Letter to Patrick Leahy, Lindsey Graham, Kay Granger, and Nita Lowey offering thanks for strong support of sustained funding levels for global HIV/AIDS programs

2013 ◽  
Keyword(s):  
Strong Support ◽  
Hiv Aids

Amyloid β-peptide and Alzheimer's disease

2014 ◽  
Vol 56 ◽  
pp. 99-110 ◽  
Author(s):  
David Allsop ◽  
Jennifer Mayes
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Senile Plaques ◽  
Strong Support ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Amyloid Cascade Hypothesis ◽  
Sequence Of Events ◽  
Aβ Amyloid ◽  
Amyloid Cascade

One of the hallmarks of AD (Alzheimer's disease) is the formation of senile plaques in the brain, which contain fibrils composed of Aβ (amyloid β-peptide). According to the ‘amyloid cascade’ hypothesis, the aggregation of Aβ initiates a sequence of events leading to the formation of neurofibrillary tangles, neurodegeneration, and on to the main symptom of dementia. However, emphasis has now shifted away from fibrillar forms of Aβ and towards smaller and more soluble ‘oligomers’ as the main culprit in AD. The present chapter commences with a brief introduction to the disease and its current treatment, and then focuses on the formation of Aβ from the APP (amyloid precursor protein), the genetics of early-onset AD, which has provided strong support for the amyloid cascade hypothesis, and then on the development of new drugs aimed at reducing the load of cerebral Aβ, which is still the main hope for providing a more effective treatment for AD in the future.

Pediatric HIV/AIDS: Issues and Strategies for Intervention

ASHA Leader ◽  
2002 ◽  
Vol 7 (4) ◽  
pp. 10-21 ◽  
Author(s):  
Elise Davis-McFarland
Keyword(s):  
Pediatric Hiv ◽  
Hiv Aids

CDC Study: Most New Cases of HIV, AIDS in Women Occur in Blacks

Ob Gyn News ◽  
2005 ◽  
Vol 40 (6) ◽  
pp. 13
Author(s):  
Sharon Worcester
Keyword(s):  
Hiv Aids

World Leaders Endorse HIV/AIDS-TB Screening

2008 ◽  
Vol 39 (8) ◽  
pp. 38
Author(s):  
JONATHAN GARDNER
Keyword(s):  
Hiv Aids
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