An organic-base catalyzed asymmetric 1,4-addition of tritylthiol to in situ generated aza-o-quinone methides at the H2O/DCM interface

Xianghui Liu; Kai Wang; Wengang Guo; Yan Liu; Can Li

doi:10.1039/c8cc09382b

An organic-base catalyzed asymmetric 1,4-addition of tritylthiol to in situ generated aza-o-quinone methides at the H2O/DCM interface

Chemical Communications ◽

10.1039/c8cc09382b ◽

2019 ◽

Vol 55 (18) ◽

pp. 2668-2671 ◽

Cited By ~ 4

Author(s):

Xianghui Liu ◽

Kai Wang ◽

Wengang Guo ◽

Yan Liu ◽

Can Li

Keyword(s):

Michael Addition ◽

Organic Base ◽

Quinone Methides

Highly enantioselective organocatalytic Michael addition of tritylthiol to N-o-QM intermediates generated in situ at the H2O/DCM interface is presented.

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Correction: An organic-base catalyzed asymmetric 1,4-addition of tritylthiol to in situ generated aza-o-quinone methides at the H2O/DCM interface

Chemical Communications ◽

10.1039/c9cc90341k ◽

2019 ◽

Vol 55 (64) ◽

pp. 9567-9567

Author(s):

Xianghui Liu ◽

Kai Wang ◽

Wengang Guo ◽

Yan Liu ◽

Can Li

Keyword(s):

Organic Base ◽

Quinone Methides

Correction for ‘An organic-base catalyzed asymmetric 1,4-addition of tritylthiol to in situ generated aza-o-quinone methides at the H2O/DCM interface’ by Xianghui Liu et al., Chem. Commun., 2019, 55, 2668–2671.

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Metal-Free One-Pot Synthesis of 3-Phosphinoylbenzofurans via Phospha-Michael Addition/Cyclization of H-Phosphine Oxides and in Situ Generated ortho-Quinone Methides

Organic Letters ◽

10.1021/acs.orglett.7b03863 ◽

2018 ◽

Vol 20 (2) ◽

pp. 477-480 ◽

Cited By ~ 34

Author(s):

Ji-Yuan Du ◽

Yan-Hua Ma ◽

Rui-Qing Yuan ◽

Nana Xin ◽

Shao-Zhen Nie ◽

...

Keyword(s):

Michael Addition ◽

Phosphine Oxides ◽

Quinone Methides ◽

One Pot ◽

Metal Free ◽

One Pot Synthesis

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Relay Cu(I)/Brønsted Base Catalysis for Phospha ‐Michael Addition/5‐ exo ‐ dig Cyclization/Isomerization of in situ Formed aza ‐Alkynyl o‐ quinone methides with P(O)−H compounds to C3‐Phosphorylated Indoles

Advanced Synthesis & Catalysis ◽

10.1002/adsc.202100275 ◽

2021 ◽

Author(s):

Long Chen ◽

Xiao‐Yan Liu ◽

Jing Zhang ◽

Li Duan ◽

Zhong Wen ◽

...

Keyword(s):

Michael Addition ◽

Base Catalysis ◽

Quinone Methides ◽

Brønsted Base

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Squaramide-Catalyzed Enantioselective Michael Addition of Pyrazol-3- ones to ortho-Quinone Methides

Letters in Organic Chemistry ◽

10.2174/1876402911666190806105543 ◽

2020 ◽

Vol 17 (11) ◽

pp. 837-844

Author(s):

Laura Carceller-Ferrer ◽

Gonzalo Blay ◽

José R. Pedro ◽

Carlos Vila

Keyword(s):

Michael Addition ◽

Enantiomeric Excess ◽

Quinone Methides

A bifunctional squaramide catalyzed the enantioselective Michael addition of pyrazol-3- ones to ortho-quinone methides, generated in situ from 2-(1-tosylalkyl)phenols is presented. The corresponding chiral pyrazolones are obtained with good to excellent yields (27-98%) and enantiomeric excess (14-99% ee).

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