Two synaptic vesicle pools, vesicle recruitment and replenishment of pools at the Drosophila neuromuscular junction

2003 ◽  
Vol 32 (5-8) ◽  
pp. 551-565 ◽  
Author(s):  
Hiroshi Kuromi ◽  
Yoshi Kidokoro
Keyword(s):  
Neuromuscular Junction ◽  
Synaptic Vesicle ◽  
Vesicle Pools

scholarly journals Synaptic Vesicle Pools at the Frog Neuromuscular Junction

Neuron ◽  
2003 ◽  
Vol 39 (3) ◽  
pp. 529-541 ◽  
Author(s):  
David A Richards ◽  
Cristina Guatimosim ◽  
Silvio O Rizzoli ◽  
William J Betz
Keyword(s):  
Neuromuscular Junction ◽  
Synaptic Vesicle ◽  
Frog Neuromuscular Junction ◽  
Vesicle Pools

scholarly journals Clathrin Dependence of Synaptic-Vesicle Formation at the Drosophila Neuromuscular Junction

2008 ◽  
Vol 18 (6) ◽  
pp. 401-409 ◽  
Author(s):  
Heather Heerssen ◽  
Richard D. Fetter ◽  
Graeme W. Davis
Keyword(s):  
Neuromuscular Junction ◽  
Synaptic Vesicle ◽  
Vesicle Formation

Spatial variability in release at the frog neuromuscular junction measured with FM1-43

1999 ◽  
Vol 77 (9) ◽  
pp. 672-678 ◽  
Author(s):  
L -G Wu ◽  
W J Betz
Keyword(s):  
Neuromuscular Junction ◽  
Spatial Variability ◽  
Synaptic Vesicle ◽  
Motor Nerve ◽  
Frog Neuromuscular Junction ◽  
Electron Microscopic ◽  
Electrical Nerve Stimulation ◽  
Large Vesicle ◽  
Fluorescence And Electron Microscopy ◽  
Alpha Bungarotoxin

We quantified the spatial variability in release properties at different synaptic vesicle clusters in frog motor nerve terminals, using a combination of fluorescence and electron microscopy. Individual synaptic vesicle clusters labeled with FM1-43 varied more than 10-fold in initial intensity (integrated FM1-43 fluorescence) and in absolute rate of dye loss during tetanic electrical nerve stimulation. Most of this variability arose because large vesicle clusters spanned more than one presynaptic active zone (inferred from postsynaptic acetylcholine receptor stripes labeled with rhodamine-conjugated alpha-bungarotoxin); when the rate of dye loss was normalized to the length of receptor stripe covered, variability from spot to spot was greatly reduced. In addition, electron microscopic measurements showed that large vesicle clusters (i.e., those spanning multiple active zones) were also thicker, and the increased depth of vesicles led to increased total spot fluorescence without a corresponding increase in the rate of dye loss during stimulation. These results did not reveal the presence of "hot zones" of secretory activity.Key words: synaptic transmission, exocytosis, synaptic vesicles, neuromuscular junction.

scholarly journals Regulation of synaptic vesicle recycling by calcineurin in different vesicle pools

2005 ◽  
Vol 51 (4) ◽  
pp. 435-443 ◽  
Author(s):  
Susumu Kumashiro ◽  
Yun-Fei Lu ◽  
Kazuhito Tomizawa ◽  
Masayuki Matsushita ◽  
Fan-Yan Wei ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Synaptic Vesicle Recycling ◽  
Vesicle Recycling ◽  
Vesicle Pools
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