Predictive role of optical coherence tomography angiography for exudation recurrence in patients with type 1 neovascular age-related macular degeneration treated with pro-re-nata protocol

Eye ◽  
2022 ◽  
Author(s):  
Mihyun Choi ◽  
Seong-Woo Kim ◽  
Cheolmin Yun ◽  
Jong-Hyun Oh ◽  
Jaeryung Oh
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Age Related ◽  
Predictive Role ◽  
Pro Re Nata

scholarly journals Optical coherence tomography angiography in exudative age-related macular degeneration: a predictive model for treatment decisions

2018 ◽  
Vol 103 (9) ◽  
pp. 1342-1346 ◽  
Author(s):  
Florence Coscas ◽  
Marco Lupidi ◽  
Jean François Boulet ◽  
Alexandre Sellam ◽  
Diogo Cabral ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Univariate Analysis ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Age Related ◽  
The Status ◽  
Predictive Role

AimsTo evaluate on optical coherence tomography angiography (OCT-A), the predictive role of different qualitative findings of choroidal neovascularisations (CNV) in assessing the status of exudative age-related macular degeneration (eAMD) and to develop a potential model to predict the CNV activity.MethodsRetrospective review of the multimodal imaging records of patients with eAMD obtained during treatment for type 1 or type 2 CNV. The qualitative analysis of CNVs on OCT angiograms assessed the presence or absence of tiny branching vessels, loops, peripheral anastomotic arcades and choriocapillaris hypointense halo. These findings were then correlated with those of structural OCT scans. A score forecast was built and validated.ResultsOne hundred and twenty-six eAMD eyes were enrolled in the study. Exudation was observed in 90 eyes (71%) on structural OCT. The qualitative OCT-A analysis revealed: tiny branching vessels in 82.5% of the cases, vascular loops in 81.7%, peripheral anastomotic arcades in 66.7% and choriocapillaris hypointense halo in 54.8%. In the univariate analysis, each OCT-A parameter showed a statistically significant correlation with exudation on structural OCT (p<0.001). The overall analysis demonstrated a sensitivity of 96.7% and a positive predictive value of 87.9%. In the multivariate analysis, a model with four criteria predicted an exudative lesion in 97.6% of cases and one with two criteria (tiny branching vessels and peripheral anastomotic arcades) in 71.2%.ConclusionsThe presence of tiny branching vessels and a peripheral anastomotic arcade appears to predict the lesion activity with a good accuracy and the model based on four criteria enables optimal decisions regarding retreatment in eAMD.

Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration

2015 ◽  
Vol 160 (4) ◽  
pp. 739-748.e2 ◽  
Author(s):  
Laura Kuehlewein ◽  
Mayank Bansal ◽  
Tamara L. Lenis ◽  
Nicholas A. Iafe ◽  
SriniVas R. Sadda ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Age Related

scholarly journals Role of Optical Coherence Tomography Angiography in the Diagnosis and Management of Wet Age-Related Macular Degeneration

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
F M Zaher ◽  
M G Metwally ◽  
B F Aziz ◽  
Y Z Abdelwadood
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Imaging Modality ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Diagnosis And Management ◽  
Age Related ◽  
Wet Amd

Abstract Background Neo-vascular age-related macular degeneration (nAMD) (an advanced form of macular degeneration) is the main cause of visual impairment in older adults related to AMD. WHO has estimated that approximately 8 million people will be affected by AMD by the year 2020. Optical coherence tomography angiography (OCTA) is a novel imaging modality that permits direct visualization of the retinal and choroidal vasculature in vivo. In OCTA, high-frequency and dense volumetric scanning are made to detect blood flow by analyzing the signal decorrelation between scans. Compared with stationary areas of the retina, the movement of erythrocytes within a vessel makes a decorrelated signal. Unlike traditional angiography, OCTA does not necessitate the use of exogenous dyes, so avoiding potential side effects, such as nausea or other more serious adverse events. However, the role of OCTA as a diagnostic tool has not been largely investigated. Particularly, very few clinical studies have assessed the accuracy of OCTA imaging for the diagnosis of nAMD. Aim of the Work To highlight the benefits of using OCT-A in the diagnosis and management of wet AMD and compare it with the conventional angiographic standard, fundus fluorescein angiography (FFA). Subjects and Methods An interventional prospective comparative study will be conducted on 40 eyes diagnosed with wet AMD. Optical coherence tomography angiography and FFA will be done for all eyes. Analysis of the data obtained from the OCT-A will be done and compared with the standard FFA. Conclusion AMD is the leading cause of vision loss. Early detection and treatment is required. AMD is diagnosed by fundus examination, FA, and OCTA. OCTA and FA imaging provide complementary information about pathological changes in chorioretinal diseases. OCTA is highly sensitive for identifying AMD, CNV, and CNV activity; however, it cannot fully replace FA in the diagnosis of AMD.

scholarly journals Comparison of optical coherence tomography angiography features in type 1 versus type 2 choroidal neovascular membranes secondary to age-related macular degeneration

2021 ◽  
Vol 10 (2) ◽  
pp. 25-31
Author(s):  
Yasin Sakir Goker ◽  
Gokhan Demir
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Dead Tree ◽  
Flow Area ◽  
Age Related

Background: Optical coherence tomography angiography (OCTA) is an advanced imaging modality that provides high resolution images at the level of different retinal layers. This study aime to evaluate choroidal neovascular membranes (CNVMs) secondary to age-related macular degeneration (AMD) quantitatively and qualitatively, according to their classification, morphological features, and flow areas, using OCTA. Methods: In this descriptive, comparative, cross-sectional study, CNVMs were divided into 2 groups according to their classification as type 1 or type 2 neovascularization. Mixed CNVMs were excluded from the study. The size (mm2) and the flow area (mm2) of the CNVMs were calculated via OCTA and the presence of the perivascular halo and loop anastomoses were analyzed. The morphological appearance of the CNVMs were classified as: medusa, sea-fan, lacy-wheel, glomerular, dead tree, and mature vascular networks. Results: Of the 85 eyes assessed for eligibility, 45 eyes of 34 individuals with CNVM were enrolled in this retrospective study. Twenty-eight eyes had type 1 and 17 eyes had type 2 CNVMs. The mean size and flow area were greater in type 1 than in type 2 CNVMs (mean ± standard deviation [SD], 6.69 ± 4.54 and 3.61 ± 3.56 mm2 versus 3.04 ± 1.98 and 1.77 ± 1.62 mm2; P = 0.044 and 0.046, respectively). Among the 22 eyes with type 1 CNVMs and the 9 eyes with type 2 CNVMs, 31 eyes had exudative membranes. Among the eyes with exudative CNVMs, 22 eyes had a perivascular halo and 22 eyes had loop anastomoses; this was significantly more than in the non-exudative eyes (P = 0.042 and 0.041, respectively). The lacy-wheel (38.7%) and dead tree (71.4%) patterns were the most frequent morphological appearance of the CNVMs in the exudative and non-exudative membranes, respectively. Conclusions: OCTA provides objective documantation about CNVMs. A perivascular dark halo around CNVMs could be a criterion to define exudative membranes activity. How to cite this article: Goker YS, Demir G. Comparison of optical coherence tomography angiography features in type 1 versus type 2 choroidal neovascular membranes secondary to age-related macular degeneration. Med Hypothesis Discov Innov Ophthalmol. 2021 Summer; 10(2): 25-31. https://doi.org/10.51329/mehdiophthal1423

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