo Imamoto ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Nickel Complexes ◽  
Michael Reactions

ChemInform Abstract: Synthesis and Structural Characterization of Stable Pyridine- and Phosphine-Functionalized N-Heterocyclic Carbenes.

ChemInform ◽  
2010 ◽  
Vol 33 (28) ◽  
pp. no-no
Author(s):  
Andreas A. Danopoulos ◽  
Scott Winston ◽  
Thomas Gelbrich ◽  
Michael B. Hursthouse ◽  
Robert P. Tooze
Keyword(s):  
Structural Characterization ◽  
Heterocyclic Carbenes

scholarly journals Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience

2017 ◽  
Vol 13 ◽  
pp. 1145-1167 ◽  
Author(s):  
Serge Pérez ◽  
Daniele de Sanctis
Keyword(s):  
Synchrotron Radiation ◽  
Structural Characterization ◽  
Crystalline State ◽  
Structural Diversity ◽  
Interacting Proteins ◽  
X Ray ◽  
Wide Range ◽  
Kinetics Of

Synchrotron radiation is the most versatile way to explore biological materials in different states: monocrystalline, polycrystalline, solution, colloids and multiscale architectures. Steady improvements in instrumentation have made synchrotrons the most flexible intense X-ray source. The wide range of applications of synchrotron radiation is commensurate with the structural diversity and complexity of the molecules and macromolecules that form the collection of substrates investigated by glycoscience. The present review illustrates how synchrotron-based experiments have contributed to our understanding in the field of structural glycobiology. Structural characterization of protein–carbohydrate interactions of the families of most glycan-interacting proteins (including glycosyl transferases and hydrolases, lectins, antibodies and GAG-binding proteins) are presented. Examples concerned with glycolipids and colloids are also covered as well as some dealing with the structures and multiscale architectures of polysaccharides. Insights into the kinetics of catalytic events observed in the crystalline state are also presented as well as some aspects of structure determination of protein in solution.

Synthesis and Structural Characterization of Novel Oxorhenium(V) Complexes Containing N-Heterocyclic Carbenes

2004 ◽  
Vol 2004 (16) ◽  
pp. 3305-3309 ◽  
Author(s):  
Beatriz Royo ◽  
Eberhardt Herdtweck ◽  
Carlos C. Romão
Keyword(s):  
Structural Characterization ◽  
Heterocyclic Carbenes

New synthesis and structural characterization of O-aryldithiophosphato and O-alkyldithiophosphato nickel complexes with diphosphine ligands

Polyhedron ◽  
2014 ◽  
Vol 67 ◽  
pp. 490-494 ◽  
Author(s):  
Yu-Long Li ◽  
Bin Xie ◽  
Li-Ke Zou ◽  
Xiao Lin ◽  
Yi Yang ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Nickel Complexes ◽  
Diphosphine Ligands ◽  
New Synthesis
Sign in / Sign up

Export Citation Format

Share Document