Rapid analysis of abused drugs using nanostructured silicon surface assisted laser desorption/ionization mass spectrometry

The Analyst ◽  
2012 ◽  
Vol 137 (3) ◽  
pp. 654-661 ◽  
Author(s):  
Yu-Che Cheng ◽  
Kun-Han Chen ◽  
Juo-Shin Wang ◽  
Wen-Liu Hsu ◽  
Chih-Cheng Chien ◽  
...  
2021 ◽  
pp. 146906672110060
Author(s):  
Alexander A Grechnikov ◽  
Alexey S Borodkov ◽  
Yaroslav O Simanovsky ◽  
Sergey M Nikiforov

The approach to quantitative analysis by silicon Surface Assisted Laser Desorption Ionization Mass Spectrometry (Si-SALDI) is proposed. The approach is based on the new method for forming an active surface layer on a silicon substrate by exposing to laser radiation directly in the ion source of a mass spectrometer. The method can be used repeatedly on the same substrate, providing high reproducibility of its surface ionization properties and high ionization efficiency of organic compounds. Within the proposed approach, the methods of improvement of signal reproducibility are also considered, including continuous monitoring of the silicon surface ionization properties using a Knudsen effusion cell; scanning the surface of a silicon substrate with a laser beam; selecting the optimal value of laser fluence and using a reproducible sample introduction technique. It is demonstrated that this approach can be successfully applied to quantify clinically relevant concentrations of pharmaceutical drugs in extracts of blood.


The Analyst ◽  
2020 ◽  
Vol 145 (16) ◽  
pp. 5664-5669
Author(s):  
Kailong Luo ◽  
Baichuan Yang ◽  
Wenjing Guo ◽  
Qianqian Sun ◽  
Ouyang Dan ◽  
...  

Polydopamine nanospheres was designed to serve as a substrate for surface-enhanced desorption/ionization mass spectrometry, which showed superior LDI performance in the analysis of a variety of environmental pollutants.


2012 ◽  
Vol 75 (7) ◽  
pp. 1973-1990 ◽  
Author(s):  
Mathieu Dupré ◽  
Yannick Coffinier ◽  
Rabah Boukherroub ◽  
Sonia Cantel ◽  
Jean Martinez ◽  
...  

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