Dose-Dependent Acute and Sustained Renal Effects of the Endothelin Receptor Antagonist Avosentan in Healthy Subjects

J Smolander; B Vogt; M Maillard; C Zweiacker; T Littke; T Hengelage; M Burnier

doi:10.1038/clpt.2009.15

Dose-Dependent Acute and Sustained Renal Effects of the Endothelin Receptor Antagonist Avosentan in Healthy Subjects

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2009.15 ◽

2009 ◽

Vol 85 (6) ◽

pp. 628-634 ◽

Cited By ~ 24

Author(s):

J Smolander ◽

B Vogt ◽

M Maillard ◽

C Zweiacker ◽

T Littke ◽

...

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Renal Effects ◽

Dose Dependent

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Pharmacokinetics and pharmacodynamics of tezosentan, an intravenous dual endothelin receptor antagonist, following chronic infusion in healthy subjects

British Journal of Clinical Pharmacology ◽

10.1046/j.1365-2125.2002.01158.x ◽

2002 ◽

Vol 53 (4) ◽

pp. 355-362 ◽

Cited By ~ 26

Author(s):

Jasper Dingemanse ◽

Martine Clozel ◽

Paul L. M. Van Giersbergen

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Chronic Infusion

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of macitentan, an endothelin receptor antagonist, in an ascending multiple-dose study in healthy subjects

The Journal of Clinical Pharmacology ◽

10.1002/jcph.152 ◽

2013 ◽

pp. n/a-n/a ◽

Cited By ~ 15

Author(s):

Patricia N. Sidharta ◽

Paul L. M. van Giersbergen ◽

Jasper Dingemanse

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Multiple Dose ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetics And Pharmacodynamics ◽

Multiple Dose Study ◽

Dose Study

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Investigation of mutual pharmacokinetic interactions between macitentan, a novel endothelin receptor antagonist, and sildenafil in healthy subjects

British Journal of Clinical Pharmacology ◽

10.1111/bcp.12447 ◽

2014 ◽

Vol 78 (5) ◽

pp. 1035-1042 ◽

Cited By ~ 14

Author(s):

Patricia N. Sidharta ◽

Paul L. M. van Giersbergen ◽

Michael Wolzt ◽

Jasper Dingemanse

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetic Interactions

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Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2043 ◽

2020 ◽

Author(s):

Pierre Gueneau de Mussy ◽

Patricia N. Sidharta ◽

Gregoire Wuerzner ◽

Marc P. Maillard ◽

Nicolas Guérard ◽

...

Keyword(s):

Body Weight ◽

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

High Sodium ◽

Fluid Homeostasis ◽

Sodium Diet ◽

High Sodium Diet

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Macitentan, a dual endothelin receptor antagonist for the treatment of pulmonary arterial hypertension, does not affect cardiac repolarization in healthy subjects

Pulmonary Pharmacology & Therapeutics ◽

10.1016/j.pupt.2014.04.007 ◽

2014 ◽

Vol 29 (1) ◽

pp. 41-48 ◽

Cited By ~ 5

Author(s):

Nicolas Lindegger ◽

Patricia N. Sidharta ◽

Kathrin Reseski ◽

Jasper Dingemanse

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Cardiac Repolarization ◽

Endothelin Receptor ◽

Pulmonary Arterial

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DOSE-DEPENDENT EFFICACY OF THERAPY WITH NONSELECTIVE ENDOTHELIN RECEPTOR ANTAGONIST BOSENTAN IN PATIENTS WITH IDIOPATHIC PULMONARY HYPERTENSION

Journal of Hypertension ◽

10.1097/00004872-201106001-00978 ◽

2011 ◽

Vol 29 ◽

pp. e338 ◽

Cited By ~ 1

Author(s):

O. Arkhipova ◽

E. Kobal ◽

N. Danilov ◽

T. Martynyuk ◽

L. Samoilenko ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Idiopathic Pulmonary Hypertension ◽

Dose Dependent

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Investigation of the Effects of Ketoconazole on the Pharmacokinetics of Macitentan, a Novel Dual Endothelin Receptor Antagonist, in Healthy Subjects

Clinical Pharmacokinetics ◽

10.1007/s40262-013-0063-8 ◽

2013 ◽

Vol 52 (8) ◽

pp. 685-692 ◽

Cited By ~ 31

Author(s):

Jacob Atsmon ◽

Jasper Dingemanse ◽

Dimitri Shaikevich ◽

Inna Volokhov ◽

Patricia N. Sidharta

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor

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Lack Of Clinically Relevant Pharmacokinetic Interactions Between The Dual Endothelin Receptor Antagonist Macitentan And Sildenafil In Healthy Subjects

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4802 ◽

2012 ◽

Cited By ~ 1

Author(s):

P N. Sidharta ◽

P L.M. van Giersbergen ◽

Michael Wolzt ◽

Jasper Dingemanse

Keyword(s):

Receptor Antagonist ◽

Healthy Subjects ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacokinetic Interactions

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Endothelin Receptor Antagonist

10.32388/54vclc ◽

2020 ◽

Author(s):

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor

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Faculty Opinions recommendation of Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13198963.14726480 ◽

2011 ◽

Author(s):

Luciana Mascia ◽

Ilaria Mastromauro

Keyword(s):

Subarachnoid Haemorrhage ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Aneurysmal Subarachnoid Haemorrhage ◽

Endothelin Receptor ◽

Surgical Clipping ◽

Phase 3 ◽

Double Blind ◽

Double Blind Placebo

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