Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans
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A chiral cooperative catalysis of NHC and Brønsted acid for a formal [4+2] reaction of unprotected isatins and enals was developed for the direct synthesis of unprotected spiro[indoline-3,2′-pyran]-2,6′(3′H)-diones in good to excellent yields (up to 95%) with high enantioselectivities (up to >93% ee).
2014 ◽
Vol 356
(16)
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pp. 3451-3455
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2019 ◽
Vol 58
(8)
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pp. 2495-2499
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2016 ◽
Vol 138
(43)
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pp. 14354-14361
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