scholarly journals Single-cell heterogeneity in ductal carcinoma in situ of breast

2017 ◽  
Vol 31 (3) ◽  
pp. 406-417 ◽  
Author(s):  
Michael J Gerdes ◽  
Yesim Gökmen-Polar ◽  
Yunxia Sui ◽  
Alberto Santamaria Pang ◽  
Nicole LaPlante ◽  
...  
2021 ◽  
Author(s):  
Esther H. Lips ◽  
Tapsi Kumar ◽  
Anargyros Megalios ◽  
Lindy L. Visser ◽  
Michael Sheinman ◽  
...  

Pure ductal carcinoma in situ (DCIS) is being diagnosed more frequently through breast screening programmes and is associated with an increased risk of developing invasive breast cancer. We assessed the clonal relatedness of 143 cases of pure DCIS and their subsequent events using a combination of whole exome, targeted and copy number sequencing, supplemented by single cell analysis. Unexpectedly, 18% of all invasive events after DCIS were clonally unrelated to the primary DCIS. Single cell sequencing of selected pairs confirmed our findings. In contrast, synchronous DCIS and invasive disease (n=44) were almost always (93%) clonally related. This challenges the dogma that most invasive events after DCIS represent invasive transformation of the initial DCIS and suggests that DCIS could be an independent risk factor for developing invasive disease as well as a precursor lesion.


1999 ◽  
Vol 41 (6) ◽  
pp. 1225
Author(s):  
Eung Yeop Kim ◽  
Boo Kyung Han ◽  
Yeon Hyeon Choe ◽  
Seok Jin Nam ◽  
Young Hyeh Ko ◽  
...  

2019 ◽  
Author(s):  
Gemma M Wilson ◽  
Barbara J Guild ◽  
Christine L Clarke ◽  
Nirmala Pathmanathan ◽  
J Dinny Graham

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