New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones

MedChemComm ◽  
2011 ◽  
Vol 2 (2) ◽  
pp. 132-139 ◽  
Author(s):  
Andrés A. Trabanco ◽  
Guillaume Duvey ◽  
José María Cid ◽  
Gregor J. Macdonald ◽  
Philippe Cluzeau ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
High Throughput ◽  
High Throughput Screening ◽  
Metabotropic Glutamate Receptor ◽  
Allosteric Modulators ◽  
Metabotropic Glutamate ◽  
Positive Allosteric Modulators

N-propyl-5-substituted isoquinolones were identified as mGluR2 PAMs via high-throughput screening (HTS). Initial SAR exploration led to the identification of compound 20.

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

ChemMedChem ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. 2685-2698 ◽  
Author(s):  
Xavier Rovira ◽  
Youssef Harrak ◽  
Ana Trapero ◽  
Patricia González-Bulnes ◽  
Fanny Malhaire ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Allosteric Modulators ◽  
Active Conformation ◽  
Metabotropic Glutamate ◽  
Cyclohexane Carboxylate ◽  
Positive Allosteric Modulators

scholarly journals Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators

2016 ◽  
Vol 7 (12) ◽  
pp. 1082-1086 ◽  
Author(s):  
Matthew D. Hill ◽  
Haiquan Fang ◽  
Jeffrey M. Brown ◽  
Thaddeus Molski ◽  
Amy Easton ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Allosteric Modulators ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate ◽  
Positive Allosteric Modulators

4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators

2012 ◽  
Vol 22 (9) ◽  
pp. 3235-3239 ◽  
Author(s):  
Hermogenes N. Jimenez ◽  
Kevin G. Liu ◽  
Sang-Phyo Hong ◽  
Michael S. Reitman ◽  
Michelle A. Uberti ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Allosteric Modulators ◽  
Metabotropic Glutamate ◽  
Positive Allosteric Modulators

Progress in the Developement of Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

2011 ◽  
Vol 18 (1) ◽  
pp. 47-68 ◽  
Author(s):  
A. A. Trabanco ◽  
J. M. Cid ◽  
H. Lavreysen ◽  
G. J. Macdonald ◽  
G. Tresadern
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Allosteric Modulators ◽  
Metabotropic Glutamate ◽  
Positive Allosteric Modulators
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