Research Center
Recently Published Documents


TOTAL DOCUMENTS

6248
(FIVE YEARS 1653)

H-INDEX

60
(FIVE YEARS 10)

2022 ◽  
Vol 354 (11-12) ◽  
pp. 100-103
Author(s):  
I. V. Epifanova

Relevanсe. The novelty of our research lies in the fact that for the first time the allelopathic interaction of eastern galega seeds with a wide range of oilseeds is being studied. The aim of this work is to study the allelopathic effect in the initial stages of plant ontogenesis. The objectives of the study were to identify cultures with a positive and negative impact on the growth and development of sprouts of eastern galega. The objects of research were eastern galega Magister, false saffron Alexandrite, saperda mustard Lux, spring rape Tavrion, hemp Nadezhda, spring cress Iskra, white mustard Lucia, abyssinian colewort Polet, ethiopian niger seed Medea, oil radish Fiolina, damascene fennelflower Yalita, hybrid sunflower P63 LE 10 (XF 3020), winter camelina Baron, spring camelina Velez, oilseed flax Istok. The experiments were carried out in two layouts in 2019–2020 on the basis of a separate division of the Federal research center for fiber crops in the Penza region.Methods. The evaluation of allelopathic activity was carried out using a method that involves the germination of plant seeds, followed by the calculation of the percentage of germination. The number of seeds and seedlings at different stages of ontogenesis was determined along with measuring the length of the root, stem and leaf.Results. At the initial stages of ontogenesis, a weak negative allelopathic effect on the eastern galega is exerted by the abyssinian colewort Polet — the number of fullfledged seedlings was -6,1% to the control. A positive effect on the germination and development of galega seedlings is exerted by damascene fennelflower Yalita (+8,3% to control), ethiopian niger seed Medea (+8,1 to control), oilseed flax Istok (+6,4% to control). In general, the length of the galega seedling was at the level of control with damascene fennelflower and ethiopian niger seed is 3,27 and 3,24 cm (-0,40 and 0,43 cm respectively). A significant decrease is observed in the variants with oilseed flax, spring camelina, winter camelina, spring rape, false saffron, sunflower, saperda mustard, white mustard, hemp, abyssinian colewort and spring cress — from 2,81 to 1,66 cm (-0,86–2,01 cm to control).


2022 ◽  
Vol 97 (4) ◽  
Author(s):  
David Thurfjell ◽  
Erika Willander

The demographical changes during the last decades have created a sit­uation where Sweden has become one of the most secular and one of the most multireligious countries at the same time. This situation stands in stark contrast to the country's modern history in which its population have been largely homogeneous, and its religious landscape almost completely dominated by state-church Lutheranism. The growth of Sweden's Muslim population is what has caused most debate. According to calculations made by the Pew Research Center, one fifth of the country's total population is likely to be Muslim by 2050. This change also has consequences for the former state church, which now finds that also Muslims take part in its activities. In this article we present and analyze a novel survey-investigation on Muslims who self-identify as members of the Church of Sweden. In our analysis we differentiate between Muslims and what we call post-Muslims. While the former of these categories refers to those who self-identify as Muslims, the latter refers to people who do not refer to themselves as Muslims but who come from a Muslim family. These categories are mirrored by the Christians and post-Christians, who are selected by equivalent criteria. We conclude that most Muslims and post-Muslims have no affiliation to organized religious communities in Sweden and that among those who do, Christian churches are as important as the Muslim congregations. Among the churches, the Church of Sweden is the one in which most Muslims and post-Muslims are members. The Muslim and post-Muslim members of this church, we find, differ from each other. The Muslims are mostly Swedish-born 50–65-year-old women. They do not take part in any religious activities, and they celebrate Christian, but not Muslim, holidays. In terms of beliefs, they believe in a life after death, but mostly not in God or hell. The post-Muslims are mostly 30–49-year-old men who have come relatively recently to Sweden from the Middle East. They take part in congregational activities and celebrate both Muslim and Christian holidays. They also largely believe in God, a life after death, and hell. In terms of representation, they feel represented, primarily, by Muslim communities.


2022 ◽  
Vol 20 (8) ◽  
pp. 3119
Author(s):  
O. V. Kopylova ◽  
A. I. Ershova ◽  
M. S. Pokrovskaya ◽  
A. N. Meshkov ◽  
I. A. Efimova ◽  
...  

Aim. To analyze the structure of clinical data, as well as the principles of collecting and storing related data of the biobank of the National Medical Research Center for Therapy and Preventive Medicine (hereinafter Biobank).Material and methods. The analysis was carried out using the documentation available in the Biobank, as well as the databases used in its work. The paper presents clinical data on biosamples available in the Biobank as of August 18, 2021.Results. At the time of analysis, the Biobank had 373547 samples collected from 54192 patients within 37 research projects. The article presents the analysis of data representation and quantitative assessment of the presence/absence of common diagnoses in clinical projects. Approaches to documenting clinical information associated with biological samples stored in the Biobank were assessed. The methods and tools used for standardization and automation of processes used in the Biobank were substantiated.Conclusion. The Biobank of the National Medical Research Center for Therapy and Preventive Medicine is the largest research biobank in Russia, which meets all modern international requirements and is one of the key structures that improve the research quality and intensify their conduct both within the one center and in cooperation with other biobanks and scientific institutions. The collection and systematic storage of clinical abstracts of biological samples is an integral and most important part of the Biobank’s work.


2022 ◽  
Vol 20 (8) ◽  
pp. 3043
Author(s):  
N. V. Gnennaya ◽  
S. V. Timofeeva ◽  
A. O. Sitkovskaya ◽  
I. A. Novikova ◽  
I. B. Lysenko ◽  
...  

Aim. To create a collection of samples of blood components of patients with multiple myeloma for potential fundamental and applied biomedical research.Material and methods. The material was collected according to the developed algorithm, including the collection of clinical information, biological material, sample preparation, quality control and storage in the biobank of the National Medical Research Center of Oncology.Results. As of August 2021, the cryostorage of the National Medical Research Center of Oncology biobank contains a collection of 175 samples of blood serum, plasma and mononuclear cell fraction of patients with multiple myeloma. Samples were obtained from 32 patients of both sexes, the mean age of which was 59,5±1,65 years. To create an electronic catalog, personal, clinical and laboratory data about patients were collected, after which each sample was assigned its own unique identification number. Written informed consent was obtained from all patients for the storage of their biomaterial in a biobank with possible subsequent use for scientific purposes. Freezing of the obtained samples was carried out in accordance with low-temperature storage protocol. The electronic catalog contains a wide range of systematized clinical and laboratory information on samples.Conclusion. The collection of multiple myeloma samples is a unique resource for potential research on its pathophysiology, the development of diagnostic biomarkers, and the search for targeted agents.


2022 ◽  
Vol 20 (8) ◽  
pp. 3027
Author(s):  
V. Yu. Tabakov

Biobanking is one of the most important elements of the modern infrastructure for biomedical research. Organization of a biobank on the basis of the N. P. Bochkov Medical Genetics Research Center provides a centralized infrastructure for preparing biomaterial for research. Biobank has the format of a research equipment sharing center and works with two types of unique biomaterials from patients with genetic diseases: blood/blood components and vital cells of various tissue origin. The storage facility of the Biobank is equipped with low-temperature (-80° C) and cryostorage (-196° C) systems. Identification and search of samples is carried out using a bar-coding system and is implemented through the information interface of the biobank, which is integrated into the general database of patients at the Medical Genetics Research Center. Information on biomaterial samples is presented in periodically updated catalogs on the page of equipment sharing center “Biobank”. Biobank collection is available to internal and external users.


Author(s):  
G Fikre ◽  
A Mensa

The experiment was conducted to evaluate the adaptability of newly released papaya varieties at Chano Mille research site of Arba Minch Agricultural Research Center during 2019-2020 cropping seasons. The three hermaphrodite papaya varieties namely; Braz-HS1, Koka-HM1 and Meki-HL1 were used for the study and laid-out in a Randomized Complete Block Design in three replications. Data on yield and yield components were collected and analyzed by using analysis of variance (ANOVA) through Statistical Analytics System software. The ANOVA results revealed that there were significant variations among papaya varieties for the studied parameters. Significantly, the highest number of fruits plant-1, number of leaves and fruit yield were obtained from Braz-HS1 papaya variety. The fruit yield of Braz-HS1 variety was 46% higher than that of Koka-HM1. In general, Braz-HS1 papaya variety performed (in terms of number of fruits and fruit yield) better than the rest two varieties. Thus, Braz-HS1 papaya variety could be recommended for the papaya growers in the study area and vicinity with similar agro-ecology. Int. J. Agril. Res. Innov. Tech. 11(2): 69-71, Dec 2021


Author(s):  
YD Nayak ◽  
AP Sahoo

The experiment was conducted to evaluate the adaptability of newly released papaya varieties at Chano Mille research site of Arba Minch Agricultural Research Center during 2019-2020 cropping seasons. The three hermaphrodite papaya varieties namely; Braz-HS1, Koka-HM1 and Meki-HL1 were used for the study and laid-out in a Randomized Complete Block Design in three replications. Data on yield and yield components were collected and analyzed by using analysis of variance (ANOVA) through Statistical Analytics System software. The ANOVA results revealed that there were significant variations among papaya varieties for the studied parameters. Significantly, the highest number of fruits plant-1, number of leaves and fruit yield were obtained from Braz-HS1 papaya variety. The fruit yield of Braz-HS1 variety was 46% higher than that of Koka-HM1. In general, Braz-HS1 papaya variety performed (in terms of number of fruits and fruit yield) better than the rest two varieties. Thus, Braz-HS1 papaya variety could be recommended for the papaya growers in the study area and vicinity with similar agro-ecology. Int. J. Agril. Res. Innov. Tech. 11(2): 72-75, Dec 2021


BMC Cancer ◽  
2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Naela Agha ◽  
Bader Alshamsan ◽  
Sharifa Al-Farsi ◽  
Heba Aly Ateya ◽  
Fahad A. Almugbel ◽  
...  

Abstract Purpose BRCA gene mutations (BRCAm) have an impact on patients’ characteristics and clinical outcomes of ovarian cancer (OC). The frequency and patterns of BRCAm vary among countries and ethnicities. There are limited data from Saudi Arabia (SA); thus, this study aims to determine the frequency, pattern, and impact on patient characteristics and outcomes of BRCAm OC compared to wild-type BRCA (BRCAw) in Saudi women. Methods This retrospective study evaluated women diagnosed with non-mucinous OC, fallopian tube, or peritoneal carcinoma who had BRCA status tested in an accredited lab between January 2016 and December 2017. The associations between various parameters and BRCAm were estimated using logistic regression. Statistical analysis performed with SPSS (Version 27). Result Sixty-one women with a median age of 52 at diagnosis were analyzed. Germline BRCA mutations were found in 41% of cases (25/61). The most common deleterious germline BRCA1 mutation was c.1140dupG (39%). Most women (72%) had no family history of cancers and 82% had advanced stage. Regardless of BRCA mutations, an optimal overall response rate (ORR) to first-line treatment has been achieved although most cases relapsed (84%) and the majority were platinum-sensitive relapse (85%). Higher ORR to subsequent lines and better survival were obtained in women with BRCA-mutation. Conclusion The prevalence of BRCAm of OC was higher in Saudi women compared to regional and most of the international figures. The better clinical outcomes of BRCAm women agreed with the reported evidence. Further studies on BRCA mutations of OC and genetic counseling are highly recommended. Trial registration Trial approved by the Institutional Review Board of King Faisal Specialist Hospital and Research Center (RAC # 2171137) and conducted at King Faisal Specialist Hospital and Research Center, PO Box 3354, Riyadh 11,211, Saudi Arabia.


2022 ◽  
pp. 16-19
Author(s):  
М. А. Bolokhonova ◽  
V. Yu. Panarina ◽  
E. V. Sharapova ◽  
S. N. Mikhailova ◽  
Т. Т. Valiev ◽  
...  

Gorlin-Golts syndrome is a genetic determined disease, characterized by multisystem features and associated with different malignancies, which are more aggressive with very unfavorable prognosis. By literature data this syndrome is a rare pathology. Observation and treatment of patients with Gorlin-Golts syndrome include syndromic correction of clinical presentations and detailed observation for early malignancies detection. In the current issue a survey of modern literature about Gorlin-Golts syndrome in children and clinical case of patient sent to Federal State Budgetary Institution» N. N. Blokhin National Medical Research Center of Oncology «of the Ministry of Health for malignancy diagnosis are presented. By global and own clinical experience about Gorlin-Golts syndrome it is necessary a genetic verification and make us perform a multidisciplinary control for such patient health with obligatory examination and observation of pediatric oncologist.


Sign in / Sign up

Export Citation Format

Share Document