scholarly journals Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex

2012 ◽  
Vol 31 (6) ◽  
pp. 1467-1479 ◽  
Author(s):  
Teresa Rivera ◽  
Cristina Ghenoiu ◽  
Miriam Rodríguez-Corsino ◽  
Satoru Mochida ◽  
Hironori Funabiki ◽  
...  
Keyword(s):  
Spindle Assembly ◽  
Chromosomal Passenger Complex ◽  
Assembly Pathway ◽  
Chromosomal Passenger

scholarly journals The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly

2011 ◽  
Vol 193 (1) ◽  
pp. 155-169 ◽  
Author(s):  
Lindsay Lewellyn ◽  
Ana Carvalho ◽  
Arshad Desai ◽  
Amy S. Maddox ◽  
Karen Oegema
Keyword(s):  
Contractile Ring ◽  
Chromosomal Passenger Complex ◽  
Ring Assembly ◽  
Assembly Pathway ◽  
Chromosomal Passenger ◽  
Spindle Midzone ◽  
Ring Constriction ◽  
Simultaneous Inhibition ◽  
Control Transformation ◽  
Equatorial Band

The chromosomal passenger complex (CPC) and centralspindlin are conserved cytokinesis regulators that localize to the spindle midzone, which forms between the separating chromosomes. Previous work placed the CPC and centralspindlin in a linear pathway that governs midzone formation. Using Caenorhabditis elegans embryos, we test whether there is a similar linear relationship between centralspindlin and the CPC in contractile ring constriction during cytokinesis. We show that simultaneous inhibition of the CPC kinase Aurora BAIR-2 and the centralspindlin component MKLP1ZEN-4 causes an additive constriction defect. Consistent with distinct roles for the proteins, inhibition of filamentous septin guanosine triphosphatases alleviates constriction defects in Aurora BAIR-2–inhibited embryos, whereas inhibition of Rac does so in MKLP1ZEN-4-inhibited embryos. Centralspindlin and the CPC are not required to enrich ring proteins at the cell equator but instead regulate formation of a compact mature ring. Therefore, in contrast to the linear midzone assembly pathway, centralspindlin and the CPC make independent contributions to control transformation of the sheet-like equatorial band into a ribbon-like contractile ring at the furrow tip.

scholarly journals The Borealin dimerization domain interacts with Sgo1 to drive Aurora B–mediated spindle assembly

2020 ◽  
Vol 31 (20) ◽  
pp. 2207-2218 ◽  
Author(s):  
Mary Kate Bonner ◽  
Julian Haase ◽  
Hayden Saunders ◽  
Hindol Gupta ◽  
Biyun Iris Li ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Spindle Assembly ◽  
Specific Role ◽  
Aurora B ◽  
Dimerization Domain ◽  
Chromosomal Passenger Complex ◽  
Chromosomal Passenger ◽  
Segregation Of Chromosomes

This study provides the molecular mechanism for the interaction of Sgo1 with the chromosomal passenger complex and explores the specific role of Sgo1 in regulating Aurora B functions that ensure the equal segregation of chromosomes.

scholarly journals The Chromosomal Passenger Complex Is Required for Chromatin-Induced Microtubule Stabilization and Spindle Assembly

Cell ◽  
2004 ◽  
Vol 118 (2) ◽  
pp. 187-202 ◽  
Author(s):  
Srinath C Sampath ◽  
Ryoma Ohi ◽  
Oliver Leismann ◽  
Adrian Salic ◽  
Andrei Pozniakovski ◽  
...  
Keyword(s):  
Spindle Assembly ◽  
Chromosomal Passenger Complex ◽  
Microtubule Stabilization ◽  
Chromosomal Passenger

scholarly journals Chromosome-directed oocyte spindle assembly depends HP1 and the Chromosomal Passenger Complex

2020 ◽  
Author(s):  
Lin-Ing Wang ◽  
Tyler DeFosse ◽  
Rachel A. Battaglia ◽  
Victoria F. Wagner ◽  
Kim S. McKim
Keyword(s):  
Homologous Chromosome ◽  
Spindle Assembly ◽  
Aurora B ◽  
Aurora B Kinase ◽  
Chromosomal Passenger Complex ◽  
Central Spindle ◽  
Bipolar Spindle ◽  
Chromosomal Passenger ◽  
Spindle Microtubules

AbstractThe chromosomes in the oocytes of many animals appear to promote bipolar spindle assembly. In Drosophila oocytes, spindle assembly requires the chromosomal passenger complex (CPC), which consists of INCENP, Borealin, Survivin and Aurora B. To determine what recruits the CPC to the chromosomes and its role in spindle assembly, we developed a strategy to manipulate the function and localization of INCENP, which is critical for recruiting the Aurora B kinase. We found that an interaction between Borealin and HP1 is crucial for the initial recruitment of the CPC to the chromosomes and is sufficient to build kinetochores and recruit spindle microtubules. We also found that HP1 moves from the chromosomes to the spindle microtubules along with the CPC, and based on this, propose a mechanism for how the CPC moves from the chromosomes to the microtubules. Within the central spindle, rather than at the centromeres, the CPC and HP1 are required for homologous chromosome bi-orientation.

scholarly journals The Chromosomal Passenger Complex Is Required for Meiotic Acentrosomal Spindle Assembly and Chromosome Biorientation

Genetics ◽  
2012 ◽  
Vol 192 (2) ◽  
pp. 417-429 ◽  
Author(s):  
Sarah J. Radford ◽  
Janet K. Jang ◽  
Kim S. McKim
Keyword(s):  
Spindle Assembly ◽  
Chromosomal Passenger Complex ◽  
Chromosomal Passenger

scholarly journals Dual Detection of Chromosomes and Microtubules by the Chromosomal Passenger Complex Drives Spindle Assembly

2010 ◽  
Vol 18 (6) ◽  
pp. 903-912 ◽  
Author(s):  
Boo Shan Tseng ◽  
Lei Tan ◽  
Tarun M. Kapoor ◽  
Hironori Funabiki
Keyword(s):  
Spindle Assembly ◽  
Chromosomal Passenger Complex ◽  
Chromosomal Passenger ◽  
Dual Detection
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