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Many catalysts were tested in asymmetric Michael additions in order to synthesize
enantioenriched products. One of the most common reaction types among the Michael
reactions is the conjugated addition of malonates to enones making it possible to investigate
the structure–activity relationship of the catalysts. The most commonly used Michael
acceptors are chalcone, substituted chalcones, chalcone derivatives, cyclic enones,
while typical donors may be dimethyl, diethyl, dipropyl, diisopropyl, dibutyl, di-tert-butyl
and dibenzyl malonates. This review summarizes the most important enantioselective
catalysts applied in these types of reactions.
Discovery and optimization of enantioselective catalysts through chemoinformatics
