Synergism between Thymocytes and Bone Marrow Cells in a Graft versus Host Reaction

Nature ◽  
1970 ◽  
Vol 227 (5253) ◽  
pp. 71-72 ◽  
Author(s):  
JOHN BARCHILON ◽  
RICHARD K. GERSHON
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
Graft Versus Host ◽  
Marrow Cells

Graft-versus-host reaction-like phenomenon Induced by BCG in mice lethally irradiated and transferred with syngeneic bone marrow cells

1977 ◽  
Vol 29 (2) ◽  
pp. 312-321 ◽  
Author(s):  
Shizuko Muraoka ◽  
Kikuo Nomoto ◽  
Tsunenori Miyake ◽  
Yoshiro Imada ◽  
Kenji Takeya
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
Graft Versus Host ◽  
Marrow Cells

scholarly journals Hereditary Thymic Dysplasia: A Graft-Versus-Host Reaction Induced by Bone Marrow Cells with a Partial 4a Series Histoincompatibility

1969 ◽  
Vol 3 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Roberto Kretschmer ◽  
Michel Jeannet ◽  
Tullio R Mereu ◽  
Kaethe Kretschmer ◽  
Henry Winn ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
Graft Versus Host ◽  
Marrow Cells

Experimental Models for Prevention of Graft-versus-Host Reaction in Bone Marrow Transfusion

1978 ◽  
Vol 56 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Hisanori Nagino ◽  
Kikuo Nomoto ◽  
Ataru Kuroiwa ◽  
Sumio Miyazaki ◽  
Nagahide Goya ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Experimental Models ◽  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
Graft Versus Host

scholarly journals CONTRIBUTION OF A THYMIC HUMORAL FACTOR TO THE DEVELOPMENT OF AN IMMUNOLOGICALLY COMPETENT POPULATION FROM CELLS OF MOUSE BONE MARROW

1971 ◽  
Vol 134 (3) ◽  
pp. 786-800 ◽  
Author(s):  
Myra Small ◽  
Nathan Trainin
Keyword(s):  
Bone Marrow ◽  
Lymphoid Tissue ◽  
Host Response ◽  
Bone Marrow Cells ◽  
Immune Reactivity ◽  
Mouse Bone Marrow ◽  
Graft Versus Host ◽  
Peripheral Lymphoid Tissue ◽  
Marrow Cells

The hypothesis that cells located in mouse bone marrow can acquire immunological competence by a process that involves interaction with a noncellular component of the thymus was tested using an in vitro assay of graft-versus-host reactivity as a criterion of cell competence. When suspensions of C57BL bone marrow cells were incubated in thymus extract and injected into mice incapable of inducing a response in the graft-versus-host assay as a result of neonatal thymectomy, or adult thymectomy plus irradiation, or because of genetic similarity with the (C3H x C57BL)F1 tissue used for challenge in the assay, competent cells were recovered from the spleens of the injected mice. The reactive cells were shown to be of bone marrow origin since immune reactivity was related to the genetic makeup of the bone marrow cells rather than that of the intermediate recipients. A thymic factor was involved in the process leading to immune reactivity by these cells, as bone marrow cells incubated in xenogeneic or syngeneic thymic extracts induced a graft-versus-host response after passage through nonresponsive mice, whereas incubation of bone marrow cells in xenogeneic lymph node or spleen extracts or in culture medium only did not lead to subsequent reactivity. Participation of peripheral lymphoid tissue seemed essential in this process since bone marrow cells tested directly after exposure to thymic extract failed to induce a graft-versus-host response. C57BL bone marrow cells exposed to thymus extract and cultured together with fragments of (C3H x C57BL)F1 spleen tissue in vitro were competent to induce a graft-versus-host response; thus, these components would seem to be sufficient as well as necessary for the immunodifferentiation process leading to graft-versus-host activity. It is concluded that one step in the process by which bone marrow cells acquire competence vis-a-vis the graft-versus-host response depends upon a thymic agent that is noncellular and extractable, and that another stage in this process is under the influence of components found within the peripheral lymphoid tissue environment. It is suggested that differentiation of precursor cells to competence could occur by progressive development of the cells in separate compartments of the lymphoid system.

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