The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation

2005 ◽  
Vol 3 (13) ◽  
pp. 2431 ◽  
Author(s):  
Ian Paterson ◽  
David Y.-K. Chen ◽  
Mark J. Coster ◽  
José L. Aceña ◽  
Jordi Bach ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Spongistatin 1 ◽  
Altohyrtin A

Recent Advances in the Total Synthesis of Polyketide Natural Products as Promising Anticancer Agents

2009 ◽  
Vol 62 (7) ◽  
pp. 624 ◽  
Author(s):  
Ian Paterson ◽  
Alison D. Findlay
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Therapeutic Agents ◽  
Natural Abundance ◽  
Spongistatin 1 ◽  
Lead Compounds ◽  
Altohyrtin A ◽  
Synthetic Routes

A growing number of complex polyketides, isolated from a variety of marine and terrestrial sources, present novel scaffolds for the development of cancer therapeutic agents. However, the low natural abundance of such lead compounds often precludes full biological evaluation, which demands the development of efficient synthetic routes to afford a sustainable supply. In this account, we provide an overview of the total synthesis of several representative anticancer polyketides – dolastatin 19, spirangien A, reidispongiolide A, and spongistatin 1/altohyrtin A – based on versatile aldol methodology developed in our group.

Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1

2001 ◽  
Vol 113 (21) ◽  
pp. 4179-4184 ◽  
Author(s):  
Ian Paterson ◽  
David Y.-K. Chen ◽  
Mark J. Coster ◽  
Jose L. Aceña ◽  
Jordi Bach ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Spongistatin 1 ◽  
Altohyrtin A

ChemInform Abstract: Total Synthesis of Altohyrtin A (Spongistatin 1). Part 1.

ChemInform ◽  
2010 ◽  
Vol 29 (18) ◽  
pp. no-no
Author(s):  
J. GUO ◽  
K. J. DUFFY ◽  
K. L. STEVENS ◽  
P. I. DALKO ◽  
R. M. ROTH ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Spongistatin 1 ◽  
Altohyrtin A

ChemInform Abstract: Total Synthesis of Altohyrtin A (Spongistatin 1). Part 2.

ChemInform ◽  
2010 ◽  
Vol 29 (18) ◽  
pp. no-no
Author(s):  
M. M. HAYWARD ◽  
R. M. ROTH ◽  
K. J. DUFFY ◽  
P. I. DALKO ◽  
K. L. STEVENS ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Spongistatin 1 ◽  
Altohyrtin A

Total Synthesis of Spongistatin 1 (Altohyrtin A): A Tale of Ten Aldols

ChemInform ◽  
2005 ◽  
Vol 36 (38) ◽  
Author(s):  
Ian Paterson ◽  
Mark J. Coster
Keyword(s):  
Total Synthesis ◽  
Spongistatin 1 ◽  
Altohyrtin A

Total Synthesis of Altohyrtin A (Spongistatin 1): Part 1

1998 ◽  
Vol 37 (1-2) ◽  
pp. 187-190 ◽  
Author(s):  
Jiasheng Guo ◽  
Kevin J. Duffy ◽  
Kirk L. Stevens ◽  
Peter I. Dalko ◽  
Rebecca M. Roth ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Spongistatin 1 ◽  
Altohyrtin A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment

2005 ◽  
Vol 3 (13) ◽  
pp. 2399 ◽  
Author(s):  
Ian Paterson ◽  
Mark J. Coster ◽  
David Y.-K. Chen ◽  
Renata M. Oballa ◽  
Debra J. Wallace ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Spongistatin 1 ◽  
Altohyrtin A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment

2005 ◽  
Vol 3 (13) ◽  
pp. 2420 ◽  
Author(s):  
Ian Paterson ◽  
Mark J. Coster ◽  
David Y.-K. Chen ◽  
José L. Aceña ◽  
Jordi Bach ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Southern Hemisphere ◽  
Spongistatin 1 ◽  
Altohyrtin A
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