scholarly journals Long-term pulmonary function abnormalities and survival after allogeneic marrow transplantation

2004 ◽  
Vol 33 (5) ◽  
pp. 509-517 ◽  
Author(s):  
T K Marras ◽  
C K Chan ◽  
J H Lipton ◽  
H A Messner ◽  
J P Szalai ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Marrow Transplantation ◽  
Allogeneic Marrow Transplantation ◽  
Allogeneic Marrow

Allogeneic marrow transplantation for refractory Hodgkin's disease.

1989 ◽  
Vol 7 (8) ◽  
pp. 1039-1045 ◽  
Author(s):  
G L Phillips ◽  
D E Reece ◽  
M J Barnett ◽  
J M Connors ◽  
J W Fay ◽  
...  
Keyword(s):  
Patient Selection ◽  
Hodgkin's Disease ◽  
Marrow Transplantation ◽  
Lymphoproliferative Disorder ◽  
Hodgkin’S Disease ◽  
Substantial Toxicity ◽  
Allogeneic Marrow Transplantation ◽  
Allogeneic Marrow ◽  
Advanced Hodgkin’S Disease

Eight patients with refractory Hodgkin's disease received intensive combination chemotherapy conditioning with cyclophosphamide, carmustine (BCNU), and etoposide (VP 16-213), and allogeneic marrow transplants. All patients achieved complete responses. Three patients relapsed; two died of Hodgkin's disease and one of chronic graft-v-host disease (GVHD) and infection. In all, four patients died due to transplant-related toxicity. One patient developed a fatal B-cell lymphoproliferative disorder soon after transplantation, and died without evidence of Hodgkin's disease. One patient is alive and free of progression 29 months after transplantation. These data indicate that allogeneic marrow transplantation may be considered as therapy for selected patients with advanced Hodgkin's disease and, despite substantial toxicity, will occasionally result in long-term responses. Better patient selection would likely improve results.

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