The 5-HT2
 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go
-related gene (hERG) potassium channels

Q Tang; Z-Q Li; W Li; J Guo; H-Y Sun; X-H Zhang; C-P Lau; H-F Tse; S Zhang; G-R Li

doi:10.1038/bjp.2008.261

The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go -related gene (hERG) potassium channels

British Journal of Pharmacology ◽

10.1038/bjp.2008.261 ◽

2008 ◽

Vol 155 (3) ◽

pp. 365-373 ◽

Cited By ~ 14

Author(s):

Q Tang ◽

Z-Q Li ◽

W Li ◽

J Guo ◽

H-Y Sun ◽

...

Keyword(s):

Potassium Channels ◽

Open Channel ◽

Channel Blocker ◽

Related Gene ◽

Open Channel Blocker

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Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K+ channel

Journal of Molecular and Cellular Cardiology ◽

10.1016/j.yjmcc.2003.10.017 ◽

2004 ◽

Vol 36 (1) ◽

pp. 151-160 ◽

Cited By ~ 41

Author(s):

Z Su

Keyword(s):

Open Channel ◽

Channel Blocker ◽

K Channel ◽

Related Gene ◽

Open Channel Blocker

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Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor

Neuroreport ◽

10.1097/01.wnr.0000246323.66438.94 ◽

2007 ◽

Vol 18 (1) ◽

pp. 45-50 ◽

Cited By ~ 12

Author(s):

Ana S. Vall??s ◽

Ingrid Garbus ◽

Francisco J. Barrantes

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Open Channel ◽

Channel Blocker ◽

Nicotinic Acetylcholine ◽

Open Channel Blocker

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Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation

Neuroscience ◽

10.1016/s0306-4522(98)00163-8 ◽

1998 ◽

Vol 86 (4) ◽

pp. 1121-1132 ◽

Cited By ~ 143

Author(s):

H.-S.V Chen ◽

Y.F Wang ◽

P.V Rayudu ◽

P Edgecomb ◽

J.C Neill ◽

...

Keyword(s):

Open Channel ◽

Channel Blocker ◽

Long Term Potentiation ◽

Maze Learning ◽

Cytoplasmic Vacuolation ◽

Term Potentiation ◽

Open Channel Blocker

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7-Methoxyderivative of tacrine is a ‘foot-in-the-door’ open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo

Neuropharmacology ◽

10.1016/j.neuropharm.2018.08.010 ◽

2018 ◽

Vol 140 ◽

pp. 217-232 ◽

Cited By ~ 6

Author(s):

Martina Kaniakova ◽

Lenka Kleteckova ◽

Katarina Lichnerova ◽

Kristina Holubova ◽

Kristyna Skrenkova ◽

...

Keyword(s):

Nmda Receptors ◽

Open Channel ◽

Channel Blocker ◽

Neuroprotective Activity ◽

Open Channel Blocker

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The action of pyrantel as an agonist and an open channel blocker at acetylcholine receptors in isolated Ascaris suum muscle vesicles

European Journal of Pharmacology ◽

10.1016/0014-2999(94)90784-6 ◽

1994 ◽

Vol 271 (2-3) ◽

pp. 273-282 ◽

Cited By ~ 32

Author(s):

Susan J. Robertson ◽

Anne J. Pennington ◽

A. Mark Evans ◽

Richard J. Martin

Keyword(s):

Acetylcholine Receptors ◽

Open Channel ◽

Channel Blocker ◽

Ascaris Suum ◽

Open Channel Blocker

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Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat

European Journal of Pharmacology ◽

10.1016/s0014-2999(99)00214-9 ◽

1999 ◽

Vol 375 (1-3) ◽

pp. 115-120 ◽

Cited By ~ 61

Author(s):

Philip E Stieg ◽

Sumeer Sathi ◽

Steven Warach ◽

Dean A Le ◽

Stuart A Lipton

Keyword(s):

Nmda Receptor ◽

Open Channel ◽

Channel Blocker ◽

Focal Ischemia ◽

Neonatal Rat ◽

Open Channel Blocker

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Sodium channel-blocking properties of flecainide, a class IC antiarrhythmic drug, in guinea-pig papillary muscles An open channel blocker or an inactivated channel blocker

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/bf00736059 ◽

1989 ◽

Vol 339 (4) ◽

pp. 441-447 ◽

Cited By ~ 13

Author(s):

Michio Kojima ◽

Takuyuki Hamamoto ◽

Takashi Ban

Keyword(s):

Guinea Pig ◽

Sodium Channel ◽

Antiarrhythmic Drug ◽

Open Channel ◽

Channel Blocker ◽

Papillary Muscles ◽

Channel Blocking ◽

Open Channel Blocker

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The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker

Neuron ◽

10.1016/0896-6273(91)90277-7 ◽

1991 ◽

Vol 7 (5) ◽

pp. 743-753 ◽

Cited By ~ 204

Author(s):

Susan D. Demo ◽

Gary Yellen

Keyword(s):

Open Channel ◽

Channel Blocker ◽

K Channel ◽

Open Channel Blocker

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Locating a Plausible Binding Site for an Open-Channel Blocker, GlyH-101, in the Pore of the Cystic Fibrosis Transmembrane Conductance Regulator

Molecular Pharmacology ◽

10.1124/mol.112.080267 ◽

2012 ◽

Vol 82 (6) ◽

pp. 1042-1055 ◽

Cited By ~ 27

Author(s):

Yohei Norimatsu ◽

Anthony Ivetac ◽

Christopher Alexander ◽

Nicolette O'Donnell ◽

Leah Frye ◽

...

Keyword(s):

Cystic Fibrosis ◽

Binding Site ◽

Open Channel ◽

Channel Blocker ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane ◽

Open Channel Blocker

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A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1

European Journal of Pharmacology ◽

10.1016/j.ejphar.2018.02.013 ◽

2018 ◽

Vol 824 ◽

pp. 99-107 ◽

Cited By ~ 2

Author(s):

Meikui Wu ◽

Makoto Takemoto ◽

Huan Luo ◽

Jian-Jun Xu ◽

Mei-Hong Lu ◽

...

Keyword(s):

Open Channel ◽

Channel Blocker ◽

Antitumor Agent ◽

Open Channel Blocker

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