Inflammatory Breast Cancer Survival: The Role of Obesity and Menopausal Status at Diagnosis

2000 ◽  
Vol 64 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Shine Chang ◽  
Julie R. Alderfer ◽  
Lina Asmar ◽  
Aman U. Buzdar
Keyword(s):  
Breast Cancer ◽  
Inflammatory Breast Cancer ◽  
Cancer Survival ◽  
Menopausal Status ◽  
Breast Cancer Survival

scholarly journals SYK Allelic Loss and the Role of Syk-Regulated Genes in Breast Cancer Survival

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87610 ◽  
Author(s):  
Jan Blancato ◽  
Ashley Graves ◽  
Banafsheh Rashidi ◽  
Maria Moroni ◽  
Leopold Tchobe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survival ◽  
Breast Cancer Survival ◽  
Allelic Loss

scholarly journals Androgen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Kate M Peters ◽  
Stacey L Edwards ◽  
Shalima S Nair ◽  
Juliet D French ◽  
Peter J Bailey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Cancer Survival ◽  
Breast Cancer Survival ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Epigenetic Events

scholarly journals Research-based PAM50 signature and long-term breast cancer survival

2019 ◽  
Vol 179 (1) ◽  
pp. 197-206 ◽  
Author(s):  
Minya Pu ◽  
Karen Messer ◽  
Sherri R. Davies ◽  
Tammi L. Vickery ◽  
Emily Pittman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Stratification ◽  
Cancer Survival ◽  
Assessment Tool ◽  
Menopausal Status ◽  
Postmenopausal Breast Cancer ◽  
Breast Cancer Survival ◽  
Gene Signatures ◽  
Hypoxia Signature

Abstract Purpose Multi-gene signatures provide biological insight and risk stratification in breast cancer. Intrinsic molecular subtypes defined by mRNA expression of 50 genes (PAM50) are prognostic in hormone-receptor positive postmenopausal breast cancer. Yet, for 25–40% in the PAM50 intermediate risk group, long-term risk remains uncertain. Our study aimed to (i) test the long-term prognostic value of the PAM50 signature in pre- and post-menopausal breast cancer; (ii) investigate if the PAM50 model could be improved by addition of other mRNAs implicated in oncogenesis. Methods We used archived FFPE samples from 1723 breast cancer survivors; high quality reads were obtained on 1253 samples. Transcript expression was quantified using a custom codeset with probes for > 100 targets. Cox models assessed gene signatures for breast cancer relapse and survival. Results Over 15 + years of follow-up, PAM50 subtypes were (P < 0.01) associated with breast cancer outcomes after accounting for tumor stage, grade and age at diagnosis. Results did not differ by menopausal status at diagnosis. Women with Luminal B (versus Luminal A) subtype had a > 60% higher hazard. Addition of a 13-gene hypoxia signature improved prognostication with > 40% higher hazard in the highest vs lowest hypoxia tertiles. Conclusions PAM50 intrinsic subtypes were independently prognostic for long-term breast cancer survival, irrespective of menopausal status. Addition of hypoxia signatures improved risk prediction. If replicated, incorporating the 13-gene hypoxia signature into the existing PAM50 risk assessment tool, may refine risk stratification and further clarify treatment for breast cancer.

479: The role of Breast Cancer Associated gene 2 in EGFR endocytosis, downregulation and breast cancer survival

2014 ◽  
Vol 50 ◽  
pp. S115
Author(s):  
J. Wymant ◽  
S. Hiscox ◽  
A. Westwell ◽  
S. Urbé ◽  
M. Clague ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survival ◽  
Breast Cancer Survival

scholarly journals Role of Detection Method in Predicting Breast Cancer Survival: Analysis of Randomized Screening Trials

2005 ◽  
Vol 97 (16) ◽  
pp. 1195-1203 ◽  
Author(s):  
Yu Shen ◽  
Ying Yang ◽  
Lurdes Y. T. Inoue ◽  
Mark F. Munsell ◽  
Anthony B. Miller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Survival Analysis ◽  
Cancer Survival ◽  
Detection Method ◽  
Breast Cancer Survival ◽  
Screening Trials

scholarly journals Inflammatory and non-inflammatory breast cancer survival by socioeconomic position in the Surveillance, Epidemiology, and End Results database, 1990–2008

2012 ◽  
Vol 134 (3) ◽  
pp. 1257-1268 ◽  
Author(s):  
Jennifer A. Schlichting ◽  
Amr S. Soliman ◽  
Catherine Schairer ◽  
David Schottenfeld ◽  
Sofia D. Merajver
Keyword(s):  
Breast Cancer ◽  
Inflammatory Breast Cancer ◽  
Socioeconomic Position ◽  
Cancer Survival ◽  
Breast Cancer Survival ◽  
End Results
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