Germline deletion of chromosome 2p16-21 associated with Lynch syndrome
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AbstractWe identified a Japanese patient with Lynch syndrome with a novel large germline deletion of chromosome 2p16-21, including the EPCAM, MSH2, and KCNK12 genes. The proband was a 46-year-old man with ascending colon cancer. The clinical significance of germline KCNK12 gene deletion, which encodes one of the subfamilies of two-pore-domain potassium channels, is still unknown.
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2015 ◽
Vol 76
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pp. 2749-2753
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2012 ◽
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pp. 185-191
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2018 ◽
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pp. 2096-2102
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